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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MX2640 | Liranaftate | 利拉萘酯 | Liranaftate (Piritetrate) 是一种具有抗真菌活性的角鲨烯环氧酶抑制剂。Liranaftate 可用于皮肤癣菌的研究。Liranaftate 还能抑制真菌元素促进的 IL-8 产生和实验性炎症。 |
| SJ-MA0359 | Efinaconazole | 艾氟康唑 | Efinaconazole is a topical antifungal that inhibits sterol 14α-demethylase, an enzyme in the ergosterol biosynthesis pathway. Efinaconazole has lower minimum inhibitory concentrations than terbinafine, ciclopirox, itraconazole and amorolfine in Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans. |
| SJ-MN0743 | Cyclosporin C | ||
| SJ-MA0191A | Terbinafine hydrochloride | 盐酸特比萘芬 | Terbinafine hydrochloride is a selective TASK3 (TWIK-related acid-sensitive K⁺ channel 3, KCNK9, K2P9.1) activator (pEC₅₀ = 6.2). It displays >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). Also acts as a broad-spectrum antifungal agent; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase. |
| SJ-MA0236 | Amorolfine hydrochloride | 盐酸阿莫罗芬 | Amorolfine hydrochloride (Ro 14-4767/002), a topically administered drug, is a potent and broad-spectrum antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation. Amorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h. |
| SJ-MA0283 | Fenticonazole Nitrate | 硝酸芬替康唑 | Fenticonazole Nitrate is an azole class of antifungal drug used locally as the nitrate form for the treatment of vulvovaginal candidiasis. It is a 14-α demethylase inhibitor and potentially a glucosamine-6-phosphate synthase inhibitor. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans. Application of fenticonazole nitrate 1 g intravaginal ovules on 2 alternate days is a suitable first-line treatment of vulvovaginitis with acceptable broad-spectrum efficacy against the most commonly involved pathogens and with a low rate of early relapse, reserving antibiotics for patients with treatment failure or relapse of infection . |
| SJ-MA0293 | Hexetidine | 海克替啶 | Hexetidine (NSC17764; NSC-17764) is an orally active antiseptic with broad antibacterial and antifungal activity. Hexetidine give important potential for treatment of oral infections. |
| SJ-MA0296 | Isoconazole nitrate | 硝酸异康唑 | Isoconazole nitrate is an azole antifungal drug and could inhibit gram positive bacteria. Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability. |
| SJ-MA0301 | Thifluzamide | 噻呋酰胺 | Thifluzamide is a succinate dehydrogenase inhibitor (SDHI) with strong antifungal activity. |
| SJ-MA0302 | Luliconazole | 卢立康唑 | Luliconazole (also known as NND-502; NND502; Luzu) is an imidazole-based antifungal drug that is used for the topical treatment of interdigital tinea pedis. Luliconazole is a broad-spectrum antifungal agent that inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). As a 1% topical cream, it is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporum gypseum and Epidermophyton floccosum. |
| SJ-MA0310 | Naftifine hydrochloride | 盐酸萘替芬 | Naftifine hydrochloride is an allylamine compound that displays antifungal and antimycotic activities. It inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also shows antibiotic activity against Gram-positive and Gram-negative bacteria. |
| SJ-MA0322 | Phenothiazine | 吩噻嗪 | Phenothiazine (NSC 2037; ENT38; ENT 38; NSC-2037) is a potent dopamine-2 (D2) receptor antagonist used as antipsychotic medications for the treatment of schizophrenia and manifestations of psychotic disorders. It acts by inhibiting dopamine-2 (D2) receptor, thus decreasing the effect of dopamine in the brain. |
| SJ-MA0343 | Tolnaftate | 托萘酯 | Tolnaftate (NP-27) 是合成的硫代氨基甲酸酯类抗真菌化合物。 |
| SJ-MA0372 | Clotrimazole | 克霉唑 |
Clotrimazole 是咪唑衍生物，一种口服广谱抗真菌药物。Clotrimazole 抑制微粒体细胞色素P450 (CYP450)依赖性事件14-α-羊毛甾醇去甲基化，这是真菌生物合成麦角甾醇的重要步骤。Clotrimazole 还具有抗菌活性。 |
| SJ-MA0375 | Tioconazole | 噻康唑 | Tioconazole (UK-20349) 是一种广谱性的抗真菌咪唑衍生物。Tioconazole 抑制几种皮肤真菌和几种酵母菌的 MIC50 分别小于 3.12 mg/L 和 9 mg/L。 |
| SJ-MA0392 | Butoconazole nitrate | 硝酸布康唑 | Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物，对念珠菌属有活性，对白色念珠菌引起的阴道感染有效。Butoconazole nitrate 被认为可通过抑制类固醇合成而起其他咪唑衍生物的作用。 |
| SJ-MH0049 | Flumethasone | 氟米松 | Flumethasone is a Selective and potent topical glucocorticoid receptor agonist (IC50 value 0.26 nM for human GR). For the treatment of various allergic, inflammatory, and autoimmune disorders. |
| SJ-MN0404 | Xanthoxylin | 花椒素 | Xanthoxylin (Xanthoxyline) 是从 Zanthoxylum simulans 中分离出来的。 Xanthoxylin (Xanthoxyline) 具有抗真菌 (antifungal) 和抗癫痫作用。 |
| SJ-MN0705 | Geraniol | 香叶醇 | Geraniol is a monoterpenoid and an alcohol. It is the primary component of rose oil, palmarosa oil, and citronella oil. It is a colorless oil, although commercial samples can appear yellow. |
| SJ-MN0711 | Lapachol | Lapachol has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is inhibitor of epithelial tumors in Drosophila melanogaster heterozygote. |
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