信号通路

• Anti-infection
  Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease RABV HPV RABV EBV Dengue Virus β-lactamase Flavivirus VSV Penicillin-binding protein (PBP)
• Apoptosis
  Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis DAPK Disulfidptosis
• Autophagy
  Autophagy FKBP LRRK2 Mitophagy OGA ULK Beclin1 Atg4 p62 PINK1/Parkin
• Cell Cycle/DNA Damage
  Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1 YB-1 poly (ADP ribose) glycohydrolase (PARG) OGG1 STK33 NEKs ClpP
• Cytoskeletal Signaling
  Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK Annexin A
• Epigenetics
  AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK TET Protein SF3B1 METTL3 WDR5 Glycosyltransferase
• GPCR/G Protein
  5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 Protease Activated Receptor (PAR) Urotensin Receptor Vasopressin Receptor Motilin Receptor TF RXFP Receptor RGS Protein GPR68 Taste Receptor PACAP Receptor GPR81 GPR171 Trace Amine-associated Receptor (TAAR)
• Immunology/Inflammation
  Arginase Aryl Hydrocarbon Receptor (AhR) CCR Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 Salt-inducible Kinase (SIK) SOD SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) PSMA Glucocorticoid Receptor (GR) FAP Histamine Receptor Macrophage migration inhibitory factor (MIF) LAG-3 Mucin Mesothelin Nectin-4 P-selectin TROP2 DPEP3 BCMA MUC16 BAFF CD markers FcRn CSF2 IgE Glycoprotein VI Kallikrein CD47 BCL6

• JAK/STAT Signaling
  EGFR HER2 HER3 HER4 JAK Pim STAT MUC16
• MAPK Signaling Pathway
  ERK JNK KLF MAP3K MAP4K MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK) MAPKAPK2 (MK2) Macrophage migration inhibitory factor (MIF) BCMA
• Membrane Transporter/Ion Channel
  Amino acid transporter Aquaporin (AQP) ATP synthase ATPase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 iGluR URAT1 Piezo Channel EAAT GABA Receptor GLUT GlyT Mechanosensitive channels (MSCs) Monoamine Transporter (MAT) Monocarboxylate Transporter (MCT) Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter nAChR NKCC P2X Receptor P-glycoprotein Potassium Channel Proton Pump HCN Channel SGLT Sodium Channel Apical Sodium-Dependent Bile Acid Transporter TRP Channel Organic Anion Transporting Polypeptide (OATP) VDAC Na+/H+ Exchanger (NHE) NaPi2b ASCT Calmodulin Anion Exchangers
• Metabolic Enzyme/Protease
  Glucose Metabolism Lipid Metabolism Amino Acid/Protein Metabolism Nucleic Acid Metabolism Drug Metabolite Vitamin Endogenous Metabolite
• Neuronal Signaling
  5-HT Receptor Cholinesterase (ChE) Adenosine Kinase Adrenergic Receptor Calcium Channel CaMK Cannabinoid Receptor CGRP Receptor Cholecystokinin Receptor COMT iGluR Dopamine Receptor Tau Protein Dopamine Transporter FAAH GABA Receptor GlyT GPR119 GPR139 GPR55 Imidazoline Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Monoamine Oxidase nAChR Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Transthyretin (TTR) Glucosylceramide Synthase (GCS) α-synuclein AAK1 Serotonin Transporter MCHR1 (GPR24) Sigma Receptor Somatostatin Receptor TRK TRP Channel β-Amyloid β-secretase γ-secretase Histamine Receptor Notch PINK1/Parkin OGT
• NF-κB Signaling
  RANKL/RANK IKK Keap1-Nrf2 MALT1 NF-κB Reactive Oxygen Species BCMA
• Nuclear Receptor Signaling
  Thyroid Hormone Receptor (THR) Androgen Receptor (AR) Estrogen Receptor (ER)/ERR Glucocorticoid Receptor (GR) Mineralocorticoid Receptor (MR) Progesterone Receptor (PR) RAR/RXR PPAR ROR Liver X Receptor (LXR) Pregnane X receptor (PXR) Nur77 NURR1 REV-ERB Constitutive androstane receptor (CAR) Vitamin D/VDR COUP-TF HNF4α Steroidogenic Factor 1 (SF1) Liver receptor Homolog-1 (LRH-1) Farnesoid X Receptor (FXR) TSH Receptor
• PI3K/Akt/mTOR
  Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN PDPK1 PIN1 TROP2 LYPD3 FOXO
• Protein Tyrosine Kinase/RTK
  Ack1 Anaplastic lymphoma kinase (ALK) Bcr-Abl BTK c-Fms c-Kit c-Met/HGFR Ephrin Receptor BMX Kinase Discoidin Domain Receptor DYRK EGFR FAK FGFR FLT3 HER2 HER3 HER4 IGF-1R Insulin Receptor ITK PDGFR Pyk2 RET ROS kinase SHP2 Src Syk TAM Receptor TRK VEGFR JAK Tie
• Stem Cell/Wnt
  Casein Kinase ERK γ-secretase Gli GSK-3 Hedgehog Hippo (MST) MAP4K NEDD8-activating Enzyme Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo TGF-β/Smad JAK Wnt/β-catenin YAP-TEAD STAT TROP2 ROR2 MUC16 Sclerostin (SOST) PTK7 Organoid
• TGF-beta/Smad
  PKC ROCK TGF-β Receptor TGF-β/Smad PKA
• Ubiquitin/Proteasome
  Deubiquitinase E1 Activating E2 conjugating E3 ligase p97 Proteasome SUMO
• Others
  Others Amino Acid Derivatives