货号 | 产品名 | 中文名称 | 产品描述 |
---|---|---|---|
SJ-MX2821 | Moxonidine | 莫索尼定 | Moxonidine (also known as BDF5895) is a potent and selective agonist at the imidazoline receptor subtype 1, and is used as centrally active antihypertensive agent. Moxonidine can bind to both I1-imidazoline receptor (I1R) and α2-adrenergic receptor (α2AR). The selectivity of moxonidine for I1R is 33-fold over α2AR. Moxonidine plays its antihypertensive role in the central nervous system. It has a central site of action. It is shown no effect in pithed rats and in cats following spinal cord transaction. Moxonidine also reduces sympathetic outflow and lowers peripheral vascular resistence. |
SJ-MX3952 | Agmatine sulfate | 胍基丁胺 | Agmatine sulfate is a neurotransmitter and neuromodulator, inhibiting N-methyl-D-aspartate (NMDA), nicotinic acetylcholine receptors nitric oxide synthase, calcium channels and certain serotonin receptors, activating imidazoline receptors. |
SJ-MX2709 | Rilmenidine phosphate |
Rilmenidine phosphate 是一种新型的抗高血压药物和口服活性选择性 I1 咪唑啉受体 (I1 imidazoline receptor) 激动剂。Rilmenidine phosphate 也是一种 α2 肾上腺素(α2-adrenergic)受体激动剂。Rilmenidine phosphate 诱导自噬 (autophagy)。Rilmenidine phosphate 可通过减少交感神经过度活跃而发挥中枢作用,并通过抑制 Na+/H+ 反向转运而在肾脏中发挥作用。Rilmenidine phosphate 可调节白血病细胞增殖,刺激促凋亡蛋白 Bax,从而诱导人白血病 K562 细胞线粒体通路的紊乱和凋亡。 |