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Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease RABV HPV DENV RABV
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc DAPK Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis DAPK
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK Beclin1 Atg4
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex Haspin Kinase HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog p97 PAK PARP PERK PFKFB3 Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1 YB-1 poly (ADP ribose) glycohydrolase (PARG) OGG1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK TET Protein
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR MCHR1 (GPR24) Melanocortin Receptor Melatonin Receptor mGluR Motilin Receptor Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Mas-related G-protein-coupled Receptor (MRGPR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 TSH Receptor Protease Activated Receptor (PAR) Urotensin Receptor Vasopressin Receptor Motilin Receptor TF
Immunology/Inflammation

Arginase Aryl Hydrocarbon Receptor (AhR) CCR Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 Salt-inducible Kinase (SIK) SOD SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) AP-1 PSMA Glucocorticoid Receptor (GR) FAP Histamine Receptor Macrophage migration inhibitory factor (MIF) LAG-3 Mucin Tim3 Mesothelin Nectin-4 P-selectin TROP2 CD79B DPEP3 BCMA MUC16 BAFF CD markers FcRn CSF2 IgE Glycoprotein VI

PARP

poly ADP ribose polymerase (多聚ADP核糖聚合酶)

聚（ADP-核糖）聚合酶（PARP）是一个蛋白质家族，参与许多细胞过程，主要涉及DNA修复和程序性细胞死亡。PARP 家族由17个成员组成，参与介导一系列细胞过程，包括基因转录和DNA修复，与人类疾病发生密切相关。PARP蛋白家族根据聚 ADP 核糖基化和单 ADP核糖基化分为两组。其中 PARP1, PARP2, VPARP (PARP4)， tankyase -1和-2 (PARP-5a或TNKS，以及PARP-5b或TNKS2) 具有确认的PARP活性。其他包括:PARP3、PARP6、TIPARP(或PARP7)、PARP8、PARP9、PARP10、PARP11、PARP12、PARP14、PARP15、PARP16。PARP 存在于细胞核中，其主要作用是检测单链DNA断裂(SSB)并向参与单链DNA修复的酶机制发出信号。

PARP 相关靶点

全部(105) PARP抑制剂(95) PARP激活剂(3) PARP诱导剂(5) PARP降解剂(1)

货号	产品名	中文名称	产品描述
SJ-MN1000	5,7-dihydroxychromone	5,7-二羟基色酮	5,7-Dihydroxychromone 是一种从 Cudrania tricuspidata 中提取的天然抗氧化剂，是 Nrf2/ARE 信号的有效激活剂。5,7-Dihydroxychromone也是 PPARγ 和 LXRα 的有效激活剂。5,7-Dihydroxychromone可能有助于调节血糖水平并显示抗糖尿病特性。
SJ-MX5568	2-Methylquinazolin-4-ol	2-甲基-4(3H)-喹唑酮	2-Methylquinazolin-4-ol 是一种高效、竞争性的 poly(ADP-ribose) synthetase 抑制剂，其 Ki 值为 1.1 μM。2-Methylquinazolin-4-ol 是哺乳动物天冬氨酸氨基转移酶 (ATCase) 抑制剂，其 IC50 值为 0.20 mM。
SJ-MN1549A	Dehydrocorydaline nitrate	脱氢紫堇碱	Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) 是一种生物碱。Dehydrocorydaline 调节 Bax，Bcl-2 蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。Dehydrocorydaline nitrate 能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。Dehydrocorydaline nitrate 具有强大的抗疟疾作用，并具低细胞毒性 (细胞生存力 > 90％)， P. falciparum 3D7 strain (IC50=38 nM)。
SJ-MX0068B	Niraparib (MK-4827) tosylate monohydrate	甲苯磺酸尼拉帕尼一水物	Niraparib (MK-4827) tosylate monohydrate 是一种高效的，具有生物口服利用度的 PARP1 和 PARP2 抑制剂，IC50 分别为 3.8 nM 和 2.1 nM。Niraparib (MK-4827) tosylate monohydrate 可在有 BRCA 和 PTEN 功能缺陷的临床肿瘤模型中引起合成致死性。Niraparib (MK-4827) tosylate monohydrate 抑制 DNA 损伤修复，诱导凋亡 (apoptosis) 并具有抗肿瘤活性。
SJ-MN1212	Paris saponin VII	重楼皂苷Ⅶ	Paris saponin VII (Chonglou Saponin VII) 是从延龄草 (Trillium tschonoskii Maxim) 的根和根茎中分离的甾体皂苷。Paris saponin VII 诱导的 K562/ADR 细胞凋亡与 Akt/p38 MAPK 和 P-gp 的抑制有关。Paris saponin VII 减弱线粒体膜电位，增加凋亡相关蛋白 (Bax 和细胞色素 c) 的表达，并降低 Bcl-2，caspase-9，caspase-3，PARP-1 和 p-Akt 的蛋白表达水平。Paris saponin VII 在 K562/ADR 细胞中诱导强烈的自噬，可用于白血病的研究。