货号 | 产品名 | 中文名称 | 产品描述 |
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SJ-MX0495 | Aloxistatin (E64d) | 阿洛司他丁 |
Aloxistatin (E64d) 是一种不可逆的膜透过性广谱半胱氨酸蛋白酶 (cysteine protease) 抑制剂,它抑制完整溶酶体和细胞中的组织蛋白酶 B 和 L,具有抑制血小板聚集的活性。Aloxistatin (E64d) 可以抑制 MERS-CoV 和 SARS-CoV-2 病毒颗粒的细胞入侵。 |
SJ-BP0037 | E-64 | E-64 (Proteinase inhibitor E 64) 是一种有效的不可逆的半胱氨酸蛋白酶 (cysteine proteases) 抑制剂,抑制 papain 的 IC50 为 9 nM。 | |
SJ-MX3527 | LY 3000328 | LY 3000328(LY3000328) is a novel, potent and selective Cathepsin S (Cat S) inhibitor with IC50s of 7.7 and 1.67 nM for hCat S and mCat S, respectively. It has excellent in vitro potency and selectivity against other cysteine proteases. LY3000328 is currently in clinical trials. Cathepsin S (Cat S) plays an important role in many pathological conditions, including abdominal aortic aneurysm (AAA). Inhibition of Cat S may provide a new treatment for AAA. | |
SJ-MX2548 | Balicatib | 巴利卡替 | Balicatib (AAE-581) is a potent human cathepsin K inhibitor in vitro (IC50 = 1.4 nM) with a high selectivity against human cathepsins B, L, and S (> 4,800-fold, > 500-fold and > 65,000-fold, respectively). |
SJ-MX2470 | PMSF | 苯甲基磺酰氟 | PMSF是通常用于制备细胞裂解物的不可逆的丝氨酸/半胱氨酸蛋白酶抑制剂。 |
SJ-MX1703 | Cathepsin Inhibitor 1 | 组织蛋白酶抑制剂1 | Cathepsin Inhibitor 1抑制剂1 是一种Cathepsin (L, L2, S, K, B)的抑制剂, pIC50 分别为7.9, 6.7, 6.0, 5.5, 5.2。 |
SJ-MX1904 | NSC 185058 | NSC 185058 是一种 ATG4B 抑制剂。ATG4B 是一种主要的半胱氨酸蛋白酶 (cysteine protease)。NSC185058 抑制 ATG4B 从而显著减弱自噬 (autophagic) 活性。 | |
SJ-MX4091 | CA-074 | CA-074 is a potent and selective inhibitor of cathepsin B. | |
SJ-MX0584 | CA-074 methyl ester | CA-074 methyl ester 是一种特异性的 Cathepsin B 抑制剂,具有保护神经,抗癌、抗炎等多种生物活性。 | |
SJ-MX0812 | Odanacatib (MK-0822) | 奥当卡替 |
Odanacatib (MK-0822) 是有效,选择性的人/兔组织蛋白酶K(cathepsin K)抑制剂,IC50 分别为0.2 nM 和 1 nM,对脱靶的cathepsin B, L, S具有高度选择性。 |
SJ-MX0984 | Calpeptin |
Calpeptin 是一种有效的、具有细胞穿透性的 calpain 抑制剂,其对人血小板 Calpain I 的 ID50 值为 40 nM。Calpeptin 也是 cathepsin K 的抑制剂。 |
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SJ-MX1014 | E 64c | 阿洛司他丁酸 | E 64c 是半胱氨酸蛋白酶 (cysteine proteases) 天然环氧化物抑制剂的衍生物,也是钙离子激活中性蛋白酶 (CANP) 的抑制剂和组织蛋白酶C (cathepsin C) 的弱不可逆抑制剂。E 64c 可抑制 MERS-CoV. |
SJ-BP0095 | Leupeptin hemisulfate | 亮肽素 | Leupeptin hemisulfate is a microbial product. A reversible inhibitor of serine and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B. |
SJ-BP0119 | Z-FA-FMK |
Z-FA-FMK ((1S)-Z-FA-FMK; Compound 6) 是一种广谱的卤代甲基酮抑制剂,可抑制冠状病毒 (SARS-CoV) 蛋白酶 3CL,Ki 为 25.7 μM。Z-FA-FMK ((1S)-Z-FA-FMK) 是一种有效的组织蛋白酶 B 和 L 抑制剂。Z-FA-FMK 通过选择性合成类维生素 a 相关分子 (RRMs) 阻断 DEVDase 活性、DNA 片段化和磷脂酰丝氨酸外化的诱导。Z-FA-FMK 抑制细胞凋亡 (apoptosis)。Z-FA-FMK 可抑制 caspase 活性,并选择性抑制重组效应蛋白 caspase 2、-3、-6 和 -7。 |
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SJ-MX0596 | N-Ethylmaleimide (NEM) | N-乙基顺丁烯二酰亚胺 |
Ethylmaleimide (NEM) 衍生于马来酸,是一种不可逆的 半胱氨酸蛋白酶(cysteine peptidases)抑制剂,在活性位点硫醇基发生烷化。N-Ethylmaleimide 特异的抑制线粒体中的磷酸盐转运。N-Ethylmaleimid 对脯氨酰内肽酶有抑制作用,其 IC50 值为6.3 μM。N-Ethylmaleimide 同样也是一种去泛素化酶 (deubiquitinating enzyme,DUB) 抑制剂。 |
SJ-MX4308 | 2-Cyanopyrimidine | 2-Cyanopyrimidine is a cathepsin K inhibitor. Cathepsin K is a protease defined by its high specificity for kinins, which is involved in bone resorption.Enzymatic study showed that 2-cyano-Pyrimidine had an IC50 value of 170 nM for inhibition of cathepsin K, elevated activity of which has been linked to the formation of osteoporosis and arthritis. | |
SJ-MX5635 | Cathepsin G Inhibitor I |