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Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog Nur77 p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) Nucleoside Antimetabolite/AnalogOrthopoxvirus ROCK ATF6 Haspin Kinase Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Endocrinology/Hormones

Adrenergic Receptor Androgen Receptor Angiotensin-converting Enzyme (ACE) Aromatase Cholecystokinin Receptor TSH Receptor Estrogen Receptor/ERR GHSR Glucocorticoid Receptor GNRH Receptor Mineralocorticoid Receptor Opioid Receptor PGD synthase PGE synthase Progesterone Receptor Thyroid Hormone Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain FTO HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR27 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor E3 Ligase Ligand-Linker Conjugates RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Vasopressin Receptor

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Mitochondrial Metabolism

Mitochondrial Metabolism相关产品（47）

货号	产品名	中文名称	产品描述
SJ-MX0391	Devimistat (CPI-613)	德维司他	Devimistat (CPI-613) 是一种 lipoic acid拮抗剂和线粒体代谢抑制剂，在NCI-H460 细胞系中抑制线粒体酶pyruvate dehydrogenase (PDH)和α-ketoglutarate dehydrogenase，干扰肿瘤细胞线粒体代谢，诱导多种癌细胞凋亡。Devimistat (CPI-613) 旨在靶向线粒体三羧酸（TCA）循环选择性地作用于癌细胞，可显著增加癌细胞压力和癌细胞对多种化疗药物的敏感性。
SJ-MX0133	IACS-010759 (IACS-10759)		IACS-010759 (IACS-10759)是一种口服生物有效的氧化磷酸化复合物I(OXPHOS)的抑制剂。在依赖OXPHOS的脑癌和急性髓系白血病(AML)模型中，IACS-010759可显著抑制增殖和诱导凋亡。IACS-010759 具有用于复发/难治性 AML 和实体瘤研究的潜力。
SJ-MX0966	Gboxin		Gboxin是一种氧化磷酸化 (oxidative phosphorylation，OXPHOS) 抑制剂，可靶向抑制胶质母细胞瘤生长。Gboxin 抑制 F₀F₁ATP 合成，具有抗肿瘤活性。
SJ-MX0630	UK 5099		UK-5099 (PF-1005023) 是线粒体丙酮酸转运蛋白 (mitochondrial pyruvate carrier，MPC) 的有效抑制剂，抑制丙酮酸依赖性O2消耗的 IC50 值为50 nM。
SJ-MX1009	Lonidamine	氯尼达明	Lonidamine (AF 1890, Diclondazolic Acid, DICA) 是吲哚唑-3-羧酸的衍生物，是一种口服的小分子己糖激酶抑制剂，IC50为0.85 mM，具有抗肿瘤的功效。
SJ-BP0012	Elamipretide (MTP-131)		Elamipretide (MTP-131, SS-31, D-Arg-Dmt-Lys-Phe-NH2) 是一种 Cytochrome c peroxidase 的抑制剂。Elamipretide 可改善小鼠脂多糖诱导的线粒体功能障碍，突触和记忆障碍。
SJ-MX0415	MSDC 0160		MSDC 0160 (Mitoglitazone) 是调节噻唑烷二酮的线粒体靶标 (mTOT) 的胰岛素增敏剂，也是线粒体丙酮酸载体 (MPC) 的调节剂。MSDC 0160 是一种噻唑烷二酮 (TZD)，具有抗糖尿病和神经保护活性作用。MSDC 0160 具有用于阿尔茨海默氏病的潜力。
SJ-MX3539	7ACC2		7ACC2 is a potent MCT inhibitor. Monocarboxylate transporters (MCTs) catalyze the proton-linked transport of monocarboxylates such as L-lactate, pyruvate, and the ketone bodies across the plasma membrane. There are four isoforms, MCTs 1-4, which are known to perform this function in mammals, each with distinct substrate and inhibitor affinities.
SJ-MX4008	CCCP		CCCP 是氧化磷酸化 (OXPHOS) 解偶联剂，是线粒体质子载体解偶联剂，可增加线粒体膜对质子的通透性，从而破坏线粒体膜电位。CCCP 诱导 PINK1 激活，促进 Parkin 在 Ser65 位点磷酸化。
SJ-MX1901	VLX600		VLX600 是氧化磷酸化 (OXPHOS) 的铁螯合抑制剂。VLX600 导致线粒体功能障碍，并导致向糖酵解的强烈转变。VLX600 对恶性细胞表现出选择性的细胞毒活性，并诱导自噬 (autophagy)。具有抗癌活性。
SJ-MX1080	Mitochonic acid 5		Mitochonic acid 5 与线粒体结合，并改善肾小管和心肌细胞损伤。Mitochonic acid 5 调节线粒体 ATP 合成。
SJ-MN1414	Schaftoside	夏佛塔苷	Schaftoside 是在多种中草药（如 Eleusine indica）中发现的黄酮类化合物。Schaftoside 抑制 TLR4 和 Myd88 表达。 Schaftoside 还降低 Drp1 表达和磷酸化，并减少线粒体分裂。
SJ-MX3919	BAM 15		BAM15 is a mitochondrial protonophore uncoupler, which does not depolarize the plasma membrane. Compared to FCCP, an uncoupler of equal potency, BAM15 treatment of cultured cells stimulates a higher maximum rate of mitochondrial respiration and is less cytotoxic. Furthermore, BAM15 is bioactive in vivo and dose-dependently protects mice from acute renal ischemic-reperfusion injury.
SJ-MX4256	Tricarballylic acid	三碳烯丙酸	Tricarballylic acid 是一种三碳烯丙酸酯的共轭酸，是乌头酸水合酶 (aconitate hydratase) 的竞争性抑制剂，其 Ki 值为 0.52 mM。
SJ-MX4335	CCI-006		CCI-006 是 MLL-重组白血病细胞的选择性抑制剂和化学增敏剂，通过抑制线粒体呼吸，导致 MLL-重组白血病细胞中不可克服的线粒体去极化和促凋亡的未折叠蛋白反应。
SJ-MX4367	Adjudin		Adjudin is a non-hormonal male contraceptive that exerts its effect by disrupting Sertoli-germ cell adhesion junctions, most notably apical ectoplasmic specialization (apical ES), by targeting testin and actin filament bundles that disrupt the actin-based cytoskeleton in Sertoli cells. Adjudin is a potent blocker of Cl- channels. Moreover, Adjudin is shown to induce apoptosis in cancer cells through a Caspase-3-dependent pathway, and triggers mitochondrial dysfunction in cancer cells.
SJ-MX4677	L-2-Hydroxyglutaric acid disodium		L-2-Hydroxyglutaric acid disodium ((S)-2-Hydroxyglutaric acid disodium, L-2-Hydroxyglutarate disodium, LGA, L-2HG) 是一种表观遗传修饰剂和在肾脏癌中推测的肿瘤代谢物，抑制 histone demethylases，因此促进组蛋白甲基化。L-2-Hydroxyglutaric acid disodium 也是一种 mitochondrial creatine kinase (Mi-CK) 的抑制剂，对应的Km值和Ki值分别为2.52 mM和11.13 mM。
SJ-MX1196	CTPI-2		CTPI-2 是第三代特异性线粒体柠檬酸盐载体 SLC25A1 抑制剂，KD 为 3.5 μM。CTPI-2 抑制糖酵解、PPARγ 及其下游靶点葡萄糖转运蛋白 GLUT4。CTPI-2 阻断非酒精性脂肪性肝炎逆转脂肪变性的显著改变，防止演变为脂肪性肝炎，减少肝脏和脂肪组织中炎性巨噬细胞的浸润，并显著减轻由高脂肪饮食引起的肥胖。具有抗肿瘤活性。
SJ-MN0514	Glyburide (Glibenclamide)	格列本脲	Glyburide (Glibenclamide)是一种具有口服活性的 ATP 敏感的 K⁺ 通道 (K_ATP) 抑制剂，可用于糖尿病和肥胖的研究。Glyburide抑制 P-glycoprotein。Glyburide直接结合并阻断K_ATP 的 SUR1 亚基并抑制囊性纤维化跨膜传导调节蛋白 (CFTR)。Glibenclamid 可诱导自噬（autophagy）。
SJ-MN0572	L-Hisidine	L-组氨酸	L-Histidine是婴儿必需的氨基酸。L-Histidine是线粒体谷氨酰胺转运的抑制剂。