货号 | 产品名 | 中文名称 | 产品描述 |
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SJ-BP0339 | TAT TFA |
TAT TFA (YGRKKRRQRRR) 源自人免疫缺陷病毒 (HIV-1) 的转录反式激活因子 (TAT),是一种穿透细胞的肽。TAT 可以增加异源蛋白质的产量和溶解度。 |
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SJ-MX3596 | Lersivirine | Lersivirine is a non-nucleoside, next generation reverse transcriptase inhibitor (IC50 = 118 nM for the wild-type HIV-1 enzyme). It inhibits a panel of 14 single-point mutant HIV-1 reverse transcriptases with mean IC50 values within 10-fold of the wild-type enzyme. Lersivirine inhibits HIV-1 virus replication in MT-2 cells with EC50 values of 5.04, 13.1, and 34.9 nM at multiplicities of infection (MOIs) of 0.005, 0.05, and 0.5, respectively, and displays synergistic or additive effects when used in combination with a variety of antiretroviral agents. | |
SJ-MA0069D | Tenofovir hydrate | 替诺福韦水合物 |
Tenofovir hydrate (GS 1278 hydrate) 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂,可用于 HIV和慢性乙型肝炎 (Hepatitis B; HBV) 的研究。 |
SJ-BP0213 | DAPTA |
DAPTA (RAP-101; DAPTA; DAPTA) 是一种合成肽,为 CCR5 抑制剂,同时具有抗 HIV 的活性。 |
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SJ-MX2576 | Dapivirine | 达匹维林 | Dapivirine (TMC120) 是二芳基嘧啶 (DAPY) 的原型,是具有口服活性的非核苷类逆转录酶抑制剂 (NRTI)。Dapivirine (TMC120) 可直接与 HIV 的逆转录酶结合。Dapivirine (TMC120)调节自噬并诱导 Akt、Bad 和 SAPK/JNK 的激活。 |
SJ-MA0076A | Raltegravir potassium | 雷特格韦钾盐 | Raltegravir potassium (formerly also known as MK-0518 potassium; trade name: Isentress) is a novel, potent integrase (IN) inhibitor for WT and S217Q PFV IN with IC50 of 90 nM and 40 nM in cell-free assays, respectively. Raltegravir is an antiretroviral drug used to treat HIV infection. Raltegravir binds to and inhibits integrase, an HIV enzyme that inserts viral genetic material into the genetic material of the infected human cell. Inhibition of integrase prevents insertion of HIV DNA into the human DNA genome, thus blocking HIV replication. |
SJ-MA0069E | Tenofovir Disoproxil | 替诺福韦酯 |
Tenofovir Disoproxil (Bis(POC)-PMPA) 是核苷酸逆转录酶抑制剂 (nucleotide reverse transcriptase inhibitor),有潜力用于艾滋病和慢性乙型肝炎的研究。 |
SJ-MA0362 | Temsavir | Temsavir (formerly known as BMS-626529) is a novel, potent attachment inhibitor that targets HIV-1 gp120 and prevents its binding to CD4+ T cells. Temsavir is also the phosphonooxymethyl prodrug of BMS-626529 that targets HIV-1 gp120 and prevents its binding to CD4(+) T cells. BMS-626529 had half-maximal effective concentration (EC(50)) values of6 log(10), with half-maximal effective concentration values in the low pM range against the most susceptible viruses. | |
SJ-MA0406 | RN-18 | RN-18是HIV-1病毒感染因子 ( HIV-1 Vif) 的拮抗剂,在非允许细胞 H9 中的 IC50 为6 µM。 | |
SJ-MA0433 | (S)-Tenofovir | (S)-替诺福韦 | (S)-Tenofovir ((S)-GS 1278) 是 Tenofovir 的低活性 S 型异构体。Tenofovir 是一种核苷酸逆转录酶 (nucleotide reverse transcriptase) 抑制剂,可用于 HIV 和慢性乙型肝炎的研究 (Hepatitis B; HBV)。 |
SJ-MA0434 | beta-L-D4A | beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. | |
SJ-MA0169 | Inosine pranobex | Inosine pranobex (Imunovir; Delimmun; Groprinosin), a combinatinon of inosine, acetamidobenzoic acid, and dimethylaminoisopropanol, is a novel, potent, broad-spectrum antiviral agent potentially useful for HIV/AIDs infection. Inosine pranobex is also an immunopotentiator/immunostimulant, and has no direct effect on viral cells. | |
SJ-MA0280A | Erythromycin Ethylsuccinate | 琥乙红霉素 | Erythromycin Ethylsuccinate是一种抗生素,有用于多种细菌感染的潜能,具有与青霉素类似或稍宽于青霉素的抗菌谱。 Erythromycin Ethylsuccinate 具有抗 HIV-1 病毒的活性。 |
SJ-MA0352 | Salicylanilide | Salicylanilide (also known as WR10019; 2-Hydroxybenzanilide) exhibits a wide range of biological activities including antiviral potency, antibacterial (including antimycobacterial) and antifungal activities. Some salicylanilides and salicylamides could inhibit HIV virus by targeting of HIV-1 integrase or reverse transcriptase. Hepatitis C virus could be potentially afflicted by salicylanilides on the level of two enzymes – NS3 protease and NS5B RNA polymerase. | |
SJ-MB0096 | Ditiocarb sodium | 二乙基二硫代氨基甲酸钠 | Ditiocarb sodium (Sodium diethyldithiocarbamate) 是一种铜试剂,与 Cu2+ 溶液反应,生成络合物,提高了铜置换沉淀速率。Sodium diethyldithiocarbamate 可降低 HIV 感染。 |
SJ-MH0053 | Megestrol acetate | 醋酸甲地孕酮 | Megestrol acetate (formerly BDH1298, SC10363; BDH-1298; SC-10363; Megace; Ovaban; Pallace; Maygace; Megestil; Niagestin) is a synthetic progestogen derivative that has been approved for use in the treatment of breast cancer and loss of appetite. Megestrol Acetate shows potent anti-proliferative activity in vitro against various cancer cell lines such as HepG2 cells with an IC50 value of 260 μM. |
SJ-MA0063A | Nelfinavir | Nelfinavir is an antiretroviral drug used in the treatment of the human immunodeficiency virus (HIV). | |
SJ-MA0173A | Darunavir | 达芦那韦 | Darunavir is a potent human immunodeficiency virus type 1 (HIV-1) protease inhibitor with an IC50 value of 0.003 μM (HIV-1LAI). Moreover, Darunavir shows potent activity against multi-protease inhibitor-resistant HIV in vitro. |
SJ-MA0443 | Zalcitabine | Zalcitabine is a nucleoside analog reverse transcriptase inhibitor (NRTI). | |
SJ-MA0478 | Saquinavir | 沙奎那韦 | Saquinavir is an HIV Protease Inhibitor used in antiretroviral therapy. Saquinavir inhibits both HIV-1 and HIV-2 proteases. Studies have also looked at Saquinavir as a possible anti-cancer agent. |