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信号通路

Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease RABV HPV RABV EBV Dengue Virus β-lactamase Flavivirus VSV Penicillin-binding protein (PBP)
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc DAPK Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis DAPK
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK Beclin1 Atg4 p62 PINK1/Parkin PINK1/Parkin
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1 YB-1 poly (ADP ribose) glycohydrolase (PARG) OGG1 STK33 NEKs ClpP
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK Annexin A
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK TET Protein SF3B1 METTL3 WDR5 Glycosyltransferase
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 TSH Receptor Protease Activated Receptor (PAR) Urotensin Receptor Vasopressin Receptor Motilin Receptor TF RXFP Receptor RGS Protein GPR68 Taste Receptor PACAP Receptor GPR81 GPR171 Trace Amine-associated Receptor (TAAR)
Immunology/Inflammation

Arginase Aryl Hydrocarbon Receptor (AhR) CCR Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 Salt-inducible Kinase (SIK) SOD SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) AP-1 PSMA Glucocorticoid Receptor (GR) FAP Histamine Receptor Macrophage migration inhibitory factor (MIF) LAG-3 Mucin Mesothelin Nectin-4 P-selectin TROP2 DPEP3 BCMA MUC16 BAFF CD markers FcRn CSF2 IgE Glycoprotein VI Kallikrein CD47 BCL6

sFRP-1

分泌型卷曲相关蛋白1（Secreted frizzled related protein 1; SARP-2; FrzA）

分泌型卷曲相关蛋白(secreted frizzled-relatedproteins，sFRPs) 是一类可溶性蛋白质，由 280~ 360 个氨基酸残基组成其蛋白质结构上含有一段极其保守的与Wnt卷曲蛋白受体(Frizzled，Fz)高度同源的半胱氨酸富集区(cysteine-richdomain，CRD)。sFRPs 是第 1 个被鉴定的Wnt信号通路拮抗剂，也是分泌型 Wnt 信号通路拮抗剂的最大家族。

sFRPs 蛋白是一种与跨膜蛋白 Frizzled 家族结构相似的分泌型蛋白质，广泛参与介导细胞间的信息传递。目前，哺乳动物中的 sFRPs 共有 5 种亚型，分别为 sFRP1-5。其中，sFRP3 是原始成员 Frzb 的直系同源物。在序列相关性和系统进化分析方面，sFRP1、sFRP2和 sFRP5 被归为一个子集，而 sFRP3 和 sFRP4 被归类为另一个子集。

最新文献还发现，一直被定义为分泌型蛋白的 sFRPs 作为胞外因子在 Wnt 信号传导中发挥双向调控作用，既可以作为经典Wnt拮抗物抑制 Wnt 信号外，还可以通过促进 Wnt 信号传导的方式参与 Wnt 信号通路介导的生理或病理活动。此外，sFRPs 还能通过外泌体的形式被细胞吸收，并依赖 β-联蛋白进一步转移到细胞核内，与核内 β-联蛋白结合而调控 Wnt 活性。

sFRP-1 相关靶点

全部(1) sFRP-1抑制剂(1)

货号	产品名	中文名称	产品描述
SJ-MX0931	WAY-316606		WAY-316606是一种分泌型 Frizzled-Related Protein-1 (sFRP-1) 抑制剂，是分泌性糖蛋白 Wnt 的拮抗剂，在 FP 结合检测使用中，WAY-316606 作用于 sFRP-1 的 IC50 为 0.5 μM。