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Liver X Receptor (LXR)

Liver X Receptor (LXR)相关产品(13)
货号 产品名 中文名称 产品描述
SJ-MN0429 Saikosaponin A 柴胡皂苷 A

Saikosaponin A 是一种三萜皂苷,是药用植物银柴胡中的主要活性成分,可上调 LXRα 的表达,具有有效抗炎、免疫调节和抗菌活性。

SJ-MX2433 RGX-104 hydrochloride RGX-104 hydrochloride 是一种小分子 LXR 激动剂,通过 ApoE 基因的转录激活调节先天免疫。
SJ-MX1378 LXR-623 (WAY-252623) LXR-623是可以渗透血脑屏障的 LXRα部分激动剂和 LXRβ完全激动剂,IC50 分别为24 nM 和 179 nM。
SJ-MN0314 (20S)-Protopanaxatriol 20 (S)-原人参三醇

(20S)-Protopanaxatriol 是人参皂苷的代谢物,具有神经保护活性,它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体,具有广泛的抗癌活性,可调节内皮细胞功能。

SJ-MX3546 SR9243 SR9243 is a potent , cell-permeable and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. It induces cell death in multiple types of cancer and does not cause the side effects that have derailed previous attempts to target these processes.
SJ-MN0777 Yamogenin 雅姆皂甙元 Neodiosgenin is bioactive compound.
SJ-MX3864 AZ876 AZ-876 is a novel, potent high-affinity agonist of Liver X Receptor (LXR) with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively. AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects.
SJ-MX3932 SR9238 SR9238 is a selective inverse agonist of LXRα and LXRβ with IC50 values of 214 and 43 nM, respectively.
SJ-MX3981 Abequolixron Abequolixron (SB742881; RG104; SB-742881) is a novel potent and orally bioavailable liver-X nuclear hormone receptor-beta (LXR) agonist with potential immunomodulating and anticancer activities. It modulates innate immunity via transcriptional activation of the ApoE gene.
SJ-MX4617 27-Hydroxycholesterol 27-羟基胆固醇 27-Hydroxycholesterol (27-HC) is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR).
SJ-MX0712 T0901317

TT0901317 是一种有效的,选择性的性肝 X 受体 (LXR)和FXR激动剂,对 LXRα 和FXR的EC50分别约为20 nM和5 μM。T0901317 是 RORα 和 RORγ 的双重反向激动剂,对应的Ki值分别为132 nM和51 nM。T0901317 可显着抑制细胞增殖并诱导凋亡 (apoptosis),并抑制低密度脂蛋白 (LDL) 受体缺失小鼠动脉粥样硬化的发展。

SJ-MX0753 GW3965 hydrochloride

GW3965 hydrochloride 是一种有效的,选择性肝 X 受体 (LXR) 激动剂,作用于hLXRα和hLXRβ,无细胞试验中EC50分别为190和30 nM。

SJ-MX4017 GSK2033

GSK2033 是一种 LXR 拮抗剂,对于 LXRα和 LXRβ的 pIC50 值分别为 7 和 7.4。