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Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Anti-infection

Antibiotic

Arenavirus

Bacterial

CMV

Enterovirus

Filovirus

Fungal

HBV

HCV

HCV Protease

HIV

HIV Integrase

HIV Protease

HSV

Influenza Virus

Orthopoxvirus

Parasite

TMV

Reverse Transcriptase

RSV

SARS-CoV

Virus Protease

RABV

HPV

DENV

RABV
Apoptosis

Apoptosis

Bcl-2 Family

Caspase

Caspase抑制剂 Caspase激活剂 Caspase诱导剂 Caspase调节剂

c-Myc

DAPK

Ferroptosis

Ferroptosis激活剂 Ferroptosis抑制剂 Ferroptosis诱导剂

FKBP

IAP Family

Survivin

MDM-2/p53

PKD

Necroptosis

Pyroptosis

Pyroptosis抑制剂 Pyroptosis激活剂 Pyroptosis诱导剂

RIP kinase

RIP kinase 抑制剂

Thymidylate Synthase

TNF Receptor

TNF Receptor抑制剂 TNF Receptor激活剂 TNF Receptor激动剂 TNF Receptor调节剂 TNF Receptor拮抗剂 TNF Receptor诱导剂

TRADD

Cuproptosis

DAPK
Autophagy

Autophagy

FKBP

LRRK2

Mitophagy

Mitophagy抑制剂 Mitophagy激活剂 Mitophagy调节剂 Mitophagy诱导剂

OGA

ULK

ULK抑制剂 ULK激活剂

Beclin1

Atg4
Cell Cycle/DNA Damage

Antifolate

APC

ATM/ATR

Aurora Kinase

Aurora Kinase抑制剂 Aurora Kinase调节剂

BMI-1

Casein Kinase

CDK

Checkpoint Kinase (Chk)

CRISPR/Cas9

CRISPR/Cas9激动剂 CRISPR/Cas9激活剂 CRISPR/Cas9诱导剂 CRISPR/Cas9抑制剂

Deubiquitinase

DNA Alkylator/Crosslinker

DNA/RNA Synthesis

DNA/RNA Synthesis抑制剂 DNA/RNA Synthesis激活剂 DNA/RNA Synthesis激动剂 DNA/RNA Synthesis化学品 DNA/RNA Synthesis拮抗剂 DNA/RNA Synthesis调节剂

DNA-PK

Early 2 Factor (E2F)

Eukaryotic Initiation Factor (eIF)

GAK

G-quadruplex

Haspin Kinase

HDAC

HDAC抑制剂 HDAC降解剂 HDAC拮抗剂 HDAC激活剂 HDAC调节剂

HSP

HSP抑制剂 HSP拮抗剂 HSP激活剂 HSP激动剂 HSP降解剂 HSP诱导剂

IRE1

Kinesin

LIM Kinase (LIMK)

Microtubule/Tubulin

Mps1

DNA Stain

Nucleoside Antimetabolite/Analog

p97

PAK

PAK抑制剂 PAK激活剂

PARP

PARP抑制剂 PARP激活剂 PARP诱导剂 PARP降解剂

PERK

PFKFB3

Polo-like Kinase (PLK)

PPAR

RAD51

Cyclin G-associated Kinase (GAK)

ROCK

ATF6

Haspin Kinase

Sirtuin

Sirtuin抑制剂 Sirtuin激活剂 Sirtuin调节剂 Sirtuin激动剂

SRPK

PDI

Telomerase

TOPK

Topoisomerase

Wee1

YB-1

poly (ADP ribose) glycohydrolase (PARG)

OGG1
Cytoskeletal Signaling

Arp2/3 Complex

Dynamin

Gap Junction Protein

Integrin

Integrin激动剂 Integrin抑制剂 Integrin调节剂 Integrin拮抗剂

Kinesin

Microtubule/Tubulin

Mps1

Myosin

Myosin抑制剂 Myosin激活剂 Myosin调节剂

PAK

PAK抑制剂 PAK激活剂

ROCK
Epigenetics

AMPK

AMPK抑制剂 AMPK激活剂 AMPK诱导剂

Aurora Kinase

Aurora Kinase抑制剂 Aurora Kinase调节剂

DNA Methyltransferase

Epigenetic Reader Domain

Epigenetic Reader Domain抑制剂 Epigenetic Reader Domain激动剂 Epigenetic Reader Domain降解剂 Epigenetic Reader Domain调节剂 Epigenetic Reader Domain化学品

HDAC

HDAC抑制剂 HDAC降解剂 HDAC拮抗剂 HDAC激活剂 HDAC调节剂

Histone Acetyltransferase

Histone Acetyltransferase抑制剂 Histone Acetyltransferase降解剂 Histone Acetyltransferase激活剂 Histone Acetyltransferase调节剂

Histone Demethylase

Histone Demethylase抑制剂 Histone Demethylase拮抗剂 Histone Demethylase激活剂

Histone Methyltransferase

Histone Methyltransferase抑制剂 Histone Methyltransferase降解剂 Histone Methyltransferase拮抗剂 Histone Methyltransferase激活剂 Histone Methyltransferase调节剂 Histone Methyltransferase化学品

MicroRNA

PARP

PARP抑制剂 PARP激活剂 PARP诱导剂 PARP降解剂

PKC

PKC激活剂 PKC抑制剂 PKC拮抗剂 PKC调节剂 PKC激动剂

Protein Arginine Deiminase

Methionine Adenosyltransferase (MAT)

Sirtuin

Sirtuin抑制剂 Sirtuin激活剂 Sirtuin调节剂 Sirtuin激动剂

JAK

JAK抑制剂 JAK激活剂

TET Protein
GPCR/G Protein

5-HT Receptor

5-HT Receptor拮抗剂 5-HT Receptor激动剂 5-HT Receptor抑制剂 5-HT Receptor调节剂 5-HT Receptor激活剂 5-HT Receptor诱导剂

Adenosine Receptor

Adenosine Receptor拮抗剂 Adenosine Receptor激动剂 Adenosine Receptor抑制剂 Adenosine Receptor调节剂 Adenosine Receptor激活剂

Adenylate Cyclase (AC)

Adrenergic Receptor

Adrenergic Receptor激动剂 Adrenergic Receptor拮抗剂 Adrenergic Receptor抑制剂 Adrenergic Receptor激活剂 Adrenergic Receptor调节剂

Angiotensin Receptor

Bombesin Receptor

Bradykinin Receptor

Cannabinoid Receptor

CaSR

CCR

CGRP Receptor

Cholecystokinin Receptor

CRFR

CXCR

TSH Receptor

Neuropeptide Y Receptor

Dopamine Receptor

EBI2/GPR183

Endothelin Receptor

Formyl peptide receptor (FPR)

GHSR

Glucagon Receptor

GNRH Receptor

GPR109A

GPR119

GPR139

GPR27

GPR55

GPR84

Guanylate Cyclase

Histamine Receptor

Imidazoline Receptor

Leukotriene Receptor

LPL Receptor

mAChR

MCHR1 (GPR24)

Melanocortin Receptor

Melatonin Receptor

mGluR

Motilin Receptor

Neurokinin Receptor

Neurotensin Receptor

Opioid Receptor

Orexin Receptor (OX Receptor)

Oxytocin Receptor

P2Y Receptor

PKG

Prostaglandin Receptor

Protease-Activated Receptor (PAR)

Apelin Receptor (APJ)

Ras

GPR88

Free Fatty Acid Receptor

RGS

GPR4

Secretin Receptor

Mas-related G-protein-coupled Receptor (MRGPR)

GPR35

GPR52

MCHR1 (GPR24)

Leukotriene Receptor

GLP Receptor

Somatostatin Receptor

Arrestin

Platelet-activating Factor Receptor (PAFR)

Mas-related G-protein-coupled Receptor (MRGPR)

Kisspeptin Receptor

G Protein-coupled Receptor Kinase (GRK)

G protein-coupled Bile Acid Receptor 1

Succinate Receptor 1

TSH Receptor

Protease Activated Receptor (PAR)

Urotensin Receptor

Vasopressin Receptor

Motilin Receptor

TF
Immunology/Inflammation

Arginase

Aryl Hydrocarbon Receptor (AhR)

CCR

Complement System

COX

CXCR

Cyclic GMP-AMP Synthase (cGAS)

TIM-3

TIGIT

CTLA-4

FKBP

FLAP

Galectin

IFNAR

Interleukin Related

IRAK

MIF

MyD88

NO Synthase

NOD-like Receptor (NLR)

PD-1/PD-L1

PGE synthase

CX3CR1

Pyroptosis

Pyroptosis抑制剂 Pyroptosis激活剂 Pyroptosis诱导剂

Nuclear Factor of activated T Cells (NFAT)

Reactive Oxygen Species

AP-1

Salt-inducible Kinase (SIK)

SOD

SPHK

STING

STING 抑制剂 STING 激动剂

Thrombopoietin Receptor

Toll-like Receptor (TLR)

AP-1

PSMA

Glucocorticoid Receptor (GR)

FAP

Histamine Receptor

Macrophage migration inhibitory factor (MIF)

LAG-3

Mucin

Tim3

Mesothelin

Nectin-4

P-selectin

TROP2

CD79B

DPEP3

BCMA

MUC16

BAFF

CD markers

FcRn

CSF2

IgE

Glycoprotein VI
JAK/STAT Signaling

EGFR

HER2

HER3

HER4

JAK

JAK抑制剂 JAK激活剂

Pim

STAT

MUC16
MAPK Signaling Pathway

ERK

JNK

KLF

MAP3K

MAP4K

MEK

Mixed Lineage Kinase

MNK

p38 MAPK

Raf

Ribosomal S6 Kinase (RSK)

MAPKAPK2 (MK2)

Macrophage migration inhibitory factor (MIF)

CD79B

BCMA
Membrane Transporter/Ion Channel

Amino acid transporter

Aquaporin (AQP)

ATP synthase

ATPase

BCRP

Calcium Channel

CFTR

Chloride Channel

CRAC Channel

CRM1

iGluR

URAT1

Piezo Channel

EAAT

GABA Receptor

GLUT

GlyT

HCN Channel

iGluR

Mechanosensitive channels (MSCs)

Monoamine Transporter (MAT)

Monocarboxylate Transporter (MCT)

Na+/Ca2+ Exchanger

Na+/HCO3- Cotransporter

nAChR

NKCC

P2X Receptor

P-glycoprotein

Potassium Channel

Proton Pump

EAAT

HCN Channel

SGLT

Sodium Channel

Apical Sodium-Dependent Bile Acid Transporter

TRP Channel

Na+/K+ ATPase

Organic Anion Transporting Polypeptide (OATP)

VDAC

Na+/H+ Exchanger (NHE)

NaPi2b

NaPi2b
Metabolic Enzyme/Protease

Glucose Metabolism

Aldose Reductase Carbonic Anhydrase Enolase FBPase Glucokinase Glucosidase Glutathione Peroxidase Glyoxalase (GLO) Hexokinase HIF/HIF Prolyl-Hydroxylase Lactate Dehydrogenase (LDH) Mineralocorticoid Receptor (MR) Phosphoglycerate Dehydrogenase (PHGDH) PEPCK Pyruvate Kinase SGK Glucose-6-phosphate dehydrogenase (G6PD) NAMPT Mitochondrial Metabolism NADPH Oxidase PGC-1α Phosphatase Reactive Oxygen Species Amylases

Lipid Metabolism

11β-HSD 15-PGDH 17β-HSD 5α-reductase Acetyl-CoA carboxylase Acyltransferase Adiponectin Receptor Aldehyde Dehydrogenase (ALDH) ATGL ATP Citrate Lyase Ceramidase CETP Cytochrome P450 DGK Epoxide Hydrolase FAAH FABP Fat Mass and Obesity-associated Protein (FTO) Fatty Acid Synthase (FASN) Farnesoid X receptor (FXR) HMG-CoA Reductase (HMGCR) Isocitrate Dehydrogenase (IDH) LDLR Liposome Liver X Receptor (LXR) MAGL Microsomal Triglyceride Transfer Protein (MTP) PDHK Stearoyl-CoA Desaturase (SCD) ROR REV-ERB RAR/RXR Phospholipase Lipoxygenase Mitochondrial Metabolism NADPH Oxidase PGC-1α Phosphatase Reactive Oxygen Species

Amino Acid/Protein Metabolism

Acetolactate Synthase (ALS) Adenosine Deaminase Adenosine Kinase Carboxypeptidase GSNOR MALT1 Methionine Adenosyltransferase (MAT) Furin HCV Protease HIV Protease HPPD Aminopeptidase Angiotensin-converting Enzyme (ACE) Arginase Cathepsin COMT Dipeptidyl Peptidase Dopamine β-hydroxylase Elastase Factor Xa Farnesyl Transferase (FTase) Glutaminase Gutathione S-transferase HSP Indoleamine 2,3-Dioxygenase (IDO) MMP NEDD8-activating Enzyme Neprilysin PAI-1 PDI Procollagen C Proteinase Prolyl Endopeptidase (PREP) Renin Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase Proteasome Ser/Thr Protease Methylenetetrahydrofolate Dehydrogenase (MTHFD) Mitochondrial Metabolism NADPH Oxidase Phosphatase Reactive Oxygen Species

Nucleic Acid Metabolism

Aminoacyl-tRNA Synthetase Cryptochrome Dihydrofolate reductase (DHFR) Dihydroorotate Dehydrogenase (DHODH) HIV Integrase Phosphodiesterase (PDE) Methylenetetrahydrofolate Dehydrogenase (MTHFD) NAMPT OGG1

Drug Metabolite

Vitamin

Vitamin A Vitamin B Vitamin C Vitamin D/VDR Vitamin E1 Vitamin K

Endogenous Metabolite

Factor VIII

Factor VIII
Neuronal Signaling

5-HT Receptor

5-HT Receptor拮抗剂 5-HT Receptor激动剂 5-HT Receptor抑制剂 5-HT Receptor调节剂 5-HT Receptor激活剂 5-HT Receptor诱导剂

Cholinesterase (ChE)

Adenosine Kinase

Adrenergic Receptor

Adrenergic Receptor激动剂 Adrenergic Receptor拮抗剂 Adrenergic Receptor抑制剂 Adrenergic Receptor激活剂 Adrenergic Receptor调节剂

Calcium Channel

CaMK

Cannabinoid Receptor

CGRP Receptor

Cholecystokinin Receptor

COMT

iGluR

Dopamine Receptor

Tau Protein

Dopamine Transporter

FAAH

GABA Receptor

GlyT

GPR119

GPR139

GPR55

Imidazoline Receptor

mAChR

Melanocortin Receptor

Melatonin Receptor

mGluR

Monoamine Oxidase

nAChR

Neurokinin Receptor

Neuropeptide Y Receptor

Neurotensin Receptor

Opioid Receptor

Orexin Receptor (OX Receptor)

Transthyretin (TTR)

Glucosylceramide Synthase (GCS)

α-synuclein

AAK1

Serotonin Transporter

MCHR1 (GPR24)

Sigma Receptor

Somatostatin Receptor

Glucosylceramide Synthase (GCS)

TRK

TRP Channel

β-Amyloid

β-secretase

γ-secretase

Histamine Receptor

Notch
NF-κB Signaling

RANKL/RANK

IKK

Keap1-Nrf2

MALT1

NF-κB

Reactive Oxygen Species

BCMA
Nuclear Receptor Signaling

Thyroid Hormone Receptor (THR)

Androgen Receptor (AR)

Estrogen Receptor (ER)/ERR

Glucocorticoid Receptor (GR)

Mineralocorticoid Receptor (MR)

Progesterone Receptor (PR)

RAR/RXR

PPAR

ROR

Liver X Receptor (LXR)

Vitamin D receptor (VDR)

Pregnane X receptor (PXR)

Nur77

NURR1

REV-ERB

Constitutive androstane receptor (CAR)

Vitamin D/VDR

COUP-TF

HNF4α

Steroidogenic Factor 1 (SF1)

Liver receptor Homolog-1 (LRH-1)

Farnesoid X receptor (FXR)
PI3K/Akt/mTOR

Akt

Akt抑制剂 Akt激活剂 Akt调节剂 AKT诱导剂

AMPK

AMPK激活剂 AMPK抑制剂 AMPK诱导剂

ATM/ATR

DNA-PK

GSK-3

GSK-3抑制剂 GSK-3激活剂

MELK

mTOR

mTOR抑制剂 mTOR激活剂

PDK-1

PI3K

PI3K抑制剂 PI3K激活剂 PI3K调节剂

PI4K

PIKfyve

PTEN

PTEN激活剂 PTEN抑制剂

PDPK1

PIN1

TROP2

LYPD3

CD79B
Protein Tyrosine Kinase/RTK

Ack1

Anaplastic lymphoma kinase (ALK)

Bcr-Abl

BTK

c-Fms

c-Kit

c-Met/HGFR

Ephrin Receptor

BMX Kinase

Discoidin Domain Receptor

DYRK

EGFR

FAK

FGFR

FLT3

HER2

HER3

HER4

IGF-1R

Insulin Receptor

ITK

PDGFR

Pyk2

RET

ROS kinase

SHP2

Src

Syk

TAM Receptor

TRK

VEGFR

JAK

JAK抑制剂 JAK激活剂

Tie
Stem Cell/Wnt

Casein Kinase

ERK

γ-secretase

Gli

GSK-3

GSK-3抑制剂 GSK-3激活剂

Hedgehog

Hippo (MST)

MAP4K

NEDD8-activating Enzyme

Notch

Oct3/4

PKA

Porcupine

ROCK

sFRP-1

Smo

TGF-β/Smad

JAK

JAK抑制剂 JAK激活剂

Wnt/β-catenin

YAP-TEAD

STAT

TROP2

ROR2

MUC16

Sclerostin (SOST)

PTK7
TGF-beta/Smad

PKC

PKC抑制剂 PKC拮抗剂 PKC激活剂 PKC调节剂 PKC激动剂

ROCK

TGF-β Receptor

TGF-β/Smad

PKA
Ubiquitin/Proteasome

Deubiquitinase

E1 Activating

E2 conjugating

E3 ligase

p97

Proteasome

Proteasome抑制剂 Proteasome激活剂 Proteasome调节剂

SUMO
Others

Others

Methylenetetrahydrofolate Dehydrogenase (MTHFD)

Methylenetetrahydrofolate Dehydrogenase (MTHFD)相关产品（2）

货号	产品名	中文名称	产品描述
SJ-MX7088	DS18561882		DS18561882 是一种高效的，对酶具有高选择性的亚甲基四氢叶酸脱氢酶 2 ( MTHFD2) 抑制剂，IC50 值为 0.0063 μM。DS18561882 抑制 MTHFD1 的 IC50 值是 0.57 μM。DS18561882 具有良好的口服药代动力学特性。
SJ-MX5393	LY 345899		LY 345899 是一种叶酸的类似物，也是一种亚甲基四氢叶酸脱氢酶 (MTHFD1; DC301) 和 MTHFD2 抑制剂，其 IC50 值分别为 96 nM 和 663 nM，对 MTHFD1 的 Ki 值为 18 nM。

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