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Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease RABV HPV DENV RABV
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc DAPK Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis DAPK
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK Beclin1 Atg4
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog p97 PAK PARP PERK PFKFB3 Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1 YB-1 poly (ADP ribose) glycohydrolase (PARG) OGG1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK TET Protein
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Mas-related G-protein-coupled Receptor (MRGPR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 TSH Receptor Protease Activated Receptor (PAR) Urotensin Receptor Vasopressin Receptor Motilin Receptor TF
Immunology/Inflammation

Arginase Aryl Hydrocarbon Receptor (AhR) CCR Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 Salt-inducible Kinase (SIK) SOD SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) AP-1 PSMA Glucocorticoid Receptor (GR) FAP Histamine Receptor Macrophage migration inhibitory factor (MIF) LAG-3 Mucin Tim3 Mesothelin Nectin-4 P-selectin TROP2 CD79B DPEP3 BCMA MUC16 BAFF CD markers FcRn CSF2 IgE Glycoprotein VI

Pyroptosis

Pyroptosis 相关靶点

全部(8) Pyroptosis抑制剂(5) Pyroptosis激活剂(1) Pyroptosis诱导剂(1)

货号	产品名	中文名称	产品描述
SJ-BP0030	Ac-FLTD-CMK		Ac-FLTD-CMK 是胃泌素 D (GSDMD) 衍生的抑制剂，是炎症性 caspases 的特异性抑制剂。Ac-FLTD-CMK 对 caspases-1 (IC50 为 46.7 nM)，caspases-4 (IC50 为 1.49 μM)，caspases-5 (IC50 为 329 nM) 和 caspases-11 均有效，但对凋亡相关的 caspase-3 无效。
SJ-MX0643	Disulfiram	双硫仑	Disulfiram (Tetraethylthiuram disulfide) 是特异性的乙醛脱氢酶 1 型抗体 (ALDH1) 抑制剂，对酒精具有急性敏感性。Disulfiram 有效抑制人体和小鼠细胞中脂质体中的 GSDMD 孔形成、炎性体介导的细胞凋亡和 IL-1β 分泌。Disulfiram 也可以将铜输送到细胞中，诱导铜凋亡。Disulfiram 可以穿过 BBB，在胶质母细胞瘤患者的临床试验中具有抗癌和/或化疗增敏作用。Disulfiram 和 Cu 共同治疗还可以降低肿瘤抑制基因 PTEN 的表达并激活人类乳腺癌中的 AKT 信号传导，增加细胞内 ROS 水平，引发卵巢癌干细胞凋亡。
SJ-MX4094	LDC7559		LDC7559 是一种消皮素 D (GSDMD) 的抑制剂，通过抑制中性粒细胞胞外杀菌网络 (NET) 后期阶段而发挥作用。LDC7559 可抑制焦亡并减轻其炎症。
SJ-MN0852	Morroniside	莫诺苷	Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用。
SJ-MN0841	Polyphyllin VI	重楼皂苷VI	Polyphyllin VI，一种活性皂甙，具有抗癌活性。Polyphyllin VI 诱导 G2/M 细胞周期停滞并引发细胞凋亡。Polyphyllin VI 通过诱导非小细胞肺癌中的 ROS/NF-κB/NLRP3/GSDMD 信号轴来诱导 caspase-1 介导的细胞焦亡 (pyroptosis)。
SJ-MX4487	Triclabendazole	三氯苯达唑	Triclabendazole 是一种苯并咪唑类化合物，它与微管蛋白结合，损害细胞内运输机制，且干扰蛋白质的合成。Triclabendazole 是有口服活性的寄生虫 (parasite) 抑制剂。Triclabendazole 具有抗利什曼原虫 (*Leishmania) 活性，并通过激活 caspase-3* 诱导 gasdermin E (GSDME) 依赖的细胞焦亡 (pyroptosis)，可用于肝片吸虫研究。
SJ-MN0999	Ethyl pyruvate	丙酮酸乙酯	Ethyl pyruvate (CTI-01) 是丙酮酸一种简单的脂肪族酯，通过发挥消炎、抗氧化和抗凋亡活性而具有神经保护作用。
SJ-MX6201	2-Bromohexadecanoic acid	2-溴十六烷酸	2-Bromohexadecanoic acid (2-BP, 2-bromopalmitate) 是一种不可代谢的棕榈酸酯类似物，可作为棕榈酰化 (palmitoylation) 抑制剂，抑制棕榈酰基转移酶 (PAT) 对 MyrGCK (NBD) 和 FarnCNRas (NBD) 的活性，IC50 均接近 4 µM。2-Bromohexadecanoic acid 可直接且不可逆地抑制所有 DHHC (Asp-His-His-Cys) 蛋白的棕榈酰转移酶活性。