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Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease
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Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog Nur77 p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Endocrinology/Hormones

Adrenergic Receptor Androgen Receptor Angiotensin-converting Enzyme (ACE) Aromatase Cholecystokinin Receptor TSH Receptor Estrogen Receptor/ERR GHSR Glucocorticoid Receptor GNRH Receptor Mineralocorticoid Receptor Opioid Receptor PGD synthase PGE synthase Progesterone Receptor Thyroid Hormone Receptor
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AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor E3 Ligase Ligand-Linker Conjugates RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Mas-related G-protein-coupled Receptor (MRGPR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 Protease Activated Receptor (PAR) Vasopressin Receptor

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SUMO

类泛素蛋白修饰分子

SUMO化修饰是一种普遍存在、动态可逆的蛋白翻译后修饰类型，在高等真核细胞中，至少存在三种SUMO蛋白（SUMO1/2/3）和六种SUMO特异性蛋白（Sentrin/SUMO-specific proteases）——SENP1/2/3/5/6/7。SUMO主要分布在细胞核中，其中SUMO1在核膜、核仁、核质都有分布，而SUMO2/3则主要分布于核质。

SUMO化修饰是一个动态可逆的过程，SUMO分子通过在E1活化酶、E2结合酶和E3连接酶的参与下共价结合到底物蛋白赖氨酸残基上，调控底物蛋白的结构与功能，而SENPs则通过特异性地对底物靶蛋白去SUMO化修饰，与SUMO分子共同调节底物蛋白的SUMO化状态，进而调控细胞功能。

SUMO虽然修饰过程与泛素化过程很相似，又称为“小泛素化”，但是SUMO化修饰具有与泛素化修饰截然不同的功能。泛素化修饰的靶分子主要被蛋白酶体降解，而SUMO化修饰介导靶分子定位与功能调节。SUMO化修饰的生物学功能包括：SUMO化修饰能够使蛋白质构象更加稳定，还参与细胞核内的一系列生理过程，如核运输、信号传递、细胞周期调控及基因表达调控等。SUMO化修饰可调节蛋白质之间的相互作用，调节蛋白质核质运输。SUMO化修饰既能协同泛素化，又能拮抗泛素化。SUMO 化修饰还可参与线粒体分裂的调控、基因组完整性的维持、离子通道调控。

SUMO相关产品（3）

货号	产品名	中文名称	产品描述
SJ-MX1025	2-D08		2-D08 (2',3',4'-trihydroxy flavone) 是一种有细胞透性的、小泛素样修饰蛋白 (sumoylation) 抑制剂。2-D08也可抑制 Axl，IC50 为 0.49 nM。
SJ-MX0442	Subasumstat (TAK-981)		Subasumstat (TAK-981) 是首创的、SUMOylation 酶联反应的选择性抑制剂，具有潜在的免疫激活和抗肿瘤活性。
SJ-MN0161	Ginkgolic Acid	银杏酸;白果酸	Ginkgolic Acid 是一种天然化合物，在体外实验中抑制 SUMOylation 的 IC50 为3.0 μM。Ginkgolic Acid 具有抑制肿瘤的功效。