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Anti-infection

Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease
Apoptosis

Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD
Autophagy

Autophagy FKBP LRRK2 Mitophagy OGA ULK
Cell Cycle/DNA Damage

Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog Nur77 p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) Nucleoside Antimetabolite/AnalogOrthopoxvirus ROCK ATF6 Haspin Kinase Sirtuin SRPK Telomerase TOPK Topoisomerase Wee1
Cytoskeletal Signaling

Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
Endocrinology/Hormones

Adrenergic Receptor Androgen Receptor Angiotensin-converting Enzyme (ACE) Aromatase Cholecystokinin Receptor TSH Receptor Estrogen Receptor/ERR GHSR Glucocorticoid Receptor GNRH Receptor Mineralocorticoid Receptor Opioid Receptor PGD synthase PGE synthase Progesterone Receptor Thyroid Hormone Receptor
Epigenetics

AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain FTO HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin
GPCR/G Protein

5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPCR19 GPR109A GPR119 GPR120 GPR139 GPR27 GPR40 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor E3 Ligase Ligand-Linker Conjugates RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Vasopressin Receptor

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Cytochrome P450

Cytochrome P450相关产品（79）

货号	产品名	中文名称	产品描述
SJ-MX0675	Memantine hydrochloride	盐酸美金刚	Memantine hydrochloride (D-145 hydrochloride) 是一种温和的 NMDA 受体 (NMDA receptor) 非竞争性拮抗剂，（体外IC50 = 0.5 ~ 1.5 μM），与离子通道位点结合。 Memantine hydrochloride 还能够抑制 CYP2B6 和 CYP2D6，Ki值分别为0.51 μM和84.4 μM。
SJ-MX0897	Verapamil hydrochloride	盐酸维拉帕米	Verapamil hydrochloride (CP-16533-1 hydrochloride) 是一种L-型钙通道 (calcium channel) 阻滞剂，可抑制正常心脏组织以及房室和窦房结中钙的缓慢向内流动。Verapamil hydrochloride是一种有效的口服活性的第一代 P 糖蛋白 (permeability-glycoprotein，P-gp) 抑制剂。Verapamil hydrochloride 能也抑制 CYP3A4，并可用于高血压，心律不齐和心绞痛的研究。
SJ-MX0968A	Abiraterone Acetate	乙酸阿比特龙酯	Abiraterone Acetate是一种口服、有效、选择性和不可逆的甾体类CYP17A1 抑制剂。Abiraterone Acetate是Abiraterone前药，具有抗雄激素活性。Abiraterone acetateis 是一种口服的雄性激素 androgen 生物合成抑制剂。
SJ-MX0968B	Abiraterone	阿比特龙	Abiraterone是一种口服、有效、选择性和不可逆的甾体类CYP17A1 抑制剂，具有抗雄激素活性。Abiraterone抑制细胞色素 p450 酶 CYP17 的 17α-羟化酶（17α-hydroxylase）和 17,20-裂合酶（17，20-lyase ）活性，IC50 值分别为 2.5 nM 和 15 nM。
SJ-MX3603	Orteronel (TAK-700)		Orteronel (TAK-700) is a potent, orally available, and highly selective inhibitor of 17,20-lyase (CYP17A1; IC50 value 19 nM and 48 nM for human and rat respectively) and of correlated androgen synthesis. TAK 700 exhibits no affinity for CYP11B 1and CYP3A4 (IC50 values >1000 nM and >10000 nM resp.), nor for other isoforms of the human CYP enzyme (IC50 values >14000 nM). When given orally to monkeys at a dose of 1 mg/kg, TAK 700 markedly reduced serum testosterone and DHEA at 5 h after administration.TAK 700 was selected for evaluation in patients in phase III clinical trials for the potential treatment of prostate cancer.
SJ-MX1200	DMU2139		DMU2139 is a potent and specific CYP1B1 inhibitor, with IC50s of 9 nM and 795 nM for CYP1B1 and CYP1A1, respectively.
SJ-MX2993	APD668		APD668 is a potent and selective, orally active G protein-coupled receptor 119 agonist (EC50 values 2.7 nM and 23 nM for hGPR119 and rGPR119, respectively) with in vivo activity in rodent models of glucose control. APD 668 significantly improved blood glucose handling during glucose challenge in several diabetic and non-diabetic rodent models, showing a clear glucose-dependent effect on insulin release in a hyperglycemic clamp model in the Sprague–Dawley rat. APD 668 is not genotoxic, and shows no significant inhibition of any of the five major CYP isoforms with the exception of CYP2C9 (Ki value 0.1 μM).
SJ-MX2513	Atovaquone	阿托伐醌	Atovaquone (Atavaquone) is a broad-spectrum antiprotozoal agent that is active against Plasmodium, Toxoplasma, and Babesia, among other protozoa. It inhibits complex III activity on dihydroorotate in isolated P. falciparum and P. yoelii mitochondria more potently than in rat liver mitochondria (EC50s = 0.95, 0.94, and 510 nM, respectively) and depolarizes the mitochondrial membrane in P. yoelii-infected mouse erythrocytes (EC50 = 260 nM). Atovaquone also inhibits transport mediated by human breast cancer resistance protein (BCRP) and P-glycoprotein in membrane vesicles (IC50s = 0.23 and 6.8 μM, respectively.
SJ-MX2566	Clomethiazole	氯美噻唑	Clomethiazole is a positive allosteric modulator at the barbiturate/picrotoxin site of the GABAA receptor. It acts as a sedative and hypnotic agent.
SJ-MX1622	1-Aminobenzotriazole	1-氨基苯并三唑	1-Aminobenzotriazole 是细胞色素 P450 (P450) 的非特异且不可逆抑制剂。
SJ-MX1599	Brassinazole	芸苔素唑；(Rac)-芸苔素唑； (Rac)-油菜素唑	(Rac)-Brassinazole 是三唑型化合物，是油菜素甾醇 (BR) 生物合成抑制剂。(Rac)-Brassinazole 增加 CYP90B 在 BR 生物合成中的抑制作用。
SJ-MX2526	Bergaptol		Bergaptol is a novel and potent skin-photosensitizing hydroxyfurocoumarin.
SJ-MX2564	Clobetasol propionate	丙酸氯倍他索	Clobetasol propionate (formerly CGP-9555, CCl-4725; CGP9555; CCl4725; Clobex Cosvate; Temovate; Olux Tenovate) is a topical corticosteroid used as an anti-inflammatory for treatment of various skin disorders including eczema and psoriasis.
SJ-MX2590	Doxepin hydrochloride	盐酸多塞平	Doxepin hydrochloride is a highly potent Histamine H1 Receptor (histamine H1) antagonist. Doxepin hydrochloride also binds to histamine H4 receptor. Doxepin hydrochloride is an inhibitor of AR and mAChR. Doxepin hydrochloride is a dibenzoxepin analogue and tricyclic antidepressant with antipruritic and sedative activities. Doxepin also has antagonistic effects on histamine (H1 and H2), 5-HT2, alpha-1 adrenergic, and muscarinic receptors. The antipruritic effect of this agent is the result mediated through inhibition of histamine receptors.
SJ-MX2593	1-Ethynylnaphthalene	1-乙炔萘；1-乙炔基萘	1-Ethynylnaphthalene 是细胞色素 P450 1B1 的选择性抑制剂。
SJ-MX2653	Metyrapone	美替拉酮	Metyrapone is a drug used in the diagnosis of adrenal insufficiency and occasionally in the treatment of Cushing's syndrome (hypercortisolism). It blocks cortisol synthesis by reversibly inhibiting steroid 11β-hydroxylase. This stimulates ACTH secretion, which in turn increases plasma 11-deoxycortisol levels.
SJ-MX2697	Proadifen hydrochloride		Proadifen hydrochloride is an inhibitor of drug metabolism and CYTOCHROME P-450 ENZYME SYSTEM activity.
SJ-MX2728	Ticlopidine		Ticlopidine (PCR 5332) 是一种抗血栓前药，作为非竞争性的变构 CD39 抑制剂，IC50 为 81.7 µM。Ticlopidine 阻断 NTPDase 同工酶，对 NTPDase2 和 NTPDase3 的 IC50 分别为 170 µM 和 149 µM。Ticlopidine 是 CYP2C19 人肝细胞色素的抑制剂。Ticlopidine 抑制 CYP2C9 和 CYP3A4，IC50 值分别为 26.0 和 32.3 µM。
SJ-MX3286	Gemfibrozil	吉非罗齐	吉非罗齐（Pilder；CI-719；CI719；Lopid；Jezil; Lipur；Trialmin）是一种有效的抗高甘油三酯/降脂药物，作为过氧化物增殖激活受体-α（PPARα）的激活剂/拮抗剂。它已被批准用于治疗高胆固醇血症和高甘油三酯血症。
SJ-MX1105	TMS		TMS ((E)-2，3'，4，5'-tetramethoxystilbene) 是一种选择性和竞争性 CYP1B1 抑制剂，IC50 为 6 nM，Ki 值为 3 nM。TMS 对 CYP1A1 (IC50=300 nM) 和 CYP1A2 (IC50=3.1 μM) 的抑制作用较小。TMS 是白藜芦醇的甲基化衍生物，具有抗癌活性。