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Guanylate Cyclase

Guanylate Cyclase相关产品(7)
货号 产品名 中文名称 产品描述
SJ-MX2947 BAY 41-2272 BAY 41-2272 is a novel and potent activator of nitric oxide-sensitive guanylyl cyclase (NO-sensitive GC) with EC50 values of 0.3 μmol/L and 3 μmol/L in the presence and absence of 100 nmol/L DEA-NO, respectively. In platelets, GSNO at 3 μmol/L (a submaximally effective concentration) was used to assess a possible sensitizing effect of BAY 41-2272 on NO-sensitive GC. The cGMP response resulted from the application of NO at this concentration in the absence of BAY 41-2272 was only marginal. In the presence of BAY 41-2272 at 100 μmol/L, treatment with GSNO at 3 μmol/L resulted in a rapid increase in cGMP up to 1000 pmol/109 platelets.
SJ-MX1605 Vericiguat 维利西呱

Vericiguat 是一种有效的口服可溶性鸟苷酸环化酶(sGC)的刺激物。

SJ-MX2128 Riociguat (BAY 632521) 利奥西呱 Riociguat (BAY 632521) 是一种可口服的可溶性鸟苷酸环化酶 (sGC) 刺激剂,常用于研究肺动脉高压症。
SJ-MX4659 NS-2028 NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM). It blocks sGC activity in murine cerebellum induced by S-nitroso-glutathione and NMDA (IC50 are 17 and 20 nM respectively). NS 2028 also inhibits VEGF-induced cGMP accumulation.
SJ-MX0346 Lificiguat (YC-1) 利非西呱

Lificiguat (YC-1)是一种不依赖于NO的可溶性鸟苷酸环化酶(soluble guanylyl cyclase,sGC)激活剂,在CO存在条件下,Kd 为 0.6-1.1 μM。Lificiguat (YC-1)是Hypoxia-inducible factor-1alpha (HIF-1α)抑制剂。

SJ-MD0017 Methylene Blue 亚甲兰 Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015)在色素内镜检查中被作用染料。它能抑制tau蛋白丝的形成,IC50为1.9μM,同时还抑制可溶性鸟苷环化酶。
SJ-BP0094 Plecanatide 普卡那肽 Plecanatide是尿鸟苷蛋白的类似物,是一种具有口服活性的鸟苷酸环化酶C受体(guanylate cyclase-C (GC-C) receptor)激动剂,在T84细胞实验中激活GC-C受体以刺激cGMP合成的EC50值为190 nM。Plecanatide在小鼠结肠炎模型中具有抗炎活性。