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Angiotensin Receptor

Angiotensin Receptor相关产品(32)
货号 产品名 中文名称 产品描述
SJ-BP0036 Angiotensin II human Acetate 人醋酸血管紧张素II

Angiotensin II human是⼀种⾎管收缩剂,是肾素/⾎管紧张素系统(renin-angiotensin system,RAS)的主要⽣物活性肽。Angiotensin II human 在调节⼈类⾎压中起着核⼼作⽤,主要通过⾎管紧张素 II 与 G 蛋⽩偶联受体 (GPCRs)、⾎管紧张素II 1型受体 (AT1R) 和⾎管紧张素II 2型受体 (AT2R) 之间的相互作⽤来介导。

SJ-MX0401 Sacubitril/valsartan (LCZ696) 沙库必曲/缬沙坦 Sacubitril/Valsartan (LCZ696) 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成,摩尔比为 1:1,是一种首创的,口服有效的血管紧张素受体-脑啡肽酶 (ARN) 双抑制剂,用于研究高血压和心力衰竭。Sacubitril/Valsartan 可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病。
SJ-MX2874 Fimasartan 非马沙坦

Fimasartan是一种口服有效的血管紧张素受体非肽类拮抗剂。可与AT1受体非竞争性地、紧密地结合。Fimasartan用于高血压和心力衰竭的治疗中。

SJ-MX3382 PD 123319 ditrifluoroacetate PD 123319 ditrifluoroacetate is a potent, selective, non-peptide angiotensin AT2 receptor antagonist (IC50 values are 34 and 210 nM in rat adrenal tissue and brain respectively). It has been used to selectively examine the specific roles for AT1R and AT2R in hypertensive and other vascular research-related models.
SJ-MX3387 AVE 0991 AVE0991, a non-peptide Ang-(1-7) mimetic, is a selective and orally active Mas receptor agonist (IC50 value of 21 nM).
SJ-MX3512 CGP-42112 CGP-42112(also known as CGP-42112A) is a novel, potent and selective Angiotensin-II subtype 2 receptor(AT2 R) agonist. Angiotensin II subtype 2 receptor (AT(2)-R) is abundantly expressed in adrenal medullary chromaffin cells. However, the physiological roles of AT(2)-R in chromaffin cells remain to be clarified. CGP42112 (>==1 nM) significantly inhibited cGMP production from the basal value. Tyrosine hydroxylase (TH) is a rate-limiting enzyme in the biosynthesis of catecholamine, and its activity is regulated by both TH-enzyme activity and TH-synthesis. CGP42112 (>==1 nM) significantly inhibited TH-enzyme activity from the basal value. These inhibitory effects of CGP42112 on TH-enzyme activity and-cGMP production were abolished by PD123319 (AT(2)-R antagonist) while CV-11974 (AT(1)-R antagonist) was ineffective.
SJ-BP0206 Angiotensin II (3-8), human Angiotensin II (3-8), human 是一种活性稍弱的血管紧张素 AT1 受体激动剂。
SJ-MX2722 Tasosartan 他索沙坦 Tasosartan (ANA-756, AC1Q6LAA, DB01349, WAY-ANA-756, Verdia) is a long-acting angiotensin II (AngII) receptor antagonist.
SJ-MX1587 Sparsentan Sparsentan (RE-021) 是高度选择的血管紧张素 II (angiotensin II) 和内皮素 A (endothelin A) 受体的双重拮抗剂,Ki 值分别为 0.8 和 9.3 nM。
SJ-MX0802 Eprosartan Mesylate 甲磺酸依普罗沙坦 Eprosartan mesylate (SKF-108566J) 是一种选择性,竞争性,非肽和具有口服活性的血管紧张素 II 受体 (angiotensin II receptor) 拮抗剂,可用作降压剂。Eprosartan mesylate 结合血管紧张素 II 受体,在大鼠和人类肾上腺皮质膜中的 IC50 值分别为 9.2 nM 和 3.9 nM。
SJ-BP0108 A 779

A 779 是G蛋白偶联受体Mas的有效拮抗剂,区别于传统的AngII,Mas受体为一种Ang1-7 receptor。

SJ-BP0036A Angiotensin II human 血管紧张素Ⅱ

Angiotensin II human 是⼀种⾎管收缩剂,是肾素/⾎管紧张素系统(renin-angiotensin system,RAS)的主要⽣物活性肽。Angiotensin II human在调节⼈类⾎压中起着核⼼作⽤,主要通过⾎管紧张素 II 与 G 蛋⽩偶联受体 (GPCRs)、⾎管紧张素II 1型受体 (AT1R) 和⾎管紧张素II 2型受体 (AT2R) 之间的相互作⽤来介导。

SJ-BP0185 Alamandine Alamandine 是一种血管活性肽,是肾素-血管紧张素系统 (RAS) 的一个组成部分,还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可以调节血压,通过抗高血压作用来保护肾脏和心脏。
SJ-MX2516 Azilsartan 阿齐沙坦 Azilsartan(TAK-536) is a potent angiotensin II type 1 (AT1) receptor antagonist with an IC50 value of 2.6 nM.
SJ-MX2680 Olmesartan 奥美沙坦 Olmesartan (RNH-6270) is a potent and selective nonpeptide antagonist at the angiotensin II AT1-receptor subtype with an IC50 value of 6.7 nM.
SJ-MX2769 Olmesartan medoxomil 奥美沙坦酯 Olmesartan Medoxomil (formerly CS-866; Olmetec; Azor; Benicar; Olsertain), the medoxomil ester prodrug form of Olmesartan, is a potent and selective angiotensin II type 1/AT1 receptor antagonist with anti-hypertensive effects. It has been approved for use in the treatment of high blood pressure. It also inhibits the negative regulatory feedback on renin secretion. The result of receptor inhibition is vasodilation and a reduction in peripheral resistance. Olmesartan Medoxomil significantly reduces liver hydroxyproline content, and TGF-beta1.
SJ-MX2770 Telmisartan 替米沙坦 Telmisartan is a highly potent and selective nonpeptide AT1 receptor antagonist (Ki value of 3.7 nM for rat AT1 receptors).
SJ-MX0920A Losartan (DuP 753) 洛沙坦;氯沙坦 Losartan 是血管紧张素II受体拮抗剂,与血管紧张素II竞争性结合AT1受体,IC50为20 nM。
SJ-MX2107 Valsarta (CGP 48933) 缬沙坦 Valsarta (CGP 48933) 是血管紧张素 II (angiotensin II) 受体拮抗剂,有潜力用于高血压和心力衰竭的研究。
SJ-MX2108 Candesartan 坎地沙坦 Candesartan是血管紧张素II受体拮抗剂,IC50为0.26 nM。