信号通路

• Anti-infection
  Antibiotic Arenavirus Bacterial CMV Enterovirus Filovirus Fungal HBV HCV HCV Protease HIV HIV Integrase HIV Protease HSV Influenza Virus Orthopoxvirus Parasite TMV Reverse Transcriptase RSV SARS-CoV Virus Protease
• Apoptosis
  Apoptosis Bcl-2 Family Caspase c-Myc Ferroptosis FKBP IAP Family MDM-2/p53 PKD Necroptosis Pyroptosis RIP kinase Thymidylate Synthase TNF Receptor TRADD Cuproptosis
• Autophagy
  Autophagy FKBP LRRK2 Mitophagy OGA ULK
• Cell Cycle/DNA Damage
  Antifolate APC ATM/ATR Aurora Kinase BMI-1 Casein Kinase CDK Checkpoint Kinase (Chk) CRISPR/Cas9 Deubiquitinase DNA Alkylator/Crosslinker DNA/RNA Synthesis DNA-PK Early 2 Factor (E2F) Eukaryotic Initiation Factor (eIF) GAK G-quadruplex HDAC HSP IRE1 Kinesin LIM Kinase (LIMK) Microtubule/Tubulin Mps1 DNA Stain Nucleoside Antimetabolite/Analog Nur77 p97 PAK PARP PERK Polo-like Kinase (PLK) PPAR RAD51 Cyclin G-associated Kinase (GAK) ROCK ATF6 Haspin Kinase Sirtuin SRPK PDI Telomerase TOPK Topoisomerase Wee1
• Cytoskeletal Signaling
  Arp2/3 Complex Dynamin Gap Junction Protein Integrin Kinesin Microtubule/Tubulin Mps1 Myosin PAK ROCK
• Endocrinology/Hormones
  Adrenergic Receptor Androgen Receptor Angiotensin-converting Enzyme (ACE) Aromatase Cholecystokinin Receptor TSH Receptor Estrogen Receptor/ERR GHSR Glucocorticoid Receptor GNRH Receptor Mineralocorticoid Receptor Opioid Receptor PGD synthase PGE synthase Progesterone Receptor Thyroid Hormone Receptor
• Epigenetics
  AMPK Aurora Kinase DNA Methyltransferase Epigenetic Reader Domain HDAC Histone Acetyltransferase Histone Demethylase Histone Methyltransferase MicroRNA PARP PKC Protein Arginine Deiminase Methionine Adenosyltransferase (MAT) Sirtuin JAK
• GPCR/G Protein
  5-HT Receptor Adenosine Receptor Adenylate Cyclase (AC) Adiponectin Receptor Adrenergic Receptor Angiotensin Receptor Bombesin Receptor Bradykinin Receptor Cannabinoid Receptor CaSR CCR CGRP Receptor Cholecystokinin Receptor CRFR CXCR TSH Receptor Neuropeptide Y Receptor Dopamine Receptor EBI2/GPR183 Endothelin Receptor Formyl peptide receptor (FPR) GHSR Glucagon Receptor Glucocorticoid Receptor GNRH Receptor GPR109A GPR119 GPR139 GPR27 GPR55 GPR84 Guanylate Cyclase Histamine Receptor Imidazoline Receptor Leukotriene Receptor LPL Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Neurokinin Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Oxytocin Receptor P2Y Receptor PKG Prostaglandin Receptor Protease-Activated Receptor (PAR) Apelin Receptor (APJ) Ras GPR88 Free Fatty Acid Receptor E3 Ligase Ligand-Linker Conjugates RGS GPR4 Secretin Receptor Mas-related G-protein-coupled Receptor (MRGPR) GPR35 GPR52 MCHR1 (GPR24) Leukotriene Receptor GLP Receptor Somatostatin Receptor Arrestin Platelet-activating Factor Receptor (PAFR) Mas-related G-protein-coupled Receptor (MRGPR) Kisspeptin Receptor G Protein-coupled Receptor Kinase (GRK) G protein-coupled Bile Acid Receptor 1 Succinate Receptor 1 Protease Activated Receptor (PAR) Vasopressin Receptor

• Immunology/Inflammation
  Arginase Aryl Hydrocarbon Receptor (AhR) CCR CD markers Complement System COX CXCR Cyclic GMP-AMP Synthase (cGAS) TIM-3 TIGIT CTLA-4 FKBP FLAP Galectin IFNAR Interleukin Related IRAK MIF MyD88 NO Synthase NOD-like Receptor (NLR) PD-1/PD-L1 PGE synthase CX3CR1 Pyroptosis Nuclear Factor of activated T Cells (NFAT) Reactive Oxygen Species AP-1 CD28 Salt-inducible Kinase (SIK) SOD CD73 SPHK STING Thrombopoietin Receptor Toll-like Receptor (TLR) AP-1
• JAK/STAT Signaling
  EGFR HER2 HER3 HER4 JAK Pim STAT
• MAPK Signaling Pathway
  ERK JNK KLF MAP3K MAP4K MEK Mixed Lineage Kinase MNK p38 MAPK Raf Ribosomal S6 Kinase (RSK) MAPKAPK2 (MK2)
• Membrane Transporter/Ion Channel
  Amino acid transporter Aquaporin (AQP) ATP synthase ATPase BCRP Calcium Channel CD markers CFTR Chloride Channel CRAC Channel CRM1 iGluR URAT1 Piezo Channel GABA Receptor GLUT GlyT Mechanosensitive channels (MSCs) Monoamine Transporter (MAT) Monocarboxylate Transporter (MCT) Na+/Ca2+ Exchanger Na+/HCO3- Cotransporter nAChR NKCC P2X Receptor P-glycoprotein Potassium Channel Proton Pump EAAT HCN Channel SGLT Sodium Channel Apical Sodium-Dependent Bile Acid Transporter TRP Channel Na+/K+ ATPase Organic Anion Transporting Polypeptide (OATP) VDAC
• Metabolic Enzyme/Protease
  5α-reductase Acetyl-CoA carboxylase Acyltransferase Adenosine Deaminase Adenosine Kinase Aldose Reductase Aminoacyl-tRNA Synthetase Aminopeptidase Angiotensin-converting Enzyme (ACE) Arginase ATGL ATP Citrate Lyase Carbonic Anhydrase Carboxypeptidase Cathepsin CETP COMT Cytochrome P450 Dehydrogenase Dipeptidyl Peptidase Dopamine β-hydroxylase Drug Metabolite Elastase Endogenous Metabolite Enolase Epoxide Hydrolase FAAH FABP Factor Xa Farnesyl Transferase (FTase) Fatty Acid Synthase (FASN) Fat Mass and Obesity-associated Protein (FTO) FXR Glucokinase Glucosidase Glutaminase Glutathione Peroxidase GSNOR Gutathione S-transferase Hexokinase HIF/HIF Prolyl-Hydroxylase HMG-CoA Reductase (HMGCR) HSP Indoleamine 2,3-Dioxygenase (IDO) Lipoxygenase Liver X Receptor (LXR) MAGL MALT1 Mitochondrial Metabolism MMP NADPH Oxidase NAMPT NEDD8-activating Enzyme Neprilysin PAI-1 PDHK Peroxidase PGC-1α Phosphatase Phosphatase Methylesterase (PME) Phosphodiesterase (PDE) Phospholipase poly (ADP ribose) glycohydrolase (PARG) PREP Procollagen C Proteinase Pyruvate Kinase Methionine Adenosyltransferase (MAT) 11β-HSD RAR/RXR REV-ERB Microsomal Triglyceride Transfer Protein (MTP) Reactive Oxygen Species Renin ROR Ser/Thr Protease SGK Dihydrofolate reductase (DHFR) Stearoyl-CoA desaturase (SCD) PDI Liposome FBPase Thrombin DGK Tryptophan Hydroxylase Tyrosinase Vitamin Xanthine Oxidase
• Neuronal Signaling
  5-HT Receptor Cholinesterase (ChE) Adenosine Kinase Adrenergic Receptor Calcium Channel CaMK Cannabinoid Receptor CGRP Receptor Cholecystokinin Receptor COMT iGluR Dopamine Receptor Tau Protein Dopamine Transporter FAAH GABA Receptor GlyT GPR119 GPR139 GPR55 Imidazoline Receptor mAChR Melanocortin Receptor Melatonin Receptor mGluR Monoamine Oxidase nAChR Neurokinin Receptor Neuropeptide Y Receptor Neurotensin Receptor Opioid Receptor Orexin Receptor (OX Receptor) Transthyretin (TTR) Glucosylceramide Synthase (GCS) α-synuclein AAK1 Serotonin Transporter MCHR1 (GPR24) Sigma Receptor Somatostatin Receptor Glucosylceramide Synthase (GCS) Trk Receptor TRP Channel β-Amyloid β-secretase γ-secretase
• NF-κB Signaling
  RANKL/RANK IKK Keap1-Nrf2 MALT1 NF-κB Reactive Oxygen Species
• PI3K/Akt/mTOR
  Akt AMPK ATM/ATR DNA-PK GSK-3 MELK mTOR PDK-1 PI3K PI4K PIKfyve PTEN PDPK1
• Protein Tyrosine Kinase/RTK
  Ack1 Anaplastic lymphoma kinase (ALK) Bcr-Abl BTK c-Fms c-Kit c-Met/HGFR Ephrin Receptor BMX Kinase Discoidin Domain Receptor DYRK EGFR FAK FGFR FLT3 HER2 HER3 HER4 IGF-1R Insulin Receptor ITK PDGFR PKA Pyk2 RET ROS kinase SHP2 Src Syk TAM Receptor Trk Receptor VEGFR
• Stem Cell/Wnt
  Casein Kinase ERK γ-secretase Gli GSK-3 Hedgehog Hippo (MST) LPL Receptor MAP4K NEDD8-activating Enzyme Notch Oct3/4 PKA Porcupine ROCK sFRP-1 Smo TGF-β/Smad JAK Wnt/β-catenin YAP-TEAD
• TGF-beta/Smad
  PKC ROCK TGF-β Receptor TGF-β/Smad
• Ubiquitin/Proteasome
  Deubiquitinase E1 Activating E2 conjugating E3 ligase p97 Proteasome SUMO
• Others
  Others