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Fungal

Fungal相关产品(164)
货号 产品名 中文名称 产品描述
SJ-MX2640 Liranaftate 利拉萘酯 Liranaftate (Piritetrate) 是一种具有抗真菌活性的角鲨烯环氧酶抑制剂。Liranaftate 可用于皮肤癣菌的研究。Liranaftate 还能抑制真菌元素促进的 IL-8 产生和实验性炎症。
SJ-MA0359 Efinaconazole 艾氟康唑 Efinaconazole is a topical antifungal that inhibits sterol 14α-demethylase, an enzyme in the ergosterol biosynthesis pathway. Efinaconazole has lower minimum inhibitory concentrations than terbinafine, ciclopirox, itraconazole and amorolfine in Trichophyton rubrum, Trichophyton mentagrophytes and Candida albicans.
SJ-MN0743 Cyclosporin C
SJ-MA0191A Terbinafine hydrochloride 盐酸特比萘芬 Terbinafine hydrochloride is a selective TASK3 (TWIK-related acid-sensitive K⁺ channel 3, KCNK9, K2P9.1) activator (pEC₅₀ = 6.2). It displays >10-fold selectivity for TASK3 over TREK2, TRESK, THIK1 and TASK2. Also inhibits TWIK1 (pIC50 = 5.69). Also acts as a broad-spectrum antifungal agent; inhibits fungal sterol biosynthesis by inhibition of squalene epoxidase.
SJ-MA0236 Amorolfine hydrochloride 盐酸阿莫罗芬 Amorolfine hydrochloride (Ro 14-4767/002), a topically administered drug, is a potent and broad-spectrum antifungal agent with fungicidal effects against most fungi, dermatophytes and yeasts. Amorolfine blocks ergosterol biosynthesis by interfering with delta 14 reduction and the delta 7-8 isomerisation. Amorolfine is an antifungal showing activity against fungi pathogenic to plants, animals and humans. At 0.2, 2 and 5 micrograms/ml amorolfine did not have any significant inhibitory or enhancing effect on phagocytosis whether following simultaneous addition of blastospores and drug to the neutrophils, prior treatment of neutrophils for 2 h before addition of blastospores or prior treatment of blastospores for 2 h.
SJ-MA0283 Fenticonazole Nitrate 硝酸芬替康唑 Fenticonazole Nitrate is an azole class of antifungal drug used locally as the nitrate form for the treatment of vulvovaginal candidiasis. It is a 14-α demethylase inhibitor and potentially a glucosamine-6-phosphate synthase inhibitor. It is active against a range of organisms including dermatophyte pathogens, Malassezia furfur, and Candida albicans. Application of fenticonazole nitrate 1 g intravaginal ovules on 2 alternate days is a suitable first-line treatment of vulvovaginitis with acceptable broad-spectrum efficacy against the most commonly involved pathogens and with a low rate of early relapse, reserving antibiotics for patients with treatment failure or relapse of infection .
SJ-MA0293 Hexetidine 海克替啶 Hexetidine (NSC17764; NSC-17764) is an orally active antiseptic with broad antibacterial and antifungal activity. Hexetidine give important potential for treatment of oral infections.
SJ-MA0296 Isoconazole nitrate 硝酸异康唑 Isoconazole nitrate is an azole antifungal drug and could inhibit gram positive bacteria. Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.
SJ-MA0301 Thifluzamide 噻呋酰胺 Thifluzamide is a succinate dehydrogenase inhibitor (SDHI) with strong antifungal activity.
SJ-MA0302 Luliconazole 卢立康唑 Luliconazole (also known as NND-502; NND502; Luzu) is an imidazole-based antifungal drug that is used for the topical treatment of interdigital tinea pedis. Luliconazole is a broad-spectrum antifungal agent that inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). As a 1% topical cream, it is indicated for the treatment of athlete's foot, jock itch, and ringworm caused by dermatophytes such as Trichophyton rubrum, Microsporum gypseum and Epidermophyton floccosum.
SJ-MA0310 Naftifine hydrochloride 盐酸萘替芬 Naftifine hydrochloride is an allylamine compound that displays antifungal and antimycotic activities. It inhibits fungal squalene epoxidase and prevents ergosterol biosynthesis. Naftifine also shows antibiotic activity against Gram-positive and Gram-negative bacteria.
SJ-MA0322 Phenothiazine 吩噻嗪 Phenothiazine (NSC 2037; ENT38; ENT 38; NSC-2037) is a potent dopamine-2 (D2) receptor antagonist used as antipsychotic medications for the treatment of schizophrenia and manifestations of psychotic disorders. It acts by inhibiting dopamine-2 (D2) receptor, thus decreasing the effect of dopamine in the brain.
SJ-MA0343 Tolnaftate 托萘酯 Tolnaftate (NP-27) 是合成的硫代氨基甲酸酯类抗真菌化合物。
SJ-MA0372 Clotrimazole 克霉唑

Clotrimazole 是咪唑衍生物,一种口服广谱抗真菌药物。Clotrimazole 抑制微粒体细胞色素P450 (CYP450)依赖性事件14-α-羊毛甾醇去甲基化,这是真菌生物合成麦角甾醇的重要步骤。Clotrimazole 还具有抗菌活性。

SJ-MA0375 Tioconazole 噻康唑 Tioconazole (UK-20349) 是一种广谱性的抗真菌咪唑衍生物。Tioconazole 抑制几种皮肤真菌和几种酵母菌的 MIC50 分别小于 3.12 mg/L 和 9 mg/L。
SJ-MA0392 Butoconazole nitrate 硝酸布康唑 Butoconazole nitrate (RS 35887) 是一种咪唑类抗真菌药物,对念珠菌属有活性,对白色念珠菌引起的阴道感染有效。Butoconazole nitrate 被认为可通过抑制类固醇合成而起其他咪唑衍生物的作用。
SJ-MH0049 Flumethasone 氟米松 Flumethasone is a Selective and potent topical glucocorticoid receptor agonist (IC50 value 0.26 nM for human GR). For the treatment of various allergic, inflammatory, and autoimmune disorders.
SJ-MN0404 Xanthoxylin 花椒素 Xanthoxylin (Xanthoxyline) 是从 Zanthoxylum simulans 中分离出来的。 Xanthoxylin (Xanthoxyline) 具有抗真菌 (antifungal) 和抗癫痫作用。
SJ-MN0705 Geraniol 香叶醇 Geraniol is a monoterpenoid and an alcohol. It is the primary component of rose oil, palmarosa oil, and citronella oil. It is a colorless oil, although commercial samples can appear yellow.
SJ-MN0711 Lapachol Lapachol has antimicrobial properties against many pathogens. It has anti-inflammatory, analgesic and antibiotic properties. It is inhibitor of epithelial tumors in Drosophila melanogaster heterozygote.