货号 | 产品名 | 中文名称 | 产品描述 |
---|---|---|---|
SJ-MX1927B | Enalaprilat | 依那普利拉 |
Enalaprilat (MK-422 anhydrous) 是口服前体 Enalapril 的活性代谢物,是一种有效,竞争性和长效的血管紧张素转换酶 (ACE) 抑制剂,IC50 值为 1.94 nM。Enalaprilat 可用于高血压的研究。 |
SJ-MX1927C | Enalapril | 依那普利 |
Enalapril (MK-421) 是一种血管紧张素转换酶 (ACE) 抑制剂,可用于高血压疾病的研究。 |
SJ-MX2945 | Temocapril hydrochloride | 盐酸替莫普利 | Temocapril hydrochloride 是一种具有口服活性的长效血管紧张素转化酶 (ACE) 抑制剂。Temocapril hydrochloride 可以用于高血压、充血性心力衰竭、急性心肌梗死、胰岛素抵抗和肾脏疾病的研究。 |
SJ-MX3328 | Zofenopril calcium | 佐芬普利钙 |
Zofenopril Calcium (SQ26991) 是抗氧化剂和血管紧张素转化酶 (ACE) 抑制剂。Zofenopril Calcium可以保护心脏,有助于降低高血压。 |
SJ-MX3779 | Omapatrilat | Omapatrilat (also known as BMS-186716) is a novel antihypertensive agent that acts as a potent dual inhibitor of the metalloproteases ACE (angiotensin converting enzyme) and NEP (neutral endopeptidase) with Ki values of 0.64 and 0.45 nM, respectively. Omapatrilat has antihypertensive activity. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. The drug was promoted for possible uses in congestive heart failure. | |
SJ-MX2496 | Alacepril |
Alacepril (Cetapril; DU-1219) 是一种具有长效抗高血压作用的口服活性血管紧张素转换酶 (ACE) 抑制剂,通常用作降压药。 |
|
SJ-BP0189 | Lisinopril | 赖诺普利 | Lisinopril (MK-521; MK521; Zestril; Linopril; Lisipril) is a potent angiotensin-converting enzyme (ACE) inhibitor approved for use in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. |
SJ-MX1927A | Enalapril maleate | 马来酸依那普利 |
Enalapril (MK-421) maleate 是血管紧张素转化酶(ACE)抑制剂,用于治疗高血压,糖尿病肾病以及慢性心力衰竭。 |
SJ-MX2556 | Fosinopril sodium | 福辛普利钠 | Fosinopril (sodium) 是血管紧张素转换酶(ACE)抑制剂的原药,IC50 为 0.18 μM,Ki 值为 1.675 μM。在体内, Fosinopril 在胃肠道黏膜和肝脏中迅速水解为 fosinoprilat。 Fosinopril (sodium)可作用于高血压和慢性心力衰竭。 |
SJ-MX2832 | Quinapril hydrochloride | Quinapril (hydrochloride) (CI-906) 是血管紧张素转化酶 (ACE) 抑制剂的原药。 | |
SJ-MX2837 | Benazepril hydrochloride | 盐酸贝那普利 | Benazepril hydrochloride是血管紧张素转化酶(ACE)抑制剂,可作用于高血压。 |
SJ-MX2838 | Benazepril | 贝那普利 | Benazepril 是血管紧张素转化酶(ACE)抑制剂,可作用于高血压。 |
SJ-MX3326 | Captopril (SQ 14225) | 卡托普利 |
Captopril (SQ 14225) 是一种含巯基的口服活性血管紧张素转换酶 (ACE) 抑制剂,IC50=0.025 μM。Captopril 也是 NDM-1 抑制剂,IC50 值为 7.9 μM。Captopril 广泛应用于高血压和充血性心力衰竭的研究。Captopril 被证明可通过诱发细胞凋亡而影响细胞生长,进而发挥抗癌活性。 |
SJ-MX3359 | Perindopril erbumine | 培哚普利叔丁胺 |
Perindopril erbumine (Perindopril tert-butylamine salt) 是一种长效的、脑通透性的血管紧张素转换酶(ACE)抑制剂(IC50 = 1.05 nM)。不同于其他ACE抑制剂,它通过抑制VEGF水平抑制肝癌细胞的肿瘤生长,也在体外抑制血管紧张素 II 的产生。
|
SJ-MX3412 | Imidapril hydrochloride | 盐酸咪达普利 | Imidapril hydrochloride is a prodrug for the active metabolite imidaprilat, an angiotensin-converting enzyme (ACE) inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC50 = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex which leads to an increase in sodium excretion and subsequently increases water outflow. |
SJ-MX3937 | Delapril hydrochloride | Delapril hydrochloride 是一种血管紧张素转化酶 (ACE) 抑制剂,可用于心血管疾病的研究。 | |
SJ-MX4490 | Cilazapril monohydrate | Cilazapril monohydrate is a pyridazine angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. | |
SJ-MX4491 | Trandolapril | Trandolapril (RU-44570), an antihypertensive drug, is an oral and nonsulfhydryl prodrug that has to be hydrolysed to the active diacid Trandolaprilat. It is a potent ACE inhibitor used to treat high blood pressure. | |
SJ-MX4492 | Ramipril | 雷米普利 | Ramipril is a non-peptide, angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). A prodrug that is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Displays antihypertensive effects. |
SJ-MX4494 | Moexipril hydrochloride | 盐酸莫西普利 | Moexipril hydrochloride is a prodrug of the long-acting angiotensin converting enzyme (ACE) inhibitor moexiprilat (IC50s = 2.1 nM and 2.7 µM for moexiprilat and moexipril, respectively). Moexipril hydrochloride has been identified as a phosphodiesterase 4 inhibitor (IC50 = 38 µM for the PDE4B2 isoform) that increases cAMP in cells. |