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Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog Nur77 p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Endocrinology/Hormones

Adrenergic Receptor Androgen Receptor Angiotensin-converting Enzyme (ACE) Aromatase Cholecystokinin Receptor TSH Receptor Estrogen Receptor/ERR GHSR Glucocorticoid Receptor GNRH Receptor Mineralocorticoid Receptor Opioid Receptor PGD synthase PGE synthase Progesterone Receptor Thyroid Hormone Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor E3 Ligase Ligand-Linker Conjugates RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Mas-related G-protein-coupled Receptor (MRGPR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 Protease Activated Receptor (PAR) Vasopressin Receptor

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Guanylate Cyclase

Guanylate Cyclase相关产品（12）

货号	产品名	中文名称	产品描述
SJ-BP0094	Plecanatide	普卡那肽	Plecanatide是尿鸟苷蛋白的类似物，是一种具有口服活性的鸟苷酸环化酶C受体(guanylate cyclase-C (GC-C) receptor)激动剂，在T84细胞实验中激活GC-C受体以刺激cGMP合成的EC50值为190 nM。Plecanatide在小鼠结肠炎模型中具有抗炎活性。
SJ-MX5406	Ataciguat		Ataciguat (HMR-1766) 是一种不依赖一氧化氮的可溶性鸟苷酸环化酶 (sGC) 激活剂。Ataciguat 能够激活 sGC 的铁血红素铁氧化还原形式，刺激 cGMP 的产生。Ataciguat 具有血管舒张作用。
SJ-MX5418	ODQ		ODQ 是一种有效的选择性可溶性鸟苷酰环化酶 (sGC) 抑制剂。ODQ 增强顺铂促人间皮瘤细胞凋亡的作用。
SJ-MX5505	Cinaciguat		Cinaciguat hydrochloride是一种不依赖于一氧化氮的鸟苷酸环化酶 (GC) 活化剂，Kd 值为3.2 nM。
SJ-MX4659	NS-2028		NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). It blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 are 17 and 20 nM respectively). NS 2028 also inhibits VEGF-induced cGMP accumulation.
SJ-BP0092A	Linaclotide	利那洛肽
SJ-MX2947	BAY 41-2272		BAY 41-2272是一种新型高效的一氧化氮敏感官能环化酶(no敏感GC)活化剂，在DEA-NO存在和不存在时，EC50值分别为0.3 μmol/L和3 μmol/L。
SJ-MD0017A	Methylene blue trihydrate	亚甲蓝三水合物	Methylene blue trihydrate 是一种鸟苷酸环化酶 (sGC)，单胺氧化酶 A (MAO-A) 和 NO 合酶 (NOS) 抑制剂。Methylene blue trihydrate 是一种血管加压药，在医疗中通常用作染料。Methylene blue trihydrate 具有抗伤害感受，抗疟疾，抗抑郁和抗焦虑作用，可用于高铁血红蛋白血症，神经退行性疾病和异环磷酰胺引起的脑病的研究。
SJ-MX0346	Lificiguat (YC-1)	利非西呱	Lificiguat (YC-1)是一种不依赖于NO的可溶性鸟苷酸环化酶（soluble guanylyl cyclase，sGC)激活剂，在CO存在条件下，Kd 为 0.6-1.1 μM。Lificiguat (YC-1)是Hypoxia-inducible factor-1alpha (HIF-1α)抑制剂。
SJ-MX1605	Vericiguat	维利西呱	Vericiguat 是一种有效的口服可溶性鸟苷酸环化酶（sGC）的刺激物。
SJ-MX2128	Riociguat (BAY 632521)	利奥西呱	Riociguat (BAY 632521) 是一种可口服的可溶性鸟苷酸环化酶 (sGC) 刺激剂，常用于研究肺动脉高压症。
SJ-MD0017	Methylene Blue	亚甲兰	Methylene Blue (Basic Blue 9; Tetramethylthionine chloride; methylthioninium chloride; CI-52015) 在色素内镜检查中被作用染料。它能抑制 tau 蛋白丝的形成，IC50 为 1.9 μM，同时还抑制可溶性鸟苷环化酶。