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URAT1

URAT1相关产品(3)
货号 产品名 中文名称 产品描述
SJ-MX3299 Lesinurad sodium 雷西那德钠 Lesinurad (RDEA-594) sodium is a selective uric acid reabsorption inhibitor (SURI). Lesinurad sodium also inhibits the uric acid transporter URAT1 and Kidney transporter OAT with IC50/Km of 4.3 μM/0.85 μM and 3.5 μM/2 μM for OAT1 and OAT3, respectively.
SJ-MX3383 Lesinurad 雷西那德 Lesinurad (formerly RDEA-594; RDEA594; trade name: Zurampic) is a potent and selective URAT1 (urate transporter 1) inhibitor. It can reduce the reuptake of uric acid from urine to blood circulation, thus lowering urate levels in the plasma. It is also an OAT (organic anion transporter) inhibitor thus may cause drug-drug interactions with other medications that are also OAT substrates. Lesinurad belongs to the so called SURI (selective uric acid reabsorption inhibitor).
SJ-MX3524 Verinurad 维立诺雷 Verinurad is a highly potent and specific URAT1 inhibitor (IC50 value of 25 nM) with greater than 100-fold potency for URAT1 compared to other transporters. Under evaluation for the treatment of gout and asymptomatic hyperuricemia.