Glucokinase

货号	产品名	中文名称	产品描述
SJ-MX3723	AMG-3969		AMG-3969 is a GK-GKRP disruptor. AMG-3969 normalized blood glucose levels in several rodent models of diabetes. AMG-3969 potently reversed the inhibitory effect of GKRP on GK activity and promoted GK translocation both in vitro (isolated hepatocytes) and in vivo (liver). AMG-3969 blood glucose lowering was restricted to diabetic and not normoglycaemic animals.
SJ-MX3862	AM-2394		AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models.
SJ-MX4557	Globalagliatin		Globalagliatin (LY2608204) 是一种新型有效的葡糖激酶(GK)激活剂,EC50值为42 nM。
SJ-MX1633	Dorzagliatin	多扎格列汀	Dorzagliatin (HMS5552) 是一种双重作用的葡萄糖激酶 (glucokinase; GK) 激活剂，可改善 2 型糖尿病的血糖控制和胰腺β细胞功能。