您当前的位置：

信号通路

Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog Nur77 p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) Nucleoside Antimetabolite/AnalogOrthopoxvirus ROCK ATF6 Haspin Kinase Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Endocrinology/Hormones

Adrenergic Receptor Androgen Receptor Angiotensin-converting Enzyme (ACE) Aromatase Cholecystokinin Receptor TSH Receptor Estrogen Receptor/ERR GHSR Glucocorticoid Receptor GNRH Receptor Mineralocorticoid Receptor Opioid Receptor PGD synthase PGE synthase Progesterone Receptor Thyroid Hormone Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain FTO HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR27 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor E3 Ligase Ligand-Linker Conjugates RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Vasopressin Receptor

-收起全部分类

Drug Metabolite

Drug Metabolite相关产品（25）

货号	产品名	中文名称	产品描述
SJ-MN0048	Mycophenolate Mofetil	吗替麦考酚酯	Mycophenolate Mofetil是一种免疫抑制性药物前体，通过肠和血液中的酯酶水解释放霉酚酸（MPA）。Mycophenolate mofetil 是一种非竞争性的，选择性的，可逆的肌苷一磷酸脱氢酶亚型（inosine monophosphate dehydrogenase，IMPDH） I/II抑制剂，IC50分别为39 nM和27 nM。Mycophenolate mofetil 显示出选择性淋巴细胞抗增殖作用，涉及 T 细胞和 B 细胞，防止抗体形成。
SJ-MN0108	monomethyl fumarate	富马酸单甲酯	Monomethyl fumarate 是 Dimethyl fumarate (DMF) 的活性代谢产物，一种有效的 GPR109A 激动剂。Monomethyl fumarate 具有用于多种神经保护途径和其他视网膜疾病模型的潜力。
SJ-MX2030	Clofibric acid	对氯苯氧异丁酸	Clofibric acid (Chlorofibrinic acid)，一种脂质纤维调节剂 Clofibrate，Etofibrate 和 Etofyllinclofibrate 活性代谢物，是 PPARα的激动剂，具有降血脂作用。Clofibric acid 也是一种除草剂。
SJ-MX3776	Nicotinamide N-oxide	烟酰胺-N-氧化物	Nicotinamide N-oxide是生物体内烟酰胺分解代谢物, 是高效选择性的CXCR2受体拮抗剂。
SJ-MN1552	Hydroxy Itraconazole	羟基伊曲康唑	Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) 是 Itraconazole (ITZ) 的活性代谢物，Itraconazole 是一种三唑类抗真菌剂。
SJ-MX4634	Cycloguanil hydrochloride	环氯胍盐酸盐	Cycloguanil hydrochloride是proguanil的一种活性代谢物，作用于红细胞和肝细胞中的疟疾裂殖体。
SJ-MX4657	Endoxifen hydrochloride	因多昔芬盐酸盐	Endoxifen hydrochloride is the metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM); Potently inhibits the growth of estrogen-stimulated BT474 cells (IC50: 54 nM).
SJ-MX1339	Nortriptyline hydrochloride	去甲替林盐酸盐	Nortriptyline hydrochloride (Desmethylamitriptyline hydrochloride) 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢产物，用于缓解抑郁症症状。Nortriptyline hydrochloride 是有效自噬 (autophagy ) 抑制剂。
SJ-MN0699	Vinburnine		Vinburnine, formerly known as Eburnamonine, is a vasodilator. Vinburnine is a vinca alkaloid and a metabolite of vincamine.
SJ-MB0010	Ampyrone	4-氨基安替吡啉	Ampyrone is a metabolite of AMINOPYRINE with analgesic and anti-inflammatory properties. It is used as a reagent for bioactive compound reactions producing peroxides or phenols. Ampyrone stimulates LIVER MICROSOMES and is also used to measure extracellular water.
SJ-MN0831	(±)-Equol	(±)-雌马酚	Equol (racemic), the racemic mixture of equol, is a drug is potentially for the treatment of acute thyroid disease and inhibits proliferation of human gastric carcinoma cells. Equol (racemic) is a mixture of S-equol and R-equol.
SJ-MA0211	Oseltamivir acid	奥斯他伟酸	Oseltamivir acid (GS 4071)，Oseltamivir phosphate 的活性代谢产物, 是流感病毒神经氨酸酶 (IC50=2 nM) 的口服生物有效的，选择性的抑制剂，对流感病毒 A 和 B 都有活性。
SJ-MN0067	Urolithin A	尿石素A	Urolithin A是鞣花酸的肠道微生物代谢产物，具有抗炎、抗增殖和抗氧化的特性。Urolithin A 诱导自噬（autophagy）和凋亡（apoptosis），抑制细胞周期进程，抑制 DNA 合成。
SJ-MX4248	p-Coumaric Acid Ethyl Ester		p-Coumaric Acid Ethyl Ester (Ethyl (E)-p-hydroxycinnamate; Ethyl trans-4-hydroxycinnamate)是 p-Coumaric acid 的乙酯形式。p-Coumaric Acid 可用于自身免疫性炎性疾病 (如类风湿关节炎) 的研究，是一种免疫抑制剂。
SJ-MX1562	Penicillamine	青霉胺	Penicillamine (D-(-)-Penicillamine) 是 penicillin 的代谢降解产物，可作为螯合剂，作用于威尔逊氏病。
SJ-MN1001	Homoeriodictyol		Homoeriodictyol 是 Eriocitrin 的黄酮类代谢物。Eriocitrin 是一种强效抗氧化剂。
SJ-MX2660	Molsidomine	吗多明	Molsidomine is a NO donor and annexin A2 inhibitor. It inhibits PDGF-induced smooth muscle cell migration, suppresses carotid artery neointima formation, and prevents activated platelet adhesion.
SJ-MA0219	GS-443902	瑞德西韦代谢物	GS-443902 (GS-441524 triphosphate) 是一种有效的病毒 RNA 依赖的 RNA 聚合酶 (RdRp) 抑制剂，对 RSV RdRp 和 HCV RdRp 的 IC50 分别为 1.1 µM 和 5 µM。GS-443902 是 Remdesivir 的活性三磷酸盐代谢产物。
SJ-MX4376	Palifosfamide	帕利伐米	Palifosfamide是异环磷酰胺（IFA）的活性部分。IFA是烷化剂，在各种儿科肉瘤中发挥活性，如横纹肌肉瘤（RMS）、尤因氏肉瘤（ES）、骨肉瘤（OS）和其它未分化软组织肉瘤。
SJ-MX4614	N-Desmethylclozapine	N-去甲基氯氮平	N-Desmethylclozapine 是Clozapine 的主要活性代谢产物，已知具有抗精神病作用。N-Desmethylclozapine 是一种有效的、变构的部分 M1 受体激动剂 (EC50=115 nM)，能通过 M1 受体激活增强海马 N-methyl-d-aspartate (NMDA) 受体电流。N-Desmethylclozapine 也是 δ-opioid 激动剂。部分激动剂，同时是有效的 5-HT 2 5-羟色胺受体拮抗剂。