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核苷酸代谢（Nucleotide Metabolism）是细胞增殖的核心环节，为DNA复制、RNA合成及核糖体生物发生提供必需原料。其合成路径高度依赖多种代谢来源，如核糖-5-磷酸来自磷酸戊糖途径，碳氮元素来自氨基酸。该途径含多种抗癌药的重要作用靶点[1,2]。
图1. 嘌呤和嘧啶核苷酸的生物合成途径、相关抑制剂及致癌调控因子[2] [1] Stine Zachary E, et al. Targeting cancer metabolism in the era of precision oncology. Nature Reviews Drug Discovery, vol. 21, no. 2, Feb. 2022, pp. 141–62. [2] Mullen Nicholas J, et al. Singh. Nucleotide Metabolism: A Pan-Cancer Metabolic Dependency. Nature Reviews Cancer, vol. 23, no. 5, May 2023, pp. 275–94.
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