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信号通路

Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease RABV HPV RABV EBV Dengue Virus β-lactamase Flavivirus VSV Penicillin-binding protein (PBP)
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis DAPK Disulfidptosis
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK Beclin1 Atg4 p62 PINK1/Parkin
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1 YB-1 poly (ADP ribose) glycohydrolase (PARG) OGG1 STK33 NEKs ClpP
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK Annexin A
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK TET Protein SF3B1 METTL3 WDR5 Glycosyltransferase
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 Protease Activated Receptor (PAR) Urotensin Receptor Vasopressin Receptor Motilin Receptor TF RXFP Receptor RGS Protein GPR68 Taste Receptor PACAP Receptor GPR81 GPR171 Trace Amine-associated Receptor (TAAR)
Immunology/Inflammation

Arginase Aryl Hydrocarbon Receptor (AhR) CCR Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 Salt-inducible Kinase (SIK) SOD SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) PSMA Glucocorticoid Receptor (GR) FAP Histamine Receptor Macrophage migration inhibitory factor (MIF) LAG-3 Mucin Mesothelin Nectin-4 P-selectin TROP2 DPEP3 BCMA MUC16 BAFF CD markers FcRn CSF2 IgE Glycoprotein VI Kallikrein CD47 BCL6

Reactive Oxygen Species

活性氧

Reactive Oxygen Species(ROS)由氧部分还原形成的自由基和非自由基氧组成，如超氧阴离子(O₂^-•)、过氧化氢(H₂O₂)、羟基自由基(•OH^-)和一氧化氮等，半衰期较短，脂溶性。细胞内ROS是在线粒体氧化代谢以及细胞对外源物质、细胞因子和细菌入侵的反应过程中产生的。

体内ROS主要是在线粒体电子传递链由状态II向状态IV转换中产生，高水平O2的环境使高还原态的呼吸链电子由呼吸链底物端和氧端漏出并交给O2而生成O₂^-。正常时约2%的氧参与ROS的产生。在生理条件下,适量的ROS可促进免疫、修复.存活、生长等。消除ROS的抗氧化体系,分为酶系和非酶系,前者有超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶（GPx)等,后者主要是还原型谷胱甘肽(GSH)、维生素C/E等。细胞内高水平GSH、CAT(H2O2酶)、GPx、SOD、环孢素A、Bcl-2，可下调ROS。

过量的ROS可与线粒体电子传递链多种蛋白硫氧还中心的Fe-S簇的Cys反应,形成蛋白的S-谷胱甘肽化的加合物。过量的ROS,可损伤生长因子、转录因子、蛋白质、核酸、糖类脂类等。ROS也通过直接抑制MAPK磷酸酶来激活MAPK途径。通过PTEN，PI3K通路受到生长因子刺激产生的ROS的可逆性氧化还原调节。自噬的激活可能是机体应对ROS的一种细胞防御机制。

Reactive Oxygen Species 相关靶点

全部(444) Reactive Oxygen Species抑制剂(197) Reactive Oxygen Species激活剂(63) Reactive Oxygen Species诱导剂(35) Reactive Oxygen Species激动剂(3) Reactive Oxygen Species调节剂(3) Reactive Oxygen Species其他(137)

货号	产品名	中文名称	产品描述
SJ-MX5242	Triphenyl phosphate	磷酸三苯基酯	Triphenyl phosphate 是一种有机磷酸盐阻燃剂。Triphenyl phosphate 可通过激活 MAOA/ROS/NFκB 破坏胎盘色氨酸代谢，诱发异常的神经行为。Triphenyl phosphate 促进核因子 κ B (NFκB)、白细胞介素-6、肿瘤坏死因子α 等炎症因子诱导氧化应激。Triphenyl phosphate 可引起过敏性接触性皮炎。
SJ-MX10843	NQO2-IN-1		NQO2-IN-1 (Compound 20b) 是醌氧化还原酶（NQO）的抑制剂，可抑制 NQO2，IC50 为 95 nM。NQO2-IN-1 通过诱导 ROS 和细胞凋亡 (apoptosis) 克服 NSCLC 细胞对肿瘤坏死因子相关凋亡诱导配体 (TRAIL) 的抗性。
SJ-MX6986	ROS inducer 2		ROS inducer 2 (Compound I16) 是一种活性氧诱导剂。ROS inducer 2 具有良好的体外活性，EC50 为 3.43 μg/mL。ROS inducer 2 对 Xanthomonas axonopodis pv. citri 具有出色的体内生物活性。ROS inducer 2 可作为杀菌剂，用于难治性植物细菌性疾病的研究。
SJ-MX10871	L-Selenocystine	L-硒代胱氨酸	L-Selenocystine 是一种含硒的氨基酸。L-Selenocystine 具有氧化还原的性质。L-Selenocystine 对多种肿瘤细胞具有细胞毒性，可诱导 ROS 产生和细胞凋亡 (apoptosis)。此外，L-Selenocystine 可阻断 Nrf2 和自噬 (autophagy) 通路。L-Selenocystine 具有抗肿瘤的活性。