货号 | 产品名 | 中文名称 | 产品描述 |
---|---|---|---|
SJ-MX2111 | Cinacalcet (AMG 073) hydrochloride | 盐酸甲状旁腺激素 | Cinacalcet hydrochloride (AMG 073 hydrochloride) 是一种可口服的 Ca receptor (CaR) 激动剂,用于心血管疾病研究。 |
SJ-MX4207 | SB-423562 | SB-423562 是一种短效的 (CaR) 拮抗剂。SB-423562 具有用于研究骨质疏松症的潜力。 | |
SJ-MX2112 | NPS-2143 (SB-262470A) | NPS-2143 (SB-262470A),口服活性溶钙剂, 是选择性的钙敏感受体 (CaSR) 拮抗剂。NPS-2143 (SB-262470A) 通过激活表达人 Ca2+ 受体的 HEK 293 细胞中的 Ca2+ 受体而引起的胞浆 Ca2+ 浓度增加 (IC50=43 nM)。 | |
SJ-BP0202 | Etelcalcetide | Etelcalcetide (formerly known as AMG-416, KAI-4169; ONO5163; velcalcetide, trade name Parsabiv) is a calcimimetic drug for the treatment of secondary hyperparathyroidism in chronic kidney disease (CKD) patients undergoing hemodialysis. It is administered intravenously at the end of each dialysis session. Etelcalcetide functions by binding to and activating the calcium-sensing receptor in the parathyroid gland. | |
SJ-MN1298 | Ligustroflavone | 女贞苷 | Ligustroflavone 可从Ligustrum lucidum 中提取得到,是一种潜在的钙敏感受体(CaSR) 拮抗剂。Ligustroflavone对糖尿病性骨质疏松症小鼠有保护作用。 |
SJ-MX2112A | NPS-2143 hydrochloride | NPS-2143 hydrochloride (also known as SB-262470 and SB-262470A) is a novel, potent and selective antagonist of calcium-sensing receptor (CaSR) with IC50 of 43 nM. NPS-2143 stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents. | |
SJ-MX2344 | Cinacalcet | 西那卡塞 | Cinacalcet (also known as AMG-073; trade names Sensipar, Mimpara) is a calcimimetic that mimics the action of calcium on tissues by allosteric activation of the calcium-sensing receptor expressed in various human organ tissues. It is a novel class of compounds for the treatment of hyperparathyroidism. Cinacalcet is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR. In the presence of calcium ions, it can inhibit parathyroid hormone secretion by activating CaSR in parathyroid glands. |
SJ-MX5413 | Gadolinium chloride | ||
SJ-MX2717 | Strontium Ranelate | 雷尼酸锶 |
Strontium Ranelate (S12911)是一种抗骨质疏松药物,其作用是通过减少骨吸收并促进骨形成,从而诱导正骨平衡。Strontium Ranelate 还可以激活非骨骼细胞中的钙敏感受体 (CaSR),从而导致肌醇 1、4、5-三磷酸生成和丝裂原活化的蛋白激酶信号转导。 |