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Angiotensin-converting Enzyme (ACE)

Angiotensin-converting Enzyme (ACE)相关产品(24)
货号 产品名 中文名称 产品描述
SJ-MX3779 Omapatrilat Omapatrilat (also known as BMS-186716) is a novel antihypertensive agent that acts as a potent dual inhibitor of the metalloproteases ACE (angiotensin converting enzyme) and NEP (neutral endopeptidase) with Ki values of 0.64 and 0.45 nM, respectively. Omapatrilat has antihypertensive activity. NEP inhibition results in elevated natriuretic peptide levels, promoting natriuresis, diuresis, vasodilation, and reductions in preload and ventricular remodeling. The drug was promoted for possible uses in congestive heart failure.
SJ-MX2496 Alacepril Alacepril, also known as Cetapril and DU-1219, is an angiotensin-converting enzyme inhibitor and is commonly used as an antihypertensive.
SJ-MX1662 MLN-4760 MLN-4760 是一种有效、选择性的人 ACE2 抑制剂,IC50 值为 0.44 nM,对其选择性是对其他相关蛋白的 5000 多倍,包括人睾丸 ACE (IC50,>100 μM) 和牛 carboxypeptidase A (IC50,27 μM)。
SJ-BP0185 Alamandine Alamandine 是一种血管活性肽,是肾素-血管紧张素系统 (RAS) 的一个组成部分,还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可以调节血压,通过抗高血压作用来保护肾脏和心脏。
SJ-MX1927A Enalapril maleate 马来酸依那普利 Enalapril maleate is a potent angiotensin converting-Enzyme (ACE) inhibitor used to treat for hypertension and heart failure. As a prodrug, enalapril is converted by de-esterification into its active form enalaprilat. Enalaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation.
SJ-MX2556 Fosinopril sodium 福辛普利钠 Fosinopril sodium is the ester prodrug of fosinoprilat, an angiotensin converting enzyme (ACE) inhibitor. In vivo, fosinopril is rapidly hydrolyzed to fosinoprilat in the gastrointestinal mucosa and liver.
SJ-MX2832 Quinapril hydrochloride Quinapril hydrochloride (formerly CI-906, PD-109452-2; Acequin; Korec; Accupril; Accuprin; Accupril), the hydrochloride salt form of quinapril which is the prodrug of quinaprilat, is an angiotensin-converting enzyme/ACE inhibitor with anti-hypertensive effects. It is an approved antihypertensive drug that inhibits ACE with a Ki of 20 μM. Quinapril is a prodrug that has to to be converted in vivo to its active metabolite, quinaprilat.
SJ-MX2837 Benazepril hydrochloride 盐酸贝那普利 Benazepril hydrochloride is a prodrug of the angiotensin converting enzyme (ACE) inhibitor benazeprilat. It is metabolized to benazeprilat by hepatic esterases. Benazepril inhibits the in vitro enzymatic activity of partially purified ACE isolated from rabbit lung (IC50 = 2 nM). Reduces blood pressure and myocardial hypertrophy in spontaneous hypertensive rats.
SJ-MX2838 Benazepril 贝那普利 Benazepril (CGS-14824A; Cibacène; Cibacen; Briem; Labopal; Lotensin), a prodrug that has to be metabolized to the active form benazeprilat, is an angiotensin I converting enzyme (ACE) inhibitor that has approved for treatment of hypertension.
SJ-MX3326 Captopril (SQ 14225) 卡托普利 Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 0.022 μM). Also inhibits the bifunctional Zn2+-containing leukotriene A4 hydrolase/aminopeptidase (LTA4 hydrolase) reversibly and competitively (Ki = 6.0 μM for leukotriene B4> formation and Ki = 60 nM for L-lysine-p-nitroanilide). Displays vasodilatory and antihypertensive effects in vivo. Clinically useful antihypertensive agent.
SJ-MX3412 Imidapril hydrochloride 盐酸咪达普利 Imidapril hydrochloride is a prodrug for the active metabolite imidaprilat, an angiotensin-converting enzyme (ACE) inhibitor that suppresses the conversion of angiotensin I to angiotensin II (IC50 = 2.6 nM), thereby preventing vasoconstriction and decreasing aldosterone secretion by the adrenal cortex which leads to an increase in sodium excretion and subsequently increases water outflow.
SJ-MN0265 Phosphoramidon Disodium 磷酰二肽,膦酰二肽钠 Phosphoramidon Disodium 是金属蛋白酶 (metalloprotease) 抑制剂 。抑制内皮素转化酶 (ECE) ,中性肽内切酶 (NEP) 和血管紧张素转换酶 (ACE) 的IC50 值分别为 3.5 ,0.034 和 78 μM。
SJ-MX1927 Enalaprilat (MK-422) dihydrate 依那普利拉二水合物 Enalaprilat dihydrate (MK-422) 是血管紧张素转化酶 (ACE) 抑制剂,IC50 为 1.94 nM。
SJ-BP0117 Angiotensin (1-7) 血管紧张素 (1-7)

Angiotensin1-7(Ang-(1-7))是肾素-血管紧张素系统(RAS)中的一种内源性七肽,与血管紧张素转换酶2(ACE2)及Mas受体共同构成ACE2-Ang-(1-7)-Mas轴,起到拮抗ACE-AngⅡ-AngⅡ 1型受体轴的作用。由于其在心肌细胞中的抗炎和抗纤维化活性而具有心脏保护作用。Angiotensin1-7抑制纯化的犬血管紧张素转换酶活性,值为0.65 μM。Angiotensin1-7通过抑制血管紧张素转换酶和释放一氧化氮,可作为激肽诱导的血管舒张的局部协同调节剂。Angiotensin1-7阻断AngII诱导的平滑肌细胞增殖和肥大,并显示对内皮的抗血管生成和生长抑制作用。Angiotensin1-7显示出抗炎活性。

SJ-MN1281 Sinapinic acid 芥子酸 Sinapinic acid (Sinapic acid) 是从 Hydnophytum formicarum Jack. 根中分离到的酚类化合物,为 HDAC 的抑制剂,IC50 值 2.27 mM,对 ACE-I 的活性也有抑制作用。Sinapinic acid 具有有效的抗肿瘤活性,诱导肿瘤细胞凋亡。Sinapinic acid 具有抗氧化、抗糖尿病的作用。Sinapinic acid 可以降低卵巢切除大鼠的总胆固醇、甘油三酯和 HOMA-IR 指数,并使抗氧化能力和氧化损伤的一些血清参数正常化。
SJ-MX4492 Ramipril 雷米普利 Ramipril is a non-peptide, angiotensin converting enzyme (ACE) inhibitor (IC50 = 5 nM). A prodrug that is hydrolyzed in vivo to the active metabolite ramiprilat. Displays protective effects on endothelium against high-glucose induced dysfunction. Displays antihypertensive effects.
SJ-BP0189 Lisinopril 赖诺普利 Lisinopril (MK-521; MK521; Zestril; Linopril; Lisipril) is a potent angiotensin-converting enzyme (ACE) inhibitor approved for use in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes. Lisinopril significantly reduces left ventricular (LV) end-diastolic pressure (EDP), pulmonary capillary wedge pressure (PCWP) and end-diastolic stress, addition of atenolol to Lisinopril further reduces EDP and PCWP. Lisinopril is a structural homologue of enalaprilat, differing only in the second amino acid side chain.
SJ-MX2945 Temocapril hydrochloride 盐酸替莫普利 Temocapril hydrochloride is the hydrochloride of Temocapril, which is a long-acting angiotensin-converting enzyme (ACE) inhibitor, it is used for the treatment of hypertension. Temocapril is a prodrug-type ACE inhibitor not approved for use in the United States, but is approved in Japan and South Korea. Temocapril can also be used in hemodialysis patients without risk of serious accumulation.
SJ-MX4490 Cilazapril monohydrate Cilazapril monohydrate is a pyridazine angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat.
SJ-MX4491 Trandolapril Trandolapril (RU-44570), an antihypertensive drug, is an oral and nonsulfhydryl prodrug that has to be hydrolysed to the active diacid Trandolaprilat. It is a potent ACE inhibitor used to treat high blood pressure.