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Gli抑制剂

Anti-infection

Antibiotic

Bacterial

Bacterial β-lactamase Penicillin-binding protein (PBP)

Fungal

Parasite

Virus

Arenavirus CMV Dengue Virus EBV Enterovirus Filovirus Flavivirus HBV HCV HCV Protease HIV HIV Integrase HIV Protease HPV HSV Influenza Virus Orthopoxvirus RABV Reverse Transcriptase RSV SARS-CoV TMV Virus Protease VSV
Apoptosis

Apoptosis

Extrinsic Pathway

Bcl-2 Family Caspase DAPK FKBP PKD RIP kinase TNF Receptor TRADD

Intrinsic Pathway

ASK1 Bcl-2 Family Caspase c-Myc FKBP IAP Family MDM-2/p53 Survivin Thymidylate Synthase

Ferroptosis

Cuproptosis Ferroptosis Glutathione Peroxidase

Necrotic Cell Death

Necroptosis Pyroptosis

Disulfidptosis
Autophagy

Autophagy

ATTECs AUTACs Autophagy Mitophagy

Atg and Atg-related Protein

Atg4 Beclin1 FKBP LRRK2 p62 PINK1/Parkin ULK
Cell Cycle/DNA Damage

Cell Cycle

Antifolate APC Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Cyclin G-associated Kinase (GAK) DNA/RNA Synthesis Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) G-quadruplex Haspin Kinase HDAC Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 NEKs Nucleoside Antimetabolite/Analog PAK Polo-like Kinase (PLK) poly (ADP ribose) glycohydrolase (PARG) PPAR ROCK Sirtuin SRPK STK33 Telomerase TOPK Topoisomerase Wee1 YB-1

DNA Damage

ATM/ATR Aurora Kinase BMI-1 Casein Kinase CRISPR/Cas9 DNA Alkylator/Crosslinker DNA Stain DNA/RNA Synthesis DNA-PK HSP NEKs Nucleoside Antimetabolite/Analog OGG1 p97 PARP RAD51 YB-1

Unfolded Protein Response

ATF6 ClpP CRISPR/Cas9 Deubiquitinase Eukaryotic Initiation Factor (eIF) HSP IRE1 PDI PERK
Cytoskeletal Signaling

Arp2/3 Complex

Dynamin

Gap Junction Protein

Integrin

Integrin抑制剂 Integrin拮抗剂 Integrin激动剂 Integrin调节剂 Integrin其他

Kinesin

Microtubule/Tubulin

Mps1

Myosin

Myosin抑制剂 Myosin激活剂 Myosin调节剂

PAK

PAK抑制剂 PAK激活剂 PAK其他

ROCK

ROCK抑制剂 ROCK激活剂

Annexin A
Epigenetics

Histone Modification

Aurora Kinase Glycosyltransferase HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase JAK Methionine Adenosyltransferase (MAT) PARP PKC Protein Arginine Deiminase Sirtuin WDR5

DNA Methylation

AMPK DNA Methyltransferase METTL3 TET Protein

Epigenetic Reader Domain

Epigenetic Reader Domain YTHDF

Non-coding RNA

MicroRNA SF3B1
GPCR/G Protein

Class A GPCR

5-HT Receptor Adenosine Receptor Adrenergic Receptor Angiotensin Receptor Apelin Receptor (APJ) Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CCR Cholecystokinin Receptor CXCR Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) Free Fatty Acid Receptor G protein-coupled Bile Acid Receptor 1 GHSR GNRH Receptor GPR4 GPR27 GPR35 GPR52 GPR55 GPR68 GPR81 GPR84 GPR88 GPR109A GPR119 GPR139 GPR171 Histamine Receptor Imidazoline Receptor Kisspeptin Receptor Leukotriene Receptor LPL Receptor mAChR Mas-related G-protein-coupled Receptor (MRGPR) MCHR1 (GPR24) Melanocortin Receptor Melatonin Receptor Motilin Receptor Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor Platelet-activating Factor Receptor (PAFR) Prostaglandin Receptor Protease Activated Receptor (PAR) RXFP Receptor Somatostatin Receptor Succinate Receptor 1 Trace Amine-associated Receptor (TAAR) TSH Receptor Urotensin Receptor Vasopressin Receptor

Class B GPCR

CGRP Receptor CRFR GLP Receptor Glucagon Receptor PACAP Receptor Secretin Receptor

Class C GPCR

CaSR mGluR Taste Receptor

G Protein Related

Adenylate Cyclase (AC) Arrestin G Protein-coupled Receptor Kinase (GRK) Guanylate Cyclase PKG Ras RGS Protein
Immunology/Inflammation

Arginase

Aryl Hydrocarbon Receptor (AhR)

Aryl Hydrocarbon Receptor (AhR)拮抗剂 Aryl Hydrocarbon Receptor (AhR)激动剂 Aryl Hydrocarbon Receptor (AhR)激活剂 Aryl Hydrocarbon Receptor (AhR)调节剂 Aryl Hydrocarbon Receptor (AhR)抑制剂 Aryl Hydrocarbon Receptor (AhR)其他 Aryl Hydrocarbon Receptor (AhR)诱导剂

CCR

CCR拮抗剂 CCR抑制剂 CCR激动剂 CCR其他

Complement System

COX

COX抑制剂 COX激活剂 COX拮抗剂 COX调节剂 COX其他

CXCR

CXCR拮抗剂 CXCR抑制剂 CXCR激动剂 CXCR调节剂 CXCR其他

Cyclic GMP-AMP Synthase (cGAS)

TIM-3

TIGIT

CTLA-4

FKBP

FLAP

Galectin

IFNAR

Interleukin Related

Interleukin Related抑制剂 Interleukin Related调节剂 Interleukin Related拮抗剂 Interleukin Related诱导剂 Interleukin Related激活剂 Interleukin Related激动剂 Interleukin Related其他

IRAK

MIF

MyD88

NO Synthase

NO Synthase抑制剂 NO Synthase激活剂 NO Synthase激动剂 NO Synthase调节剂 NO Synthase其他

NOD-like Receptor (NLR)

NOD-like Receptor (NLR)抑制剂 NOD-like Receptor (NLR)激活剂 NOD-like Receptor (NLR)激动剂 NOD-like Receptor (NLR)拮抗剂 NOD-like Receptor (NLR)其他

PD-1/PD-L1

PGE synthase

CX3CR1

Pyroptosis

Pyroptosis抑制剂 Pyroptosis激活剂 Pyroptosis诱导剂 Pyroptosis其他

Nuclear Factor of activated T Cells (NFAT)

Reactive Oxygen Species

Reactive Oxygen Species抑制剂 Reactive Oxygen Species激活剂 Reactive Oxygen Species诱导剂 Reactive Oxygen Species激动剂 Reactive Oxygen Species调节剂 Reactive Oxygen Species其他

AP-1

Salt-inducible Kinase (SIK)

SOD

SPHK

STING

STING激动剂 STING激活剂 STING抑制剂 STING拮抗剂 STING其他 STING降解剂

Thrombopoietin Receptor

Toll-like Receptor (TLR)

Toll-like Receptor (TLR)抑制剂 Toll-like Receptor (TLR)激动剂 Toll-like Receptor (TLR)拮抗剂 Toll-like Receptor (TLR)调节剂 Toll-like Receptor (TLR)激活剂 Toll-like Receptor (TLR)其他

PSMA

Glucocorticoid Receptor (GR)

Glucocorticoid Receptor (GR)激动剂 Glucocorticoid Receptor (GR)调节剂 Glucocorticoid Receptor (GR)抑制剂 Glucocorticoid Receptor (GR)激活剂 Glucocorticoid Receptor (GR)拮抗剂 Glucocorticoid Receptor (GR)其他

FAP

Histamine Receptor

Histamine Receptor拮抗剂 Histamine Receptor抑制剂 Histamine Receptor激动剂 Histamine Receptor调节剂 Histamine Receptor激活剂 Histamine Receptor其他

Macrophage migration inhibitory factor (MIF)

LAG-3

Mucin

Mesothelin

Nectin-4

P-selectin

TROP2

DPEP3

BCMA

MUC16

BAFF

CD markers

FcRn

CSF2

IgE

Glycoprotein VI

Kallikrein

CD47

CD47抑制剂

BCL6
JAK/STAT Signaling

EGFR

EGFR抑制剂 EGFR激活剂 EGFR拮抗剂 EGFR其他 EGFR降解剂 EGFR激动剂

HER2

HER3

HER4

JAK

JAK抑制剂 JAK激活剂 JAK其他

Pim

STAT

STAT抑制剂 STAT激活剂 STAT激动剂 STAT拮抗剂 STAT降解剂 STAT其他

MUC16
MAPK Signaling Pathway

ERK

ERK抑制剂 ERK激活剂 ERK激动剂 ERK调节剂 ERK诱导剂 ERK化学品 ERK其他

JNK

JNK抑制剂 JNK激活剂 JNK其他

KLF

MAP3K

MAP4K

MAP4K抑制剂

MEK

MEK抑制剂 MEK拮抗剂 MEK激活剂 MEK其他

Mixed Lineage Kinase

MNK

p38 MAPK

p38 MAPK抑制剂 p38 MAPK激活剂 p38 MAPK诱导剂 p38 MAPK调节剂 p38 MAPK激动剂 p38 MAPK其他

Raf

Ribosomal S6 Kinase (RSK)

MAPKAPK2 (MK2)

Macrophage migration inhibitory factor (MIF)

BCMA
Membrane Transporter/Ion Channel

Membrane Transporter

Anion Exchangers Apical Sodium-Dependent Bile Acid Transporter Amino acid Transporter ASCT ATP Synthase BCRP Calmodulin CFTR CRM1 EAAT FATP Ferroportin GLUT GlyT Monoamine Transporter (MAT) Monocarboxylate Transporter (MCT) Na+/Ca2+ Exchanger Na+/H+ Exchanger (NHE) Na+/HCO3- Cotransporter Na+/K+ ATPase NKCC Nucleoside Transporter Organic anion transporter (OAT) P-glycoprotein Proton Pump SGLT URAT1 VDAC

Ion Channel

Aquaporin (AQP) Chloride Channel CRAC Channel HCN Channel Mechanosensitive channels (MSCs) P2X Receptor VDAC Calmodulin Piezo Channel nAChR Potassium Channel Sodium Channel Calcium Channel GABA Receptor iGluR TRP Channel
Metabolism

Glucose Metabolism

Aldose Reductase Carbonic Anhydrase Enolase FBPase Glucokinase Glucosidase Glutathione Peroxidase Glyoxalase (GLO) Hexokinase HIF/HIF Prolyl-Hydroxylase Lactate Dehydrogenase (LDH) Mineralocorticoid Receptor (MR) Phosphoglycerate Dehydrogenase (PHGDH) PEPCK Pyruvate Kinase SGK Glucose-6-phosphate dehydrogenase (G6PD) NAMPT Mitochondrial Metabolism NADPH Oxidase PGC-1α Phosphatase Reactive Oxygen Species Amylases PFKFB3 Sialyltransferase UGT Ketohexokinase Oxidative Phosphorylation

Lipid Metabolism

11β-HSD 15-PGDH 17β-HSD 5α-reductase Acetyl-CoA carboxylase Acyltransferase Adiponectin Receptor Aldehyde Dehydrogenase (ALDH) ATGL ATP Citrate Lyase Ceramidase CETP Cytochrome P450 DGK Epoxide Hydrolase FAAH FABP Fat Mass and Obesity-associated Protein (FTO) Fatty Acid Synthase (FASN) Farnesoid X Receptor (FXR) HMG-CoA Reductase (HMGCR) Isocitrate Dehydrogenase (IDH) LDLR Liposome Liver X Receptor (LXR) MAGL Microsomal Triglyceride Transfer Protein (MTP) PDHK Stearoyl-CoA Desaturase (SCD) ROR REV-ERB RAR/RXR Phospholipase Lipoxygenase Mitochondrial Metabolism NADPH Oxidase PGC-1α Phosphatase Reactive Oxygen Species PI5P4K ELOVL Lysosomal acid lipase (LAL) Steroid Sulfatase PCSK9 Lipase Carboxylesterase

Amino Acid/Protein Metabolism

Acetolactate Synthase (ALS) Adenosine Deaminase Adenosine Kinase Carboxypeptidase GSNOR MALT1 Methionine Adenosyltransferase (MAT) Furin HCV Protease HIV Protease HPPD Aminopeptidase Angiotensin-converting Enzyme (ACE) Arginase Cathepsin COMT Dipeptidyl Peptidase Dopamine β-hydroxylase Elastase Factor Xa Farnesyl Transferase (FTase) Glutaminase Glutathione S-transferase HSP Indoleamine 2,3-Dioxygenase (IDO) MMP NEDD8-activating Enzyme Neprilysin PAI-1 PDI Procollagen C Proteinase Prolyl Endopeptidase (PREP) Renin Thrombin Tryptophan Hydroxylase Tyrosinase Xanthine Oxidase Ser/Thr Protease Methylenetetrahydrofolate Dehydrogenase (MTHFD) Mitochondrial Metabolism NADPH Oxidase Phosphatase Reactive Oxygen Species MetAP ADAMTS Legumain Factor VIII

Nucleic Acid Metabolism

Aminoacyl-tRNA Synthetase Cryptochrome Dihydrofolate reductase (DHFR) Dihydroorotate Dehydrogenase (DHODH) HIV Integrase Phosphodiesterase (PDE) Methylenetetrahydrofolate Dehydrogenase (MTHFD) NAMPT OGG1 IMPDH

Drug Metabolite

Drug Metabolite抑制剂 Drug Metabolite调节剂 Drug Metabolite其他 Drug Metabolite化学品

Vitamin

Vitamin A Vitamin B Vitamin C Vitamin D/VDR Vitamin E1 Vitamin K

Endogenous Metabolite

Endogenous Metabolite抑制剂 Endogenous Metabolite调节剂 Endogenous Metabolite诱导剂 Endogenous Metabolite拮抗剂 Endogenous Metabolite其他
Neuronal Signaling

5-HT Receptor

5-HT Receptor拮抗剂 5-HT Receptor激动剂 5-HT Receptor抑制剂 5-HT Receptor调节剂 5-HT Receptor激活剂 5-HT Receptor其他

Cholinesterase (ChE)

Cholinesterase (ChE)抑制剂 Cholinesterase (ChE)激活剂 Cholinesterase (ChE)拮抗剂 Cholinesterase (ChE)其他

Adenosine Kinase

Adrenergic Receptor

Adrenergic Receptor激动剂 Adrenergic Receptor拮抗剂 Adrenergic Receptor抑制剂 Adrenergic Receptor激活剂 Adrenergic Receptor调节剂 Adrenergic Receptor其他

Calcium Channel

Calcium Channel抑制剂 Calcium Channel拮抗剂 Calcium Channel激活剂 Calcium Channel激动剂 Calcium Channel其他 Calcium Channel调节剂

CaMK

CaMK抑制剂 CaMK激活剂 CaMK拮抗剂 CaMK其他

Cannabinoid Receptor

Cannabinoid Receptor拮抗剂 Cannabinoid Receptor激动剂 Cannabinoid Receptor抑制剂 Cannabinoid Receptor调节剂 Cannabinoid Receptor激活剂 Cannabinoid Receptor其他

CGRP Receptor

Cholecystokinin Receptor

COMT

iGluR

iGluR拮抗剂 iGluR抑制剂 iGluR激动剂 iGluR调节剂 iGluR激活剂 iGluR其他

Dopamine Receptor

Dopamine Receptor拮抗剂 Dopamine Receptor激动剂 Dopamine Receptor抑制剂 Dopamine Receptor调节剂 Dopamine Receptor激活剂 Dopamine Receptor其他

Tau Protein

Dopamine Transporter

FAAH

GABA Receptor

GABA Receptor激动剂 GABA Receptor拮抗剂 GABA Receptor抑制剂 GABA Receptor激活剂 GABA Receptor调节剂 GABA Receptor其他

GlyT

GPR119

GPR139

GPR55

Imidazoline Receptor

mAChR

mAChR拮抗剂 mAChR激动剂 mAChR抑制剂 mAChR调节剂 mAChR激活剂 mAChR诱导剂 mAChR其他

Melanocortin Receptor

Melatonin Receptor

mGluR

mGluR激动剂 mGluR拮抗剂 mGluR抑制剂 mGluR调节剂 mGluR激活剂 mGluR其他

Monoamine Oxidase

nAChR

nAChR激动剂 nAChR抑制剂 nAChR拮抗剂 nAChR调节剂 nAChR激活剂 nAChR其他

Neurokinin Receptor

Neurokinin Receptor拮抗剂 Neurokinin Receptor抑制剂 Neurokinin Receptor调节剂 Neurokinin Receptor激动剂 Neurokinin Receptor其他

Neuropeptide Y Receptor

Neurotensin Receptor

Opioid Receptor

Opioid Receptor激动剂 Opioid Receptor拮抗剂 Opioid Receptor抑制剂 Opioid Receptor激活剂 Opioid Receptor其他 Opioid Receptor调节剂

Orexin Receptor (OX Receptor)

Transthyretin (TTR)

Glucosylceramide Synthase (GCS)

α-synuclein

AAK1

Serotonin Transporter

Serotonin Transporter抑制剂 Serotonin Transporter拮抗剂 Serotonin Transporter激活剂 Serotonin Transporter调节剂

MCHR1 (GPR24)

Sigma Receptor

Sigma Receptor激动剂 Sigma Receptor拮抗剂 Sigma Receptor抑制剂 Sigma Receptor其他

Somatostatin Receptor

TRK

TRK抑制剂 TRK激动剂 TRK激活剂 TRK拮抗剂 TRK其他

TRP Channel

TRP Channel抑制剂 TRP Channel拮抗剂 TRP Channel激动剂 TRP Channel激活剂 TRP Channel调节剂 TRP Channel其他

β-Amyloid

β-Amyloid抑制剂 β-Amyloid激动剂 β-Amyloid拮抗剂 β-Amyloid其他 β-Amyloid化学品

β-secretase

γ-secretase

γ-secretase抑制剂 γ-secretase调节剂 γ-secretase其他

Histamine Receptor

Histamine Receptor拮抗剂 Histamine Receptor抑制剂 Histamine Receptor激动剂 Histamine Receptor调节剂 Histamine Receptor激活剂 Histamine Receptor其他

Notch

Notch抑制剂 Notch激活剂 Notch激动剂 Notch调节剂 Notch其他

PINK1/Parkin

OGT

OGA
NF-κB Signaling

RANKL/RANK

RANKL/RANK抑制剂 RANKL/RANK其他

IKK

IKK抑制剂 IKK其他

Keap1-Nrf2

MALT1

MALT1抑制剂

NF-κB

NF-κB抑制剂 NF-κB激活剂 NF-κB调节剂 NF-κB激动剂 NF-κB降解剂 NF-κB其他

Reactive Oxygen Species

Reactive Oxygen Species抑制剂 Reactive Oxygen Species激活剂 Reactive Oxygen Species诱导剂 Reactive Oxygen Species激动剂 Reactive Oxygen Species调节剂 Reactive Oxygen Species其他

BCMA
Nuclear Receptor Signaling

Thyroid Hormone Receptor (THR)

Thyroid Hormone Receptor (THR)激动剂 Thyroid Hormone Receptor (THR)激活剂 Thyroid Hormone Receptor (THR)拮抗剂 Thyroid Hormone Receptor (THR)抑制剂 Thyroid Hormone Receptor (THR)调节剂 Thyroid Hormone Receptor (THR)其他

Androgen Receptor (AR)

Androgen Receptor (AR)拮抗剂 Androgen Receptor (AR)抑制剂 Androgen Receptor (AR)调节剂 Androgen Receptor (AR)激动剂 Androgen Receptor (AR)降解剂 Androgen Receptor (AR)其他

Estrogen Receptor (ER)/ERR

Estrogen Receptor (ER)/ERR调节剂 Estrogen Receptor (ER)/ERR拮抗剂 Estrogen Receptor (ER)/ERR抑制剂 Estrogen Receptor (ER)/ERR激动剂 Estrogen Receptor (ER)/ERR激活剂 Estrogen Receptor (ER)/ERR降解剂 Estrogen Receptor (ER)/ERR其他

Glucocorticoid Receptor (GR)

Glucocorticoid Receptor (GR)激动剂 Glucocorticoid Receptor (GR)调节剂 Glucocorticoid Receptor (GR)抑制剂 Glucocorticoid Receptor (GR)激活剂 Glucocorticoid Receptor (GR)拮抗剂 Glucocorticoid Receptor (GR)其他

Mineralocorticoid Receptor (MR)

Progesterone Receptor (PR)

Progesterone Receptor (PR)激动剂 Progesterone Receptor (PR)拮抗剂 Progesterone Receptor (PR)激活剂 Progesterone Receptor (PR)抑制剂 Progesterone Receptor (PR)调节剂 Progesterone Receptor (PR)其他

RAR/RXR

RAR/RXR激动剂 RAR/RXR抑制剂 RAR/RXR拮抗剂 RAR/RXR调节剂 RAR/RXR激活剂

PPAR

PPAR激动剂 PPAR激活剂 PPAR抑制剂 PPAR拮抗剂 PPAR调节剂 PPAR其他

ROR

ROR拮抗剂 ROR抑制剂 ROR激动剂 ROR调节剂 ROR其他

Liver X Receptor (LXR)

Liver X Receptor (LXR)激动剂 Liver X Receptor (LXR)拮抗剂 Liver X Receptor (LXR)激活剂 Liver X Receptor (LXR)抑制剂 Liver X Receptor (LXR)调节剂 Liver X Receptor (LXR)其他

Pregnane X receptor (PXR)

Nur77

NURR1

REV-ERB

Constitutive androstane receptor (CAR)

Vitamin D/VDR

Vitamin D/VDR激活剂 Vitamin D/VDR激动剂 Vitamin D/VDR调节剂 Vitamin D/VDR化学品 Vitamin D/VDR其他

COUP-TF

HNF4α

Steroidogenic Factor 1 (SF1)

Liver receptor Homolog-1 (LRH-1)

Farnesoid X Receptor (FXR)

Farnesoid X Receptor (FXR)激动剂 Farnesoid X Receptor (FXR)拮抗剂 Farnesoid X Receptor (FXR)激活剂 Farnesoid X Receptor (FXR)抑制剂 Farnesoid X Receptor (FXR)调节剂

TSH Receptor
PI3K/Akt/mTOR

Akt

Akt抑制剂 Akt激活剂 Akt调节剂 Akt诱导剂 Akt其他

AMPK

AMPK激活剂 AMPK抑制剂 AMPK诱导剂 AMPK激动剂 AMPK其他

ATM/ATR

ATM/ATR抑制剂 ATM/ATR激活剂 ATM/ATR其他

DNA-PK

GSK-3

GSK-3抑制剂 GSK-3激活剂 GSK-3其他

MELK

mTOR

mTOR抑制剂 mTOR激活剂 mTOR拮抗剂 mTOR调节剂 mTOR其他

PDK-1

PI3K

PI3K抑制剂 PI3K激活剂 PI3K调节剂 PI3K激动剂 PI3K其他

PI4K

PIKfyve

PTEN

PTEN抑制剂 PTEN激活剂 PTEN其他

PDPK1

PIN1

TROP2

LYPD3

FOXO
Protein Tyrosine Kinase/RTK

Receptor Tyrosine Kinase

Anaplastic lymphoma kinase (ALK) c-Fms c-Kit c-Met/HGFR Discoidin Domain Receptor Ephrin Receptor FGFR FLT3 IGF-1R Insulin Receptor PDGFR RET ROS Kinase TAM Receptor VEGFR Tie EGFR TRK HER2 HER3 HER4

Non-receptor Tyrosine Kinase

Ack1 Bcr-Abl BMX Kinase BTK DYRK FAK ITK Pyk2 SHP2 Src Syk JAK
Stem Cell/Wnt

Casein Kinase

Casein Kinase抑制剂 Casein Kinase激活剂 Casein Kinase降解剂 Casein Kinase其他

ERK

ERK抑制剂 ERK激活剂 ERK激动剂 ERK调节剂 ERK诱导剂 ERK化学品 ERK其他

γ-secretase

γ-secretase抑制剂 γ-secretase调节剂 γ-secretase其他

Gli

Gli抑制剂 Gli拮抗剂

GSK-3

GSK-3抑制剂 GSK-3激活剂 GSK-3其他

Hedgehog

Hedgehog抑制剂 Hedgehog拮抗剂 Hedgehog调节剂 Hedgehog激动剂 Hedgehog激活剂

Hippo (MST)

Hippo (MST)抑制剂 Hippo (MST)其他

MAP4K

MAP4K抑制剂

NEDD8-activating Enzyme

NEDD8-activating Enzyme抑制剂

Notch

Notch抑制剂 Notch激活剂 Notch激动剂 Notch调节剂 Notch其他

Oct3/4

PKA

PKA抑制剂 PKA激活剂 PKA拮抗剂 PKA调节剂 PKA激动剂 PKA其他

Porcupine

Porcupine抑制剂

ROCK

ROCK抑制剂 ROCK激活剂

sFRP-1

sFRP-1抑制剂

Smo

Smo拮抗剂 Smo抑制剂 Smo激动剂 Smo激活剂 Smo调节剂

TGF-β/Smad

TGF-β/Smad抑制剂 TGF-β/Smad激活剂 TGF-β/Smad激动剂 TGF-β/Smad调节剂 TGF-β/Smad其他

JAK

JAK抑制剂 JAK激活剂 JAK其他

Wnt/β-catenin

Wnt/β-catenin抑制剂 Wnt/β-catenin激活剂 Wnt/β-catenin激动剂 Wnt/β-catenin拮抗剂 Wnt/β-catenin调节剂 Wnt/β-catenin降解剂 Wnt/β-catenin其他 TBL1X (TBL1)

YAP-TEAD

YAP-TEAD抑制剂 YAP-TEAD拮抗剂 YAP-TEAD调节剂 YAP-TEAD激活剂 YAP-TEAD其他

STAT

STAT抑制剂 STAT激活剂 STAT激动剂 STAT拮抗剂 STAT降解剂 STAT其他

TROP2

ROR2

MUC16

Sclerostin (SOST)

PTK7

Organoid

RUNX

RUNX抑制剂 RUNX激活剂
TGF-beta/Smad

PKC

PKC抑制剂 PKC拮抗剂 PKC激活剂 PKC调节剂 PKC激动剂 PKC其他

ROCK

ROCK抑制剂 ROCK激活剂

TGF-β Receptor

TGF-β Receptor抑制剂 TGF-β Receptor拮抗剂 TGF-β Receptor激动剂 TGF-β Receptor激活剂 TGF-β Receptor其他

TGF-β/Smad

TGF-β/Smad抑制剂 TGF-β/Smad激活剂 TGF-β/Smad激动剂 TGF-β/Smad调节剂 TGF-β/Smad其他

PKA

PKA抑制剂 PKA激活剂 PKA拮抗剂 PKA调节剂 PKA激动剂 PKA其他

RUNX

RUNX抑制剂 RUNX激活剂

Dan family
Ubiquitin/Proteasome

Deubiquitinase

E1 Activating

E1 Activating抑制剂 E1 Activating激活剂

E2 conjugating

E2 conjugating抑制剂 E2 conjugating其他

E3 ligase

E3 ligase抑制剂 E3 ligase激动剂 E3 ligase其他

p97

p97抑制剂 p97其他

Proteasome

Proteasome抑制剂 Proteasome激活剂 Proteasome调节剂 Proteasome其他
Others

Others

Amino Acid Derivatives

Herbicide

Gli抑制剂

Gli抑制剂相关产品（2）

货号	产品名	中文名称	产品描述
SJ-MX0482	GANT61		GANT61 (NSC 136476) 是靶向 Hedgehog/GLi 通路的 Gli1 和 Gli2 抑制剂。GANT61 在 LX-2 细胞中可诱导凋亡 (apoptosis) 并激活保护性自噬 (autophagy)。
SJ-MX1272	Glabrescione B		Glabrescione B 是第一个结合 Hedgehog (Hh) 调节剂 Gli1 并通过干扰 Gli1-DNA 相互作用而削弱其活性的化合物。Glabrescione B 抑制 Hedgehog 依赖性肿瘤细胞的生长，抑制肿瘤源性干细胞的自我更新能力和克隆能力。

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