SJ-MX0401
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Sacubitril/valsartan (LCZ696)
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沙库必曲/缬沙坦 |
Sacubitril/Valsartan (LCZ696) 是由 Valsartan (an ARB) 和 Sacubitril (AHU377) 组成,摩尔比为 1:1,是一种首创的,口服有效的血管紧张素受体-脑啡肽酶 (ARN) 双抑制剂,用于研究高血压和心力衰竭。Sacubitril/Valsartan 可通过抑制炎症、氧化应激和细胞凋亡来改善糖尿性心肌病。
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SJ-MX3289
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Sacubitril (AHU-377) hemicalcium salt
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Sacubitril (AHU-377) hemicalcium salt 是有效的NEP抑制剂,IC50值为5 nM。Sacubitril hemicalcium salt 是研究心力衰竭药物 LCZ696 的一个组分。
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SJ-MX3793
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Sacubitrilat
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Sacubitrilat (Desethyl Sacubitril, LBQ-657) 是一种活性的脑啡肽酶 (NEP) 抑制剂。
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SJ-MX2708
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Racecadotril
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消旋卡多曲 |
Racecadotril (also called acetorphan) is a potent and peripherally acting enkephalinase inhibitor used as an antidiarrheal medication. It protects endogenous enkephalins from degradation and has an IC50 of 4.5 μM against enkephalinase. Unlike other opioid medications used to treat diarrhea, which reduce intestinal motility, racecadotril has an antisecretory effect, it reduces the secretion of water and electrolytes into the intestine.
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SJ-MN0265
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Phosphoramidon Disodium
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磷酰二肽,膦酰二肽钠 |
Phosphoramidon Disodium 是金属蛋白酶 (metalloprotease) 抑制剂 。抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50 值分别为 3.5 ,0.034 和 78 μM。
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