Dihydrofolate reductase (DHFR)

• Anti-infection
  Antibiotic

  Arenavirus

  Bacterial

  CMV

  Enterovirus

  Filovirus

  Fungal

  HBV

  HCV

  HCV Protease

  HIV

  HIV Integrase

  HIV Protease

  HSV

  Influenza Virus

  Orthopoxvirus

  Parasite

  TMV

  Reverse Transcriptase

  RSV

  SARS-CoV

  Virus Protease

  RABV

  HPV

  DENV

  RABV
• Apoptosis
  Apoptosis

  Bcl-2 Family

  Caspase

  Caspase抑制剂 Caspase激活剂 Caspase诱导剂 Caspase调节剂

  c-Myc

  DAPK

  Ferroptosis

  Ferroptosis激活剂 Ferroptosis抑制剂 Ferroptosis诱导剂

  FKBP

  IAP Family

  Survivin

  MDM-2/p53

  PKD

  Necroptosis

  Pyroptosis

  Pyroptosis抑制剂 Pyroptosis激活剂 Pyroptosis诱导剂

  RIP kinase

  RIP kinase 抑制剂

  Thymidylate Synthase

  TNF Receptor

  TNF Receptor抑制剂 TNF Receptor激活剂 TNF Receptor激动剂 TNF Receptor调节剂 TNF Receptor拮抗剂 TNF Receptor诱导剂

  TRADD

  Cuproptosis

  DAPK
• Autophagy
  Autophagy

  FKBP

  LRRK2

  Mitophagy

  Mitophagy抑制剂 Mitophagy激活剂 Mitophagy调节剂 Mitophagy诱导剂

  OGA

  ULK

  ULK抑制剂 ULK激活剂

  Beclin1

  Atg4
• Cell Cycle/DNA Damage
  Antifolate

  APC

  ATM/ATR

  Aurora Kinase

  Aurora Kinase抑制剂 Aurora Kinase调节剂

  BMI-1

  Casein Kinase

  CDK

  Checkpoint Kinase (Chk)

  CRISPR/Cas9

  CRISPR/Cas9激动剂 CRISPR/Cas9激活剂 CRISPR/Cas9诱导剂 CRISPR/Cas9抑制剂

  Deubiquitinase

  DNA Alkylator/Crosslinker

  DNA/RNA Synthesis

  DNA/RNA Synthesis抑制剂 DNA/RNA Synthesis激活剂 DNA/RNA Synthesis激动剂 DNA/RNA Synthesis化学品 DNA/RNA Synthesis拮抗剂 DNA/RNA Synthesis调节剂

  DNA-PK

  Early 2 Factor (E2F)

  Eukaryotic Initiation Factor (eIF)

  GAK

  G-quadruplex

  Haspin Kinase

  HDAC

  HDAC抑制剂 HDAC降解剂 HDAC拮抗剂 HDAC激活剂 HDAC调节剂

  HSP

  HSP抑制剂 HSP拮抗剂 HSP激活剂 HSP激动剂 HSP降解剂 HSP诱导剂

  IRE1

  Kinesin

  LIM Kinase (LIMK)

  Microtubule/Tubulin

  Mps1

  DNA Stain

  Nucleoside Antimetabolite/Analog

  p97

  PAK

  PAK抑制剂 PAK激活剂

  PARP

  PARP抑制剂 PARP激活剂 PARP诱导剂 PARP降解剂

  PERK

  PFKFB3

  Polo-like Kinase (PLK)

  PPAR

  RAD51

  Cyclin G-associated Kinase (GAK)

  ROCK

  ATF6

  Haspin Kinase

  Sirtuin

  Sirtuin抑制剂 Sirtuin激活剂 Sirtuin调节剂 Sirtuin激动剂

  SRPK

  PDI

  Telomerase

  TOPK

  Topoisomerase

  Wee1

  YB-1

  poly (ADP ribose) glycohydrolase (PARG)

  OGG1
• Cytoskeletal Signaling
  Arp2/3 Complex

  Dynamin

  Gap Junction Protein

  Integrin

  Integrin激动剂 Integrin抑制剂 Integrin调节剂 Integrin拮抗剂

  Kinesin

  Microtubule/Tubulin

  Mps1

  Myosin

  Myosin抑制剂 Myosin激活剂 Myosin调节剂

  PAK

  PAK抑制剂 PAK激活剂

  ROCK
• Epigenetics
  AMPK

  AMPK抑制剂 AMPK激活剂 AMPK诱导剂

  Aurora Kinase

  Aurora Kinase抑制剂 Aurora Kinase调节剂

  DNA Methyltransferase

  Epigenetic Reader Domain

  Epigenetic Reader Domain抑制剂 Epigenetic Reader Domain激动剂 Epigenetic Reader Domain降解剂 Epigenetic Reader Domain调节剂 Epigenetic Reader Domain化学品

  HDAC

  HDAC抑制剂 HDAC降解剂 HDAC拮抗剂 HDAC激活剂 HDAC调节剂

  Histone Acetyltransferase

  Histone Acetyltransferase抑制剂 Histone Acetyltransferase降解剂 Histone Acetyltransferase激活剂 Histone Acetyltransferase调节剂

  Histone Demethylase

  Histone Demethylase抑制剂 Histone Demethylase拮抗剂 Histone Demethylase激活剂

  Histone Methyltransferase

  Histone Methyltransferase抑制剂 Histone Methyltransferase降解剂 Histone Methyltransferase拮抗剂 Histone Methyltransferase激活剂 Histone Methyltransferase调节剂 Histone Methyltransferase化学品

  MicroRNA

  PARP

  PARP抑制剂 PARP激活剂 PARP诱导剂 PARP降解剂

  PKC

  PKC激活剂 PKC抑制剂 PKC拮抗剂 PKC调节剂 PKC激动剂

  Protein Arginine Deiminase

  Methionine Adenosyltransferase (MAT)

  Sirtuin

  Sirtuin抑制剂 Sirtuin激活剂 Sirtuin调节剂 Sirtuin激动剂

  JAK

  JAK抑制剂 JAK激活剂

  TET Protein
• GPCR/G Protein
  5-HT Receptor

  5-HT Receptor拮抗剂 5-HT Receptor激动剂 5-HT Receptor抑制剂 5-HT Receptor调节剂 5-HT Receptor激活剂 5-HT Receptor诱导剂

  Adenosine Receptor

  Adenosine Receptor拮抗剂 Adenosine Receptor激动剂 Adenosine Receptor抑制剂 Adenosine Receptor调节剂 Adenosine Receptor激活剂

  Adenylate Cyclase (AC)

  Adrenergic Receptor

  Adrenergic Receptor激动剂 Adrenergic Receptor拮抗剂 Adrenergic Receptor抑制剂 Adrenergic Receptor激活剂 Adrenergic Receptor调节剂

  Angiotensin Receptor

  Bombesin Receptor

  Bradykinin Receptor

  Cannabinoid Receptor

  CaSR

  CCR

  CGRP Receptor

  Cholecystokinin Receptor

  CRFR

  CXCR

  TSH Receptor

  Neuropeptide Y Receptor

  Dopamine Receptor

  EBI2/GPR183

  Endothelin Receptor

  Formyl peptide receptor (FPR)

  GHSR

  Glucagon Receptor

  GNRH Receptor

  GPR109A

  GPR119

  GPR139

  GPR27

  GPR55

  GPR84

  Guanylate Cyclase

  Histamine Receptor

  Imidazoline Receptor

  Leukotriene Receptor

  LPL Receptor

  mAChR

  MCHR1 (GPR24)

  Melanocortin Receptor

  Melatonin Receptor

  mGluR

  Motilin Receptor

  Neurokinin Receptor

  Neurotensin Receptor

  Opioid Receptor

  Orexin Receptor (OX Receptor)

  Oxytocin Receptor

  P2Y Receptor

  PKG

  Prostaglandin Receptor

  Protease-Activated Receptor (PAR)

  Apelin Receptor (APJ)

  Ras

  GPR88

  Free Fatty Acid Receptor

  RGS

  GPR4

  Secretin Receptor

  Mas-related G-protein-coupled Receptor (MRGPR)

  GPR35

  GPR52

  MCHR1 (GPR24)

  Leukotriene Receptor

  GLP Receptor

  Somatostatin Receptor

  Arrestin

  Platelet-activating Factor Receptor (PAFR)

  Mas-related G-protein-coupled Receptor (MRGPR)

  Kisspeptin Receptor

  G Protein-coupled Receptor Kinase (GRK)

  G protein-coupled Bile Acid Receptor 1

  Succinate Receptor 1

  TSH Receptor

  Protease Activated Receptor (PAR)

  Urotensin Receptor

  Vasopressin Receptor

  Motilin Receptor

  TF
• Immunology/Inflammation
  Arginase

  Aryl Hydrocarbon Receptor (AhR)

  CCR

  Complement System

  COX

  CXCR

  Cyclic GMP-AMP Synthase (cGAS)

  TIM-3

  TIGIT

  CTLA-4

  FKBP

  FLAP

  Galectin

  IFNAR

  Interleukin Related

  IRAK

  MIF

  MyD88

  NO Synthase

  NOD-like Receptor (NLR)

  PD-1/PD-L1

  PGE synthase

  CX3CR1

  Pyroptosis

  Pyroptosis抑制剂 Pyroptosis激活剂 Pyroptosis诱导剂

  Nuclear Factor of activated T Cells (NFAT)

  Reactive Oxygen Species

  AP-1

  Salt-inducible Kinase (SIK)

  SOD

  SPHK

  STING

  STING 抑制剂 STING 激动剂

  Thrombopoietin Receptor

  Toll-like Receptor (TLR)

  AP-1

  PSMA

  Glucocorticoid Receptor (GR)

  FAP

  Histamine Receptor

  Macrophage migration inhibitory factor (MIF)

  LAG-3

  Mucin

  Tim3

  Mesothelin

  Nectin-4

  P-selectin

  TROP2

  CD79B

  DPEP3

  BCMA

  MUC16

  BAFF

  CD markers

  FcRn

  CSF2

  IgE

  Glycoprotein VI
• JAK/STAT Signaling
  EGFR

  HER2

  HER3

  HER4

  JAK

  JAK抑制剂 JAK激活剂

  Pim

  STAT

  MUC16
• MAPK Signaling Pathway
  ERK

  JNK

  KLF

  MAP3K

  MAP4K

  MEK

  Mixed Lineage Kinase

  MNK

  p38 MAPK

  Raf

  Ribosomal S6 Kinase (RSK)

  MAPKAPK2 (MK2)

  Macrophage migration inhibitory factor (MIF)

  CD79B

  BCMA
• Membrane Transporter/Ion Channel
  Amino acid transporter

  Aquaporin (AQP)

  ATP synthase

  ATPase

  BCRP

  Calcium Channel

  CFTR

  Chloride Channel

  CRAC Channel

  CRM1

  iGluR

  URAT1

  Piezo Channel

  EAAT

  GABA Receptor

  GLUT

  GlyT

  HCN Channel

  iGluR

  Mechanosensitive channels (MSCs)

  Monoamine Transporter (MAT)

  Monocarboxylate Transporter (MCT)

  Na+/Ca2+ Exchanger

  Na+/HCO3- Cotransporter

  nAChR

  NKCC

  P2X Receptor

  P-glycoprotein

  Potassium Channel

  Proton Pump

  EAAT

  HCN Channel

  SGLT

  Sodium Channel

  Apical Sodium-Dependent Bile Acid Transporter

  TRP Channel

  Na+/K+ ATPase

  Organic Anion Transporting Polypeptide (OATP)

  VDAC

  Na+/H+ Exchanger (NHE)

  NaPi2b

  NaPi2b
• Metabolic Enzyme/Protease
  Glucose Metabolism

  Aldose Reductase Carbonic Anhydrase Enolase FBPase Glucokinase Glucosidase Glutathione Peroxidase Glyoxalase (GLO) Hexokinase HIF/HIF Prolyl-Hydroxylase Lactate Dehydrogenase (LDH) Mineralocorticoid Receptor (MR) Phosphoglycerate Dehydrogenase (PHGDH) PEPCK Pyruvate Kinase SGK Glucose-6-phosphate dehydrogenase (G6PD) NAMPT Mitochondrial Metabolism NADPH Oxidase PGC-1α Phosphatase Reactive Oxygen Species Amylases

  Lipid Metabolism

  11β-HSD 15-PGDH 17β-HSD 5α-reductase Acetyl-CoA carboxylase Acyltransferase Adiponectin Receptor Aldehyde Dehydrogenase (ALDH) ATGL ATP Citrate Lyase Ceramidase CETP Cytochrome P450 DGK Epoxide Hydrolase FAAH FABP Fat Mass and Obesity-associated Protein (FTO) Fatty Acid Synthase (FASN) Farnesoid X receptor (FXR) HMG-CoA Reductase (HMGCR) Isocitrate Dehydrogenase (IDH) LDLR Liposome Liver X Receptor (LXR) MAGL Microsomal Triglyceride Transfer Protein (MTP) PDHK Stearoyl-CoA Desaturase (SCD) ROR REV-ERB RAR/RXR Phospholipase Lipoxygenase Mitochondrial Metabolism NADPH Oxidase PGC-1α Phosphatase Reactive Oxygen Species

  Amino Acid/Protein Metabolism

  Acetolactate Synthase (ALS) Adenosine Deaminase Adenosine Kinase Carboxypeptidase GSNOR MALT1 Methionine Adenosyltransferase (MAT) Furin HCV Protease HIV Protease HPPD Aminopeptidase Angiotensin-converting Enzyme (ACE) Arginase Cathepsin COMT Dipeptidyl Peptidase Dopamine β-hydroxylase Elastase Factor Xa Farnesyl Transferase (FTase) Glutaminase Gutathione S-transferase HSP Indoleamine 2,3-Dioxygenase (IDO) MMP NEDD8-activating Enzyme Neprilysin PAI-1 PDI Procollagen C Proteinase Prolyl Endopeptidase (PREP) Renin Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase Proteasome Ser/Thr Protease Methylenetetrahydrofolate Dehydrogenase (MTHFD) Mitochondrial Metabolism NADPH Oxidase Phosphatase Reactive Oxygen Species

  Nucleic Acid Metabolism

  Aminoacyl-tRNA Synthetase Cryptochrome Dihydrofolate reductase (DHFR) Dihydroorotate Dehydrogenase (DHODH) HIV Integrase Phosphodiesterase (PDE) Methylenetetrahydrofolate Dehydrogenase (MTHFD) NAMPT OGG1

  Drug Metabolite

  Vitamin

  Vitamin A Vitamin B Vitamin C Vitamin D/VDR Vitamin E1 Vitamin K

  Endogenous Metabolite

  Factor VIII

  Factor VIII
• Neuronal Signaling
  5-HT Receptor

  5-HT Receptor拮抗剂 5-HT Receptor激动剂 5-HT Receptor抑制剂 5-HT Receptor调节剂 5-HT Receptor激活剂 5-HT Receptor诱导剂

  Cholinesterase (ChE)

  Adenosine Kinase

  Adrenergic Receptor

  Adrenergic Receptor激动剂 Adrenergic Receptor拮抗剂 Adrenergic Receptor抑制剂 Adrenergic Receptor激活剂 Adrenergic Receptor调节剂

  Calcium Channel

  CaMK

  Cannabinoid Receptor

  CGRP Receptor

  Cholecystokinin Receptor

  COMT

  iGluR

  Dopamine Receptor

  Tau Protein

  Dopamine Transporter

  FAAH

  GABA Receptor

  GlyT

  GPR119

  GPR139

  GPR55

  Imidazoline Receptor

  mAChR

  Melanocortin Receptor

  Melatonin Receptor

  mGluR

  Monoamine Oxidase

  nAChR

  Neurokinin Receptor

  Neuropeptide Y Receptor

  Neurotensin Receptor

  Opioid Receptor

  Orexin Receptor (OX Receptor)

  Transthyretin (TTR)

  Glucosylceramide Synthase (GCS)

  α-synuclein

  AAK1

  Serotonin Transporter

  MCHR1 (GPR24)

  Sigma Receptor

  Somatostatin Receptor

  Glucosylceramide Synthase (GCS)

  TRK

  TRP Channel

  β-Amyloid

  β-secretase

  γ-secretase

  Histamine Receptor

  Notch
• NF-κB Signaling
  RANKL/RANK

  IKK

  Keap1-Nrf2

  MALT1

  NF-κB

  Reactive Oxygen Species

  BCMA
• Nuclear Receptor Signaling
  Thyroid Hormone Receptor (THR)

  Androgen Receptor (AR)

  Estrogen Receptor (ER)/ERR

  Glucocorticoid Receptor (GR)

  Mineralocorticoid Receptor (MR)

  Progesterone Receptor (PR)

  RAR/RXR

  PPAR

  ROR

  Liver X Receptor (LXR)

  Vitamin D receptor (VDR)

  Pregnane X receptor (PXR)

  Nur77

  NURR1

  REV-ERB

  Constitutive androstane receptor (CAR)

  Vitamin D/VDR

  COUP-TF

  HNF4α

  Steroidogenic Factor 1 (SF1)

  Liver receptor Homolog-1 (LRH-1)

  Farnesoid X receptor (FXR)
• PI3K/Akt/mTOR
  Akt

  Akt抑制剂 Akt激活剂 Akt调节剂 AKT诱导剂

  AMPK

  AMPK激活剂 AMPK抑制剂 AMPK诱导剂

  ATM/ATR

  DNA-PK

  GSK-3

  GSK-3抑制剂 GSK-3激活剂

  MELK

  mTOR

  mTOR抑制剂 mTOR激活剂

  PDK-1

  PI3K

  PI3K抑制剂 PI3K激活剂 PI3K调节剂

  PI4K

  PIKfyve

  PTEN

  PTEN激活剂 PTEN抑制剂

  PDPK1

  PIN1

  TROP2

  LYPD3

  CD79B
• Protein Tyrosine Kinase/RTK
  Ack1

  Anaplastic lymphoma kinase (ALK)

  Bcr-Abl

  BTK

  c-Fms

  c-Kit

  c-Met/HGFR

  Ephrin Receptor

  BMX Kinase

  Discoidin Domain Receptor

  DYRK

  EGFR

  FAK

  FGFR

  FLT3

  HER2

  HER3

  HER4

  IGF-1R

  Insulin Receptor

  ITK

  PDGFR

  Pyk2

  RET

  ROS kinase

  SHP2

  Src

  Syk

  TAM Receptor

  TRK

  VEGFR

  JAK

  JAK抑制剂 JAK激活剂

  Tie
• Stem Cell/Wnt
  Casein Kinase

  ERK

  γ-secretase

  Gli

  GSK-3

  GSK-3抑制剂 GSK-3激活剂

  Hedgehog

  Hippo (MST)

  MAP4K

  NEDD8-activating Enzyme

  Notch

  Oct3/4

  PKA

  Porcupine

  ROCK

  sFRP-1

  Smo

  TGF-β/Smad

  JAK

  JAK抑制剂 JAK激活剂

  Wnt/β-catenin

  YAP-TEAD

  STAT

  TROP2

  ROR2

  MUC16

  Sclerostin (SOST)

  PTK7
• TGF-beta/Smad
  PKC

  PKC抑制剂 PKC拮抗剂 PKC激活剂 PKC调节剂 PKC激动剂

  ROCK

  TGF-β Receptor

  TGF-β/Smad

  PKA
• Ubiquitin/Proteasome
  Deubiquitinase

  E1 Activating

  E2 conjugating

  E3 ligase

  p97

  Proteasome

  Proteasome抑制剂 Proteasome激活剂 Proteasome调节剂

  SUMO
• Others
  Others