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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MX1051 | PF-06282999 |
PF-06282999是一种有效的，选择性的、不可逆的的髓过氧物酶(myeloperoxidase，MPO)抑制剂，可以用于心血管疾病的研究。 |
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| SJ-MX3737 | Tinoridine hydrochloride | Tinoridine hydrochloride (also known as Y-3642 hydrochloride), the hydrochloride of tinoridine (Y-3642), is a nonsteroidal anti-inflammatory drug (NSAID) that also has potent radical scavenger and antiperoxidative activity. At concentrations from 5 μM to 100 μM, tinoridine can produce a concentration-dependent inhibition on the simultaneous increases in lipid peroxide formation and renin release induced by 50 μM ascorbic acid in the renin granule fraction. While other NSAIDs and steroids such as indomethacin, hydrocortisone and prednisolone do not inhibit the lipid peroxidation in the renin granule fraction, did not influence the release of renin from the granules, suggesting that tinoridine suppresses renin release by inhibiting the oxidative disintegration of membranes of renin granules. | |
| SJ-MX3993 | Verdiperstat | Verdiperstat (AZD3241) is a novel, potent, selective, irreversible and orally bioactive myeloperoxidase inhibitor with an IC50 of 630 nM. It is potentially useful in the treatment of neurodegenerative brain disorders. | |
| SJ-MX4199 | MPO-IN-28 | MPO-IN-28 (Compound 28) 是一种髓过氧化物酶 (MPO) 抑制剂，IC50 为 44 nM。 | |
| SJ-MN0811 | 4-Methylesculetin | 4-甲基七叶亭 | 4-Methylesculetin is an orally bioavailable natural coumarin analogue, with potent anti-oxidant and anti-inflammatory activities. 4-Methylesculetin inhibits myeloperoxidase activity and reduces IL-6 level. |
| SJ-MX0686 | ML162 |
ML162是一种 GPX4（谷胱甘肽过氧化物酶 4）抑制剂，对突变型 RAS 癌基因表达细胞系具有选择性致死性，对表达 HRASG12V 和野生型 BJ 成纤维细胞的 IC50 分别为 25 和 578 nM。ML162可诱导铁死亡（Ferroptosis）。 |
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| SJ-MX0040 | RSL3 |
RSL3 ((1S,3R)-RSL3) 是一种谷胱甘肽过氧化物酶 4 (GPX4) 的抑制剂 (ferroptosis 激动剂)，可降低 GPX4 的表达，诱导头颈部癌细胞的肥大性死亡。它结合并使GPX4失活，介导GPX4所调节的铁死亡。在 HN3 耐受细胞中，可增加 p62 和 Nrf2 的蛋白水平，使 Keap1 灭活。 |
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| SJ-MX0461 | ML 210 |
ML-210 是一种选择性，共价的谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂，EC50 为 40 nM。ML-210 结合 GPX4 硒代半胱氨酸残基。ML210 可诱导铁死亡。ML 210是选择性杀死诱导表达突变RAS的细胞的化学探针，并具有抗癌活性。 |
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| SJ-MX4830 | AZD5904 |
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