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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MX3546 | SR9243 | SR9243 is a potent , cell-permeable and selective LXR inverse agonist. SR9243 kills cancer cells by inhibiting lipid production and the Warburg effect. It induces cell death in multiple types of cancer and does not cause the side effects that have derailed previous attempts to target these processes. | |
| SJ-MX0712 | T0901317 |
TT0901317 是一种有效的，选择性的性肝 X 受体 (LXR)和FXR激动剂，对 LXRα 和FXR的EC50分别约为20 nM和5 μM。T0901317 是 RORα 和 RORγ 的双重反向激动剂，对应的Ki值分别为132 nM和51 nM。T0901317 可显着抑制细胞增殖并诱导凋亡 (apoptosis)，并抑制低密度脂蛋白 (LDL) 受体缺失小鼠动脉粥样硬化的发展。 |
|
| SJ-MX0753 | GW3965 hydrochloride |
GW3965 hydrochloride 是一种有效的，选择性肝 X 受体 (LXR) 激动剂，作用于hLXRα和hLXRβ，无细胞试验中EC50分别为190和30 nM。 |
|
| SJ-MN0314 | (20S)-Protopanaxatriol | 20 (S)-原人参三醇 |
(20S)-Protopanaxatriol 是人参皂苷的代谢物，具有神经保护活性，它是糖皮质激素受体GR和雌激素受体ERbeta的功能性配体，具有广泛的抗癌活性，可调节内皮细胞功能。 |
| SJ-MX4617 | 27-Hydroxycholesterol | 27-羟基胆固醇 | 27-Hydroxycholesterol (27-HC) is an endogenous oxysterol with multiple biological functions, including activity as a selective estrogen receptor modulator (SERM) (a mixed, tissue-specific agonist-antagonist of the estrogen receptor (ER)) and as an agonist of the liver X receptor (LXR). |
| SJ-MN0429 | Saikosaponin A | 柴胡皂苷 A | Saikosaponin A 是从银柴胡中的主要活性成分，可上调 LXRα 的表达，具有有效抗炎活性。 |
| SJ-MX2433 | RGX-104 hydrochloride | RGX-104 hydrochloride 是一种小分子 LXR 激动剂，通过 ApoE 基因的转录激活调节先天免疫。 | |
| SJ-MX1378 | LXR-623 (WAY-252623) | LXR-623是可以渗透血脑屏障的 LXRα部分激动剂和 LXRβ完全激动剂，IC50 分别为24 nM 和 179 nM。 | |
| SJ-MN0777 | Yamogenin | 雅姆皂甙元 | Neodiosgenin is bioactive compound. |
| SJ-MX3864 | AZ876 | AZ-876 is a novel, potent high-affinity agonist of Liver X Receptor (LXR) with Ki values of 0.007 μM and 0.011 μM for human LXRα and LXRβ respectively. AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects. | |
| SJ-MX3932 | SR9238 | SR9238 is a selective inverse agonist of LXRα and LXRβ with IC50 values of 214 and 43 nM, respectively. | |
| SJ-MX3981 | Abequolixron | Abequolixron (SB742881; RG104; SB-742881) is a novel potent and orally bioavailable liver-X nuclear hormone receptor-beta (LXR) agonist with potential immunomodulating and anticancer activities. It modulates innate immunity via transcriptional activation of the ApoE gene. | |
| SJ-MX4017 | GSK2033 | GSK2033 is the first potent cell-active LXR antagonist (IC50 value 31.6 nM for LXRβ binding). |
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