SJ-MX3299
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Lesinurad sodium
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雷西那德钠 |
Lesinurad (RDEA-594) sodium is a selective uric acid reabsorption inhibitor (SURI). Lesinurad sodium also inhibits the uric acid transporter URAT1 and Kidney transporter OAT with IC50/Km of 4.3 μM/0.85 μM and 3.5 μM/2 μM for OAT1 and OAT3, respectively.
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SJ-MX3383
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Lesinurad
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雷西那德 |
Lesinurad (formerly RDEA-594; RDEA594; trade name: Zurampic) is a potent and selective URAT1 (urate transporter 1) inhibitor. It can reduce the reuptake of uric acid from urine to blood circulation, thus lowering urate levels in the plasma. It is also an OAT (organic anion transporter) inhibitor thus may cause drug-drug interactions with other medications that are also OAT substrates. Lesinurad belongs to the so called SURI (selective uric acid reabsorption inhibitor).
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SJ-MX3524
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Verinurad
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维立诺雷 |
Verinurad is a highly potent and specific URAT1 inhibitor (IC50 value of 25 nM) with greater than 100-fold potency for URAT1 compared to other transporters. Under evaluation for the treatment of gout and asymptomatic hyperuricemia.
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