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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MX2947 | BAY 41-2272 | BAY 41-2272 is a novel and potent activator of nitric oxide-sensitive guanylyl cyclase (NO-sensitive GC) with EC50 values of 0.3 μmol/L and 3 μmol/L in the presence and absence of 100 nmol/L DEA-NO, respectively. In platelets, GSNO at 3 μmol/L (a submaximally effective concentration) was used to assess a possible sensitizing effect of BAY 41-2272 on NO-sensitive GC. The cGMP response resulted from the application of NO at this concentration in the absence of BAY 41-2272 was only marginal. In the presence of BAY 41-2272 at 100 μmol/L, treatment with GSNO at 3 μmol/L resulted in a rapid increase in cGMP up to 1000 pmol/109 platelets. | |
| SJ-MX1605 | Vericiguat | 维利西呱 |
Vericiguat 是一种有效的口服可溶性鸟苷酸环化酶（sGC）的刺激物。 |
| SJ-MX2128 | Riociguat (BAY 632521) | 利奥西呱 | Riociguat (BAY 632521) 是一种可口服的可溶性鸟苷酸环化酶 (sGC) 刺激剂，常用于研究肺动脉高压症。 |
| SJ-MX4659 | NS-2028 | NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). It blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 are 17 and 20 nM respectively). NS 2028 also inhibits VEGF-induced cGMP accumulation. | |
| SJ-MX0346 | Lificiguat (YC-1) | 利非西呱 |
Lificiguat (YC-1)是一种不依赖于NO的可溶性鸟苷酸环化酶（soluble guanylyl cyclase，sGC)激活剂，在CO存在条件下，Kd 为 0.6-1.1 μM。Lificiguat (YC-1)是Hypoxia-inducible factor-1alpha (HIF-1α)抑制剂。 |
| SJ-MD0017 | Methylene Blue | 亚甲兰 | Methylene Blue (Basic Blue 9， Tetramethylthionine chloride， methylthioninium chloride， CI-52015)在色素内镜检查中被作用染料。它能抑制tau蛋白丝的形成，IC50为1.9μM，同时还抑制可溶性鸟苷环化酶。 |
| SJ-BP0094 | Plecanatide | 普卡那肽 | Plecanatide是尿鸟苷蛋白的类似物，是一种具有口服活性的鸟苷酸环化酶C受体(guanylate cyclase-C (GC-C) receptor)激动剂，在T84细胞实验中激活GC-C受体以刺激cGMP合成的EC50值为190 nM。Plecanatide在小鼠结肠炎模型中具有抗炎活性。 |
| SJ-MX5406 | Ataciguat | ||
| SJ-MX5505 | Cinaciguat | ||
| SJ-MD0017A | Methylene blue trihydrate | 亚甲蓝三水合物 | |
| SJ-MX5418 | ODQ |
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