货号 | 产品名 | 中文名称 | 产品描述 |
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SJ-MX3779 | Omapatrilat | Omapatrilat (also known as BMS-186716) is a novel antihypertensive agent that acts as a potent dual inhibitor of the metalloproteases ACE (angiotensin converting enzyme) and NEP (neutral endopeptidase) with Ki values of 0.64 and 0.45 nM, respectively. Omapatrilat has antihypertensive activity. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. The drug was promoted for possible uses in congestive heart failure. | |
SJ-MX2496 | Alacepril | Alacepril, also known as Cetapril and DU-1219, is an angiotensin-converting enzyme inhibitor and is commonly used as an antihypertensive. | |
SJ-BP0185 | Alamandine | Alamandine 是一种血管活性肽,是肾素-血管紧张素系统 (RAS) 的一个组成部分,还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可以调节血压,通过抗高血压作用来保护肾脏和心脏。 | |
SJ-MX1927A | Enalapril maleate | 马来酸依那普利 | Enalapril maleate is a potent angiotensin converting-Enzyme (ACE) inhibitor used to treat for hypertension and heart failure. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. |
SJ-MX2556 | Fosinopril sodium | 福辛普利钠 | Fosinopril sodium is the ester prodrug of fosinoprilat, an angiotensin converting enzyme (ACE) inhibitor. In vivo, fosinopril is rapidly hydrolyzed to fosinoprilat in the gastrointestinal mucosa and liver. |
SJ-MX2832 | Quinapril hydrochloride | Quinapril hydrochloride (formerly CI-906, PD-109452-2; Acequin; Korec; Accupril; Accuprin; Accupril), the hydrochloride salt form of quinapril which is the prodrug of quinaprilat, is an angiotensin-converting enzyme/ACE inhibitor with anti-hypertensive effects. It is an approved antihypertensive drug that inhibits ACE with a Ki of 20 μM. Quinapril is a prodrug that has to to be converted in vivo to its active metabolite, quinaprilat. | |
SJ-MX2837 | Benazepril hydrochloride | 盐酸贝那普利 | Benazepril hydrochloride is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat. It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM). Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats. |
SJ-MX2838 | Benazepril | 贝那普利 | Benazepril (CGS-14824A; Cibacène; Cibacen; Briem; Labopal; Lotensin), a prodrug that has to be metabolized to the active form benazeprilat, is an angiotensin I converting enzyme (ACE) inhibitor that has approved for treatment of hypertension. |
SJ-MX3326 | Captopril (SQ 14225) | 卡托普利 | Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 μM for leukotriene B4> formation and Ki = 60 nM for L-lysine-p-nitroanilide). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent. |
SJ-MX3412 | Imidapril hydrochloride | 盐酸咪达普利 | Imidapril hydrochloride is a prodrug for the active metabolite imidaprilat, an angiotensin-converting enzyme (ACE) inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC50 = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex which leads to an increase in sodium excretion and subsequently increases water outflow. |
SJ-MN1281 | Sinapinic acid | 芥子酸 | Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物,为 HDAC 的抑制剂,IC50 值 2.27 mM,对 ACE-I 的活性也有抑制作用。Sinapinic acid 具有有效的抗肿瘤活性,诱导肿瘤细胞凋亡。Sinapinic acid 具有抗氧化、抗糖尿病的作用。Sinapinic acid 可以降低卵巢切除大鼠的总胆固醇、甘油三酯和 HOMA-IR 指数,并使抗氧化能力和氧化损伤的一些血清参数正常化。 |
SJ-MX4492 | Ramipril | 雷米普利 | Ramipril is a non-peptide, angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). A prodrug that is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Displays antihypertensive effects. |
SJ-BP0189 | Lisinopril | 赖诺普利 | Lisinopril (MK-521; MK521; Zestril; Linopril; Lisipril) is a potent angiotensin-converting enzyme (ACE) inhibitor approved for use in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain. |
SJ-MX2945 | Temocapril hydrochloride | 盐酸替莫普利 | Temocapril hydrochloride is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, it is used for the treatment of hypertension. Temocapril is a prodrug-type ACE inhibitor not approved for use in the United States, but is approved in Japan and South Korea. Temocapril can also be used in hemodialysis patients without risk of serious accumulation. |
SJ-MX4490 | Cilazapril monohydrate | Cilazapril monohydrate is a pyridazine angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. | |
SJ-MX4491 | Trandolapril | Trandolapril (RU-44570), an antihypertensive drug, is an oral and nonsulfhydryl prodrug that has to be hydrolysed to the active diacid Trandolaprilat. It is a potent ACE inhibitor used to treat high blood pressure. | |
SJ-MX3937 | Delapril hydrochloride | Delapril hydrochloride 是一种血管紧张素转化酶 (ACE) 抑制剂,可用于心血管疾病的研究。 | |
SJ-MX3328 | Zofenopril calcium | 佐芬普利钙 |
Zofenopril Calcium (SQ26991) 是抗氧化剂和血管紧张素转化酶 (ACE) 抑制剂。Zofenopril Calcium可以保护心脏,有助于降低高血压。 |
SJ-MX3359 | Perindopril erbumine | 培哚普利叔丁胺 |
Perindopril erbumine (Perindopril tert-butylamine salt) 是一种长效的、脑通透性的血管紧张素转换酶(ACE)抑制剂(IC50 = 1.05 nM)。不同于其他ACE抑制剂,它通过抑制VEGF水平抑制肝癌细胞的肿瘤生长,也在体外抑制血管紧张素 II 的产生。
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SJ-MX4494 | Moexipril hydrochloride | 盐酸莫西普利 | Moexipril hydrochloride is a prodrug of the long-acting angiotensin converting enzyme (ACE) inhibitor moexiprilat (IC50s = 2.1 nM and 2.7 µM for moexiprilat and moexipril, respectively). Moexipril hydrochloride has been identified as a phosphodiesterase 4 inhibitor (IC50 = 38 µM for the PDE4B2 isoform) that increases cAMP in cells. |