货号 | 产品名 | 中文名称 | 产品描述 |
---|---|---|---|
SJ-MX3299 | Lesinurad sodium | 雷西那德钠 | Lesinurad (RDEA-594) sodium is a selective uric acid reabsorption inhibitor (SURI). Lesinurad sodium also inhibits the uric acid transporter URAT1 and Kidney transporter OAT with IC50/Km of 4.3 μM/0.85 μM and 3.5 μM/2 μM for OAT1 and OAT3, respectively. |
SJ-MX3383 | Lesinurad | 雷西那德 |
Lesinurad (RDEA594) 是一种 URAT1 和 OAT 抑制剂,被确定为肾脏转运蛋白 OAT1 和 OAT3 的底物,其 Km 值分别为 0.85 和 2 µM。 |
SJ-MX3524 | Verinurad | 维立诺雷 | Verinurad is a highly potent and specific URAT1 inhibitor (IC50 value of 25 nM) with greater than 100-fold potency for URAT1 compared to other transporters. Under evaluation for the treatment of gout and asymptomatic hyperuricemia. |
SJ-MX6063 | Dotinurad | 多替诺德 | Dotinurad (FYU-981)是一种选择性的URAT1抑制剂,IC50为37.2 nM。对原代人肾近端小管上皮细胞(RPTECs)的尿酸摄取和URAT1介导的尿酸转运有显著抑制活性。 |