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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MX1042 | Finerenone | 非奈利酮 |
Finerenone (FIN, BAY 94-8862) 是第三代选择性、具有口服活性的、非甾体类盐皮质激素受体 (Mineralocorticoid Receptor，MR) 拮抗剂 (IC50=18 nM)。与糖皮质激素受体 (GR)、雄激素受体 (AR) 和孕酮受体 (AR) 相比，Finerenone 表现出良好的选择性 (>500-fold)。Finerenone 在心肾疾病研究中具有潜在的应用前景，如 2 型糖尿病和慢性肾脏疾病。 |
| SJ-MX3360 | Eplerenone | 依普利酮 | Eplerenone (also known as CGP 30083, Inspra, SC-66110) is a potent and selective mineralocorticoid receptor antagonist with an IC50 of 0.36 μM, it blocks the action of aldosterone, used to control high blood pressure. Eplerenone inhibits upregulated phosphorylation of PKCepsilon, MAP kinase, and p90RSK in Dahl salt-sensitive hypertensive (DS) rats. Eplerenone increases downregulated endothelial nitric oxide synthase mRNA in Dahl salt-sensitive hypertensive (DS) rats. Eplerenone administration results in significant improvement in glomerulosclerosis and urinary protein in DS rats. Eplerenone (200 mg/kg/day) administration significantly decreases systolic and diastolic blood pressure by 12% and 11%, respectively, compared with untreated mice. |
| SJ-MX4424 | Apararenone | Apararenone (MT-3995) is a novel, potent and selective non-steroidal mineralocorticoid/aldosterone receptor antagonist under development for the treatment of diabetic nephropathies and non-alcoholic steatohepatitis. The compound is thought to reduce renal tissue damage by preventing proteinuria. | |
| SJ-MX1944 | Spironolactone | 螺内酯 |
Spironolactone (SC9420) 是一种具有口服活性醛固酮盐皮质激素受体 (aldosterone mineralocorticoid receptor) 拮抗剂，IC50 值为 24 nM。Spironolactone 也是雄激素受体 (androgen receptor) 拮抗剂，IC50 为 77 nM。Spironolactone 促进足细胞自噬。 |
| SJ-MX1850 | Osilodrostat | Osilodrostat (LCI699; LCI-699; Isturisa) is a novel and potent inhibitor of 11β-hydroxylase and approved medication for the treatment of adults with Cushing's disease. | |
| SJ-MH0061 | Deoxycorticosterone acetate | 醋酸去氧皮质酮 | Deoxycorticosterone acetate is a novel and potent 21-acetate analogue of desoxycorticosterone. |
| SJ-MH0048 | Fludrocortisone acetate | 醋酸氟氢可的松 | Fludrocortisone Acetate, the acetate form of the synthetic corticosteroid fludrocortisone, is a potent mineralocorticoid receptor agonist. Fludrocortisone has been used in the treatment of cerebral salt wasting syndrome. |
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