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CaSR

CaSR相关产品(8)
货号 产品名 中文名称 产品描述
SJ-MX2717 Strontium Ranelate 雷尼酸锶 Strontium Ranelate (S-12911; Distrontium renelate; Protelos or Protos) is an antiosteoporotic drug, it can also slow the course of osteoarthritis of the knee by both increasing bone formation and reducing bone resorption, leading to a rebalance of bone turnover in favor of bone formation. Strontium Ranelate is a strontium(II) salt of ranelic acid acting as an activator of the calcium-sensing receptor (CaSR) in non skeletal cells.
SJ-MX2111 Cinacalcet (AMG 073) hydrochloride 盐酸甲状旁腺激素 Cinacalcet hydrochloride (AMG 073 hydrochloride) 是一种可口服的 Ca receptor (CaR) 激动剂,用于心血管疾病研究。
SJ-MX4207 SB-423562 SB-423562 是一种短效的 (CaR) 拮抗剂。SB-423562 具有用于研究骨质疏松症的潜力。
SJ-MX2112 NPS-2143 (SB-262470A) NPS-2143 (SB-262470A),口服活性溶钙剂, 是选择性的钙敏感受体 (CaSR) 拮抗剂。NPS-2143 (SB-262470A) 通过激活表达人 Ca2+ 受体的 HEK 293 细胞中的 Ca2+ 受体而引起的胞浆 Ca2+ 浓度增加 (IC50=43 nM)。
SJ-BP0202 Etelcalcetide Etelcalcetide (formerly known as AMG-416, KAI-4169; ONO5163; velcalcetide, trade name Parsabiv) is a calcimimetic drug for the treatment of secondary hyperparathyroidism in chronic kidney disease (CKD) patients undergoing hemodialysis. It is administered intravenously at the end of each dialysis session. Etelcalcetide functions by binding to and activating the calcium-sensing receptor in the parathyroid gland.
SJ-MN1298 Ligustroflavone 女贞苷 Ligustroflavone 可从Ligustrum lucidum 中提取得到,是一种潜在的钙敏感受体(CaSR) 拮抗剂。Ligustroflavone对糖尿病性骨质疏松症小鼠有保护作用。
SJ-MX2112A NPS-2143 hydrochloride NPS-2143 hydrochloride (also known as SB-262470 and SB-262470A) is a novel, potent and selective antagonist of calcium-sensing receptor (CaSR) with IC50 of 43 nM. NPS-2143 stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents.
SJ-MX2344 Cinacalcet 西那卡塞 Cinacalcet (also known as AMG-073; trade names Sensipar, Mimpara) is a calcimimetic that mimics the action of calcium on tissues by allosteric activation of the calcium-sensing receptor expressed in various human organ tissues. It  is a novel class of compounds for the treatment of hyperparathyroidism. Cinacalcet is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR. In the presence of calcium ions, it can inhibit parathyroid hormone secretion by activating CaSR in parathyroid glands.