您当前的位置：

信号通路

Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease RABV HPV RABV EBV Dengue Virus β-lactamase Flavivirus VSV Penicillin-binding protein (PBP)
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc DAPK Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis DAPK
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK Beclin1 Atg4 p62 PINK1/Parkin PINK1/Parkin
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1 YB-1 poly (ADP ribose) glycohydrolase (PARG) OGG1 STK33 NEKs ClpP
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK Annexin A
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK TET Protein SF3B1 METTL3 WDR5 Glycosyltransferase
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 TSH Receptor Protease Activated Receptor (PAR) Urotensin Receptor Vasopressin Receptor Motilin Receptor TF RXFP Receptor RGS Protein GPR68 Taste Receptor PACAP Receptor GPR81 GPR171 Trace Amine-associated Receptor (TAAR)
Immunology/Inflammation

Arginase Aryl Hydrocarbon Receptor (AhR) CCR Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 Salt-inducible Kinase (SIK) SOD SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) AP-1 PSMA Glucocorticoid Receptor (GR) FAP Histamine Receptor Macrophage migration inhibitory factor (MIF) LAG-3 Mucin Mesothelin Nectin-4 P-selectin TROP2 DPEP3 BCMA MUC16 BAFF CD markers FcRn CSF2 IgE Glycoprotein VI Kallikrein CD47 BCL6

Ack1

活化的Cdc42结合蛋白激酶1 (Activated Cdc42 kinase 1; )

ACK1/TNK2（活化的Cdc42相关激酶）是一种非受体酪氨酸激酶，最初通过与 GTP 结合的小 GTP 酶 Cdc42 结合而被鉴定。它在人体中广泛表达，被 EGF、PDGF、TGF-β 等多种细胞外生长因子激活。激活的 ACK1 通过与下游效应子相互作用并使其磷酸化来介导信号级联反应。近年来对 ACK1 生物学功能及其参与癌症的研究多有报道，在肺癌、卵巢癌和前列腺癌等多种癌症中均发现 ACK1 的基因扩增和过表达，并与不良预后和转移表型相关，表明 ACK1 是癌症治疗的潜在靶点。因此，以 ACK1 为靶点研发高效选择性的小分子抑制剂可为癌症治疗提供潜在的候选药物。

Ack1 相关靶点

全部(3) Ack1抑制剂(3)

货号	产品名	产品描述
SJ-MX4449	GNF-7	GNF-7是一种多靶点激酶抑制剂。GNF-7 是 Bcr-Abl 的抑制剂，对 Bcr-Abl ^WT 和 Bcr-Abl ^T315I作用的 IC50 值分别为 133 nM 和 61 nM。GNF-7 对 CDC42激酶1 (ACK1)和生发中心激酶(GCK) 也具有抑制活性，IC50 分别为 25 nM 和 8 nM。GNF-7诱导携带NRAS突变的白血病细胞的细胞周期阻滞和凋亡，可用于血液恶性肿瘤的研究。
SJ-MX3540	KRCA-0008	KRCA-0008是一种强效的、选择性ALK (间变性淋巴瘤激酶)和ACK1双重抑制剂，对 ALK 和 Ack1 的 IC50 值分别为 12 和 4 nM。KRCA-0008 可用于癌症的研究。
SJ-MX2343	AIM-100	AIM-100 是一种有效的选择性 Ack1 抑制剂，IC50 为 21.58 nM。AIM-100 还抑制 Tyr267 磷酸化，但不抑制其他激酶，包括 PI3K 和 AKT 亚家族成员。AIM-100 具有抗癌作用。