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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MN0074 | Bindarit | 宾达利 |
Bindarit (AF 2838) 是一种天然化合物，是单核细胞趋化蛋白 MCP-1/CCL2，MCP-3/CCL7 和 MCP-2/CCL8 的选择性抑制剂，对其他趋化因子如 MIP-1α/CCL3，MIP-1β/CCL4，MIP-3/CCL23 无抑制作用。 |
| SJ-MX0727 | Cenicriviroc (TAK-652) |
Cenicriviroc (CVC, TAK-652, TBR-652) 是一种有效的、口服活性的 CC chemokine receptor 2 (CCR2) 和 CCR5 的双效抑制剂。Cenicriviroc 还可抑制 HIV-1 和 HIV-2 并具有有效的抗炎和抗感染活性。Cenicriviroc是强效免疫调节剂，可以阻止趋化因子受体从而引起肝损害和肝脏疾病。 |
|
| SJ-MA0046 | Maraviroc | 马拉维若 |
Maraviroc (UK-427857) 是一种有效的、选择性 C-C 趋化因子受体 5 型 (CCR5) 拮抗剂药物，旨在通过干扰 HIV 和 CCR5 之间的相互作用来对抗 HIV，具有抑制 HIV 的活性。 |
| SJ-MX3519 | PF-4136309 | PF-4136309 (formerly known as INCB8761) is a novel, potent, selective, and orally bioavailable small molecule CCR2 antagonist with IC50 values of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2, respectively. PF-4136309 exhibited potent CCR2 antagonistic activity, high selectivity, weak hERG activity, and an excellent in vitro and in vivo ADMET profile. PF-4136309 has entered human clinical trials. Currently, PF-4136309 has been completed in phase I study for the treatment of pancreatic neoplasms, but no results posted. | |
| SJ-MX4018 | R243 | R243 is an inhibitor of CCR8 signaling and chemotaxis. | |
| SJ-MX0329 | RS 504393 |
RS 504393 是一种选择性的 CCR2 拮抗剂，IC50为98 nM，当给药浓度较高时，也可靶向趋化因子受体2b（CC chemokine receptor 2b，CCR2b） 和趋化因子受体1（CC chemokine receptor 1，CCR1）进行抑制。 |
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| SJ-MX2909 | RS102895 hydrochloride | RS-102895 hydrochloride, the hydrochloride salt of RS102895, is a novel and potent chemokine receptor CCR2 antagonist with an IC50 of 360 nM, it shows no effect on CCR1. RS-102895 hydrochloride blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. It also inhibits α1A, α1D and 5-HT1A receptors. | |
| SJ-MX3570 | BX471 | BX471 (ZK-811752,BX-471) is a potent and selective non-peptide CCR1 antagonist with a Ki of 1 nM; displays 250-fold selectivity for CCR1 over CCR2, CCR5 and CXCR4. | |
| SJ-MX3570A | BX471 hydrochloride | BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4. | |
| SJ-MX2113 | BMS-813160 | BMS-813160 是一种双重 CCR2/CCR5 拮抗剂。有潜力用于心血管的研究。 | |
| SJ-MX0008 | AZD2098 | AZD2098 是一种有效、选择性的 CCR4 抑制剂，作用于人类、大鼠、小鼠、狗的 CCR4 pIC50s 值分别为 7.8、8.0、8.0、7.6，可用于哮喘研究。 | |
| SJ-MX4128 | AZD-4818 | AZD-4818 (AZD 4818) is a novel and potent chemokine CCR1 antagonist ,it is used for the treatment of chronic obstructive pulmonary disease. | |
| SJ-MX0731 | SB-297006 |
SB-297006 是一种 C-C chemokine receptor 3 (CCR3) 的拮抗剂，IC50 = 39 nM，对 CCR3 的选择性是其他趋化因子受体的 250 倍，包括 CXCR1、CXCR2、CCR1 和 CCR7 (IC50 >27 μM)。SB-297006可抑制抗原诱导的T(h)2和嗜酸性粒细胞在肺中的累积。SB-297006 能够显著抑制 CCL11 处理的神经祖细胞的增殖和神经球形成。 |
|
| SJ-MX0684 | Pirfenidone | 哌非尼酮 |
Pirfenidone (S-7701, AMR-69) 抑制 TGF-β 产生和 TGF-β 刺激的胶原蛋白产生，且降低 TNF-α 和 IL-1β 产生，具有抗氧化和抗炎特性。Pirfenidone 可减弱 chemokine（CC motif）ligand-2 （CCL2）和 CCL12 的生成，并具有抗纤维化的活性。 |
| SJ-BP0213 | DAPTA | Adaptavir, also known as RAP-101, DAPTA, and mDAPTA, is a CCR5 receptor antagonist potentially for the treatment of HIV infection and HBV infection. | |
| SJ-MX5657 | INCB3344 | ||
| SJ-MX5757 | CCR2 antagonist 4 hydrochloride | ||
| SJ-MX5770 | TAK-779 | ||
| SJ-MX5790 | CCR7 Ligand 1 |
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