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TOPK

TOPK相关产品(6)
货号 产品名 中文名称 产品描述
SJ-MX2040 Ilaprazole (IY-81149) 艾普拉唑 Ilaprazole (IY-81149),一种具有口服活性质子泵抑制剂,以剂量依赖性方式不可逆地抑制 H+/K+-ATPase,在兔壁细胞制剂中的 IC50 为 6 μM。Ilaprazole 用于胃溃疡的研究。Ilaprazole 也是一种有效的T细胞起源蛋白激酶 (TOPK) 抑制剂。
SJ-MX1764 OTS964 hydrochloride OTS964 hydrochloride 是一种口服有效的,高亲和力和选择性的 TOPK (T 淋巴因子激活的杀伤细胞起源的蛋白激酶) 抑制剂,IC50 为 28 nM。OTS964 也是一种有效的细胞周期蛋白依赖激酶 CDK11 抑制剂,结合 CDK11B 的 Kd 值为 40 nM。OTS964 处理可激活胶质瘤细胞中的自噬,并诱导小鼠异种移植物中人肺癌细胞的凋亡。
SJ-MX3518 OTS514 OTS514 (OTS-514) is a novel TOPK (T-LAK cell-originated protein kinase) inhibitor with potential anticancer activity. It inhibits TOPK with an IC50 of 2.6 nM. It strongly suppressed the growth of TOPK-positive cancer cells. It also shows significant growth-inhibitory effect on ovarian cancer cell lines with IC50 values of 3.0 to 46 nM. OTS514 displays growth inhibitory effects against small cell lung cancer with IC50 in the range of 0.4 ~ 42.6 nM and can lead to their apoptotic cell death. OTS514 also suppressed forkhead box protein M1 (FOXM1) activity, a protein involved in stemness of CSC. Furthermore, treatment with OTS514 reduced CD90-positive SCLC cells and exhibited higher cytotoxicity against lung sphere-derived CSC-like SCLC cells.
SJ-MA0389 Cephradine 头孢拉定 Cefradin is a semi-synthetic cephalosporin antibiotic. Cefradin inhibits the last stage of bacterial cell wall synthesis by binding to certain penicillin-binding proteins which results in cell lysis. Cell lysis is mediated by bacterial cell wall autolytic enzymes. Cefradin may interfere with autolysin inhibitors.
SJ-MA0454 Cephradine monohydrate 头孢拉定一水合物 Cefradine is a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity.
SJ-MX1674 HI-TOPK-032 HI-TOPK-032是有效特异的TOPK抑制剂。