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Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog Nur77 p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) Nucleoside Antimetabolite/AnalogOrthopoxvirus ROCK ATF6 Haspin Kinase Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Endocrinology/Hormones

Adrenergic Receptor Androgen Receptor Angiotensin-converting Enzyme (ACE) Aromatase Cholecystokinin Receptor TSH Receptor Estrogen Receptor/ERR GHSR Glucocorticoid Receptor GNRH Receptor Mineralocorticoid Receptor Opioid Receptor PGD synthase PGE synthase Progesterone Receptor Thyroid Hormone Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain FTO HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR27 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor E3 Ligase Ligand-Linker Conjugates RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Vasopressin Receptor

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Indoleamine 2,3-Dioxygenase (IDO)

Indoleamine 2,3-Dioxygenase (IDO)相关产品（16）

货号	产品名	中文名称	产品描述
SJ-MX3294	PF-06840003 (EOS200271)		PF-06840003 (EOS200271) is a highly selective orally bioavailable indoleamine 2,3-dioxygenase -1 (IDO-1) inhibitor (IC50 = 0.15 μM for human enzyme). It inhibits IDO-1-mediated production of kynurenine induced by IFN-γ in HeLa cells (IC50 = 1.8 µM) and by LPS and IFN-γ in THP-1 cells and human-derived whole blood ex vivo (IC50s = 1.7 and 4.7 µM, respectively).
SJ-MX2527	IDO-IN-1		IDO-IN-1 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50 为 59 nM。
SJ-MX1049	PCC0208009		PCC0208009是IDO有效的抑制剂，其在HeLa细胞中的IC50值为4.52 nM。PCC0208009通过调节ACC和杳仁核的突触可塑性来减轻神经性疼痛和合并症。
SJ-MX2950	IDO5L		IDO5L is a potent IDO1 inhibitor that displays IC50 values of 67 and 19 nM for human IDO in enzymatic activity and HeLa cell assays, respectively. It is inactive against tryptophan 2,3-dioxygenase (IC50 > 10 µM).
SJ-MN1141	Coptisine	黄连碱	Coptisine 是从黄连中分离到的生物碱，是一种有效的非竞争性的 IDO 抑制剂，Ki 值为 5.8 mM，IC50 值为 6.3 mM。
SJ-MN0128	Palmatine hydrochloride	盐酸巴马汀/盐酸掌叶防己碱	Palmatine chloride 是一种口服活性的不可逆 IDO-1 抑制剂。 Palmatine chloride 可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善 DSS 诱发的结肠炎。
SJ-MN1222	(S)-Indoximod	相思子碱	(S)-Indoximod (1-Methyl-L-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂。(S)-Indoximod 可用于癌症研究。
SJ-MX0253	Necrostatin-1		Necrostatin-1 (Nec-1) 是一种是一种可渗透细胞的、有效的、选择性的坏死性凋亡 (necroptosis) 抑制剂，Necrostatin-1 也是死亡域受体相关适配器激酶RIP1的选择性变构抑制剂，EC50=182 nM。Necrostatin-1也可抑制Indoleamine 2，3-Dioxygenase (IDO)、细胞自噬（autophagy）和凋亡（apoptosis）。
SJ-MX3863	GNF-PF-3777		GNF-PF-3777 (8-Nitrotryptanthrin) is a potent selective inhibitor of the human indoleamine 2,3-dioxygenase 2 (hIDO2) which dramatically reduces IDO2 activity with Ki value of 0.97 μM.
SJ-MX0957	Linrodostat (BMS-986205)		Linrodostat (BMS-986205, ONO-7701)是一种选择性的、不可逆的吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂，IC50为1.7 nM，对IDO2或TDO没有太大影响。它能抑制犬尿氨酸的生成，在人源Hela细胞、表达人源IDO-1的HEK293细胞和表达TDO的HEK293细胞中，IC50分别为1.7、1.1和>2000 nM。Linrodostat (BMS-986205) 在晚期癌症中具有良好的药理活性。
SJ-MX0221	Epacadostat (INCB024360)	艾卡哚司他	Epacadostat (INCB024360)是在小鼠黑色素瘤模型中具有体内药效活性和功效的吲哚胺 2，3-双加氧酶的强竞争性抑制剂（IDO1，体外 IC50 值为 72 nM）；Epacadostat (INCB024360) 将血浆中犬尿氨酸水平降低 >50%，并以剂量依赖性方式抑制 B16-GM-CSF 肿瘤生长。
SJ-MX1022	IDO-IN-2		IDO-IN-2 (RG 6078, NLG-919 analogue, GDC-0919 analogue)是一种有效的 (indoleamine2,3-dioxygenase1, IDO1) 通路抑制剂，IC50值 of 38 nM。
SJ-MX2430	Indoximod		Indoximod (1-Methyl-D-tryptophan; NLG-8189) 是吲哚胺2，3-双加氧酶 (IDO) 通路抑制剂，Ki 为19 μM。
SJ-MN0128A	Palmatine	黄藤素，巴马汀	Palmatine 是一种口服活性的不可逆 IDO-1 抑制剂。Palmatine 可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。Palmatine 有潜力用于结肠炎的研究。
SJ-MN0558	Coptisine chloride	盐酸黄连碱	Coptisine chloride 是从黄连中分离到的生物碱，是一种有效的非竞争性的 IDO 抑制剂，Ki 值为 5.8 μM，IC50 值为 6.3 μM。Coptisine chloride 是一种有效的 H1N1 神经氨酸酶 (NA-1) 抑制剂，IC50 为 104.6 μg/mL，可用于甲型流感病毒 (H1N1) 感染。
SJ-MX5634	Navoximod