SJ-BP0030
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Ac-FLTD-CMK
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Ac-FLTD-CMK 是胃泌素 D (GSDMD) 衍生的抑制剂,是炎症性 caspases 的特异性抑制剂。Ac-FLTD-CMK 对 caspases-1 (IC50 为 46.7 nM),caspases-4 (IC50 为 1.49 μM),caspases-5 (IC50 为 329 nM) 和 caspases-11 均有效,但对凋亡相关的 caspase-3 无效。
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SJ-MX0643
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Disulfiram
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双硫仑 |
Disulfiram (Tetraethylthiuram disulfide) 是特异性的乙醛脱氢酶 1 型抗体 (ALDH1) 抑制剂,对酒精具有急性敏感性。Disulfiram 有效抑制人体和小鼠细胞中脂质体中的 GSDMD 孔形成,炎性体介导的细胞凋亡和 IL-1β分泌。
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SJ-MN0841
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Polyphyllin VI
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重楼皂苷VI |
Polyphyllin VI, an active saponin mainly extracted from traditional medicinal plant Paris polyphylla, possess anti-cancer activities. Polyphyllin VI induces G2/M cell cycle arrest and triggers apoptosis.
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SJ-MN0852
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Morroniside
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莫诺苷 |
Morroniside 通过抑制神经元凋亡和 MMP9/2 的表达从而发挥神经保护作用。
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SJ-MX4094
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LDC7559
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LDC7559 inhibits the NOX2-dependent oxidative burst in neutrophils by activating the glycolytic enzyme phosphofructokinase-1 liver type (PFKL) and dampening flux through the pentose phosphate pathway. LDC7559 is an inhibitor of NOX2-dependent NETosis with an IC50 value of 3.1 μM.
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