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| 货号 | 产品名 | 中文名称 | 产品描述 |
|---|---|---|---|
| SJ-MX0795 | Acetazolamide | 乙酰唑胺 |
Acetazolamide (Diamox) 是一种碳酸酐酶 (carbonic anhydrase，CA) IX 抑制剂，抑制 hCA IX，IC50 为 30 nM。Acetazolamide的利尿作用是有限的，目前主要用于治疗青光眼。 |
| SJ-MX2581 | Dichlorphenamide | 二氯苯二磺胺 | Dichlorphenamide is a potent, orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye. Used in the treatment of glaucoma and primary periodic paralysis. |
| SJ-MH0037 | Fluorometholone acetate | 氟米龙醋酸酯 | Fluorometholone Acetate (formerly NSC47438; NSC-47438; U 17,323; AI 3-52814; Flarex) is a synthetic corticosteroid that has been approved as a medication commonly used as eye drops in the treatment of steroid responsive inflammatory conditions of the eye. |
| SJ-MX2485 | Tioxolone | 噻克索酮 | Tioxolone (Thioxolone) is a potent inhibitor of metalloenzyme carbonic anhydrase I with a variety of activities such as cytostatic, antipsoriatic, anti-acne, antibacterial and anti-mycotic properties. It inhibits carbonic anhydrase I with a Ki of 91 NM. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties. |
| SJ-MX2532 | Brinzolamide | 布林佐胺 | Brinzolamide (AL-4862; AL4862; Azopt, Alcon Laboratories, Befardin, AL4862) is a highly potent and selective CAI (carbonic anhydrase II inhibitor) with anti-hypertensive activity. It inhibits carbonic anhydrase II with an IC50 of 3.19 nM. Brinzolamide is used to treat glaucoma (open angle-type) or other eye diseases (e.g. ocular hypertension). |
| SJ-MX2650 | Methazolamide | 醋甲唑胺 | Methazolamide is a potent carbonic anhydrase (CA) inhibitor (IC50 = 130 nM) with anti-glaucoma, anti-diabetic, and potential anti-neoplastic activity. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma. |
| SJ-MX3337 | 2-Aminobenzenesulfonamide | 2-Aminobenzenesulfonamide 是碳酸酐酶 IX (carbonic anhydrase IX) 的抑制剂。 | |
| SJ-MX1211 | U-104 (SLC-0111) | U-104 (SLC-0111) 是一种有效的 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂，Ki 值分别为 45.1 nM 和 4.5 nM。U-104 在小鼠模型中显示出明显的肿瘤生长延迟。 | |
| SJ-MX1296 | Zonisamide | 唑尼沙胺 | Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的抑制剂，对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性。Zonisamide 可用于癫痫、癫痫发作和帕金森病的研究。 |
| SJ-MX2232 | Dorzolamide hydrochloride | 盐酸多佐胺 | Dorzolamide (L671152) hydrochloride 是有效的碳酸酐酶 carbonic anhydrase II 的抑制剂，其对红细胞CA-II 和CA-I 的 IC50 值分别为 0.18 nM 和 600 nM。 |
| SJ-MX3687 | Indisulam | Indisulam (E 7070) 是一种碳酸酐酶抑制剂，具有抗癌活性。Indisulam (E 7070) 是细胞周期 G1 期的靶向化合物。Indisulam (E 7070) 通过抑制 CDK2 和周期蛋白 E 的激活，引起 G1/S 转化被阻滞。Indisulam (E 7070) 通过募集 DCAF15 诱导 RBM39 降解来靶向剪接。 | |
| SJ-MX1294 | Topiramate | 托吡酯 | Topiramate (McN 4853) 是一种广谱抗癫痫药。Topiramate 也是一种 GluR5 受体拮抗剂，可通过增强 GABAergic 活性，抑制 kainate/AMPA 受体，抑制钠和钙通道的电压敏感，增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。 |
| SJ-MX5061 | EMAC10101d | ||
| SJ-MX5173 | Benzolamide | ||
| SJ-MX5554 | Polmacoxib |
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