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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MA0103 | Nitazoxanide | 硝唑克酰胺 |
Nitazoxanide (NTZ; NSC 697855) 是一种广谱驱虫剂 (anthelmintic)，对感染动物和人类的各种蠕虫、原生动物和肠道细菌都具有作用活性。 Nitazoxanide 在无菌培养中抑制 Giardia lamblia 滋养体增殖，IC50 为 2.4 μM。Nitazoxanide 可用于寄生虫性 (parasitic) 胃肠炎的研究。Nitazoxanide还具有抗病毒特性。 Nitazoxanide 在小鼠模型中显示出抗日本脑炎病毒 (JEV) 活性。 |
| SJ-MN0069 | Dihydroartemisinin (DHA) | 双氢青蒿素 |
Dihydroartemisinin (DHA)从传统中药Artemisia annua分离而来的，是一种有效的抗疟疾 (anti-malaria) 药物。Dihydroartemisinin 可通过抑制 NF-κB 激活来诱导自噬（autophagy）和凋亡（apoptosis）。 |
| SJ-MA0102 | Niclosamide | 氯硝柳胺 |
Niclosamide (BAY2353) 是STAT3信号通路抑制剂。Niclosamide 能有效抑制STAT3的激活和转录功能，并诱导具有组成型活性STAT3的癌细胞系的细胞生长抑制、凋亡和细胞周期阻滞。还可逆地抑制mTORC1信号传导并刺激体外自噬(autophagy)；在急性髓系白血病（AML）干细胞中具有抗肿瘤作用。在体外药物筛选研究中，Niclosamide可能通过干扰宿主调节通路来抑制SARS-CoV 。 |
| SJ-MA0048A | Chloroquine | 氯喹 | Chloroquine 是一种广泛用于疟疾和类风湿性关节炎的抗炎试剂。Chloroquine 是自噬 (autophagy) 和 Toll 样受体 (TLRs) 的抑制剂。Chloroquine 有效抑制 SARS-CoV-2 (COVID-19) 感染 (EC50=1.13 μM)。 |
| SJ-MX2773 | Decoquinate | 癸氧喹酯 | Decoquinate is a nonantibiotic coccidiostat. |
| SJ-MX3268 | Purvalanol B | Purvalanol B (formerly known as NG-95) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, inhibiting Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively. | |
| SJ-MX2678 | Obatoclax | 奥巴克拉 | Obatoclax (GX15-070) 是 BH3 模拟物，是泛 BCL-2 家族蛋白抑制剂，对 BCL-2 的 Ki 值为 220 nM。Obatoclax 诱导自噬 (autophagy) 依赖性细胞死亡，并靶向细胞周期蛋白 D1 进行蛋白酶体降解。Obatoclax 具有抗癌和广谱抗寄生虫 (antiparasitic) 活性。 |
| SJ-MX2513 | Atovaquone | 阿托伐醌 | Atovaquone (Atavaquone) is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa. It inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95, 0.94, and 510 nM, respectively) and depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes (EC50 = 260 nM). Atovaquone also inhibits transport mediated by human breast cancer resistance protein (BCRP) and P-glycoprotein in membrane vesicles (IC50s = 0.23 and 6.8 μM, respectively. |
| SJ-MN0648 | Leonuride | 益母草苷 | Ajugol 是一种环烯醚糖苷，能从 Sideritis germanicopolitana 分离得到。Ajugol 具有抗原生动物活性，对 Trypanosoma b. rhodesiense 锥虫的 IC50 为 31.8 μg/mL。 |
| SJ-MX4034 | SQ109 | SQ109是一种有效的锥虫（trypomastigote form of the parasite）抑制剂，对LLC-MK2培养衍生的锥虫（LLC-MK2 culture-derived trypomastigotes）的IC50为50±8 nM，在结核分枝杆菌中靶向分枝杆菌膜蛋白3（mycobacterial membrane protein large 3，MmpL3）。 | |
| SJ-MA0319 | Paromomycin sulfate | 硫酸巴龙霉素 | Paromomycin Sulfate is an aminoglycoside antibiotic that inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death. |
| SJ-MX2492 | Pyriproxyfen | 吡丙醚 | Pyriproxyfen is an insect growth regulator; a juvenile hormone analogue and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae. |
| SJ-MX2582 | Diclazuril | 地克珠利 | Diclazuril (R-64433)，苯乙腈衍生物，是一种有效的，具有口服活性的抗球虫剂 (anticoccidial agent)。Diclazuril (R-64433) 可用于某些传染病和寄生虫病的相关研究，如球虫病、急性弓形体病、马源虫性脑脊髓炎 (EPM) 等。 |
| SJ-MX2583 | Diethylcarbamazine citrate | 枸橼酸乙胺嗪 | Diethylcarbamazine citrate is an inhibitor of arachidonic acid metabolism in filarial microfilaria; is highly specific for several parasites and does not contain any toxic metallic elements. |
| SJ-MX2638 | Levamisole hydrochloride | 盐酸左旋咪唑 | Levamisole hydrochloride is a highly active anthelmintic agent. |
| SJ-MX2663 | Albendazole sulfoxide | Albendazole sulfoxide (Ricobendazole) 是Albendazole 的主要代谢物，具有抗寄生虫活性 (e.g. Echinococcus multilocularis)。 | |
| SJ-MX2675 | Nimorazole | 尼莫拉唑 | Nimorazole,a nitroimidazole anti-infective, is a hypoxic radiosensitizer potentially useful in the treatment of patients with head and neck squamous cell carcinoma (HNSCC). Nimorazole significantly improves the effect of radiotherapeutic management of supraglottic and pharynx tumors and can be given without major side-effects. Nimorazole is the only such chemical reagent that has shown a significant effect in a randomized controlled trial in head and neck cancer. |
| SJ-MX2695 | Praziquantel | 吡喹酮 | Praziquantel 是一种外消旋混合物，由 (R)-Praziquantel 和 (S)-Praziquantel 组成。Praziquantel 是安全的，可用于血吸虫病的研究。 |
| SJ-MX2703 | Pyrantel pamoate | 双羟萘酸噻嘧啶 | Pyrantel pamoate, the pamoate salt of pyrantel, is a potent antinematodal and anthelmintic agent with a broad spectrum of activities. |
| SJ-MX2761 | Cloxiquine | 5-氯-8-羟基喹啉 | Cloxiquine (5-Chloro-8-quinolinol) 具有抗菌，抗真菌和抗阿米巴虫的功效。Cloxiquine 可用于结核病和皮肤病的研究。Cloxiquine 还可以通过激活 PPARγ抑制黑素瘤细胞的生长和转移。 |
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