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Prostaglandin Receptor

Prostaglandin Receptor相关产品(45)
货号 产品名 中文名称 产品描述
SJ-MX1006 Tranilast 曲尼斯特

Tranilast (SB 252218, MK-341)是一种临床抗过敏药物,对哮喘和过敏性皮炎具有较好的效果和安全性。Tranilast可通过抑制NLRP3炎症小体改善其驱动的相关炎症性疾病。Tranilast抑制前列腺素 D2 产生 (PGD2,IC50=0.1 mM)。具有抗炎和免疫调节作用。

SJ-MX3375 Selexipag Selexipag (NS-304) is an orally available and long-acting prodrug of MRE 269, a potent and highly selective IP receptor agonist (Ki values 20 nM and 260 nM for inhibition of [3H]iloprost binding to human IP receptor by MRE 269 and Selexipag, respectively). Capable of ameliorating vascular endothelial dysfunction, pulmonary arterial wall hypertrophy, and right ventricular hypertrophy. Furthermore, Selexipag (NS 304) elevated right ventricular systolic pressure and improved survival in a rat model of pulmonary hypertension induced by monocrotaline (MCT).
SJ-MX3447 AH 6809 AH6809 is a DP/EP prostanoid receptor antagonist.
SJ-MX3556 Terutroban Terutroban is a selective TP (thromboxane-prostaglandin receptor) receptor antagonist, i.e. a specific antagonist of the thromboxane A(2) and prostaglandin endoperoxide receptors, shown to improve endothelial function after a single administration in patients with coronary artery disease. Terutroban, by chronically improving endothelium-dependent vasodilatation and inhibiting platelet aggregation, may prove useful for preventing cardiovascular events in high-risk patients.
SJ-MX3571 Evatanepag Evatanepag (formerly known as CP-533536; CP-533536 free acid) is a novel, potent and selective agonist of EP2 receptor prostaglandin E2 (PGE2). It induces local bone formation with EC50 of 0.3 nM. CP-533536 demonstrates the ability to heal fractures when administered locally as a single dose in rat models of fracture healing. CP-533536 demonstrates excellent in vitro potency against EP2 and selectivity against a broad panel of other targets.
SJ-MX3593 GW627368 GW627368 (GW627368X) 是前列腺素受体 EP4 高效选择竞争性抑制剂,还对血栓素受体 TP 有亲和力。对人 EP4 和 TP 的 pKi 值分别为 7.0 和 6.8。
SJ-MH0052 Latanoprost 拉坦前列素 Latanoprost (PHXA-41, XA-34) is a novel prostaglandin F2α analogue that lowers the pressure by increasing the outflow of aqueous fluid from the eyes through the uvealsclearal tract. Latanoprost is an isopropyl ester prodrug, meaning it is inactive until it is hydrolyzed by esterases in the cornea to the biologically active acid. Latanoprost, in pure form, is an oily liquid. For the convenience of use, it is supplied as 200mg / mL in ethanol.
SJ-MX2734 Travoprost 曲伏前列素 Travoprost (also known as Fluprostenol isopropyl ester; AL6221; Flu-Ipr; brand name Travatan) is medication used to treat high pressure inside the eye including glaucoma. Specifically it is used for open angle glaucoma when other agents are not sufficient. It is used as an eye drop. Effects generally occur within 2 hours.
SJ-MX1648 Grapiprant Grapiprant是一种选择性EP4受体拮抗剂,生理配体为前列腺素E2(PGE2)。
SJ-MX2144 Prostaglandin E1 (Alprostadil) 前列地尔

Prostaglandin E1 (Alprostadil) 是一种前列腺素受体配体,对小鼠 EP3、EP4、EP2、IP 和 EP1 的 Ki 值分别为 1.1 nM、2.1 nM、10 nM、33 nM 和 36 nM。Prostaglandin E1 诱导血管舒张并抑制血小板聚集。Prostaglandin E1 可作为血管扩张剂用于外周血管疾病的研究。注:该产品在溶液状态不稳定,建议您现用现配。

SJ-MN0250 Epibetulinic acid 表白桦脂酸 Epibetulinic acid is a natural product isolated from the root bark of Maytenus cuzcoina and the leaves of Maytenus chiapensis with anti-inflammatory activity. Epibetulinic acid inhibits NO and prostaglandin E2 (PGE2) production in mouse macrophages stimulated with bacterial endotoxin with IC50 of 0.7 μM and 0.6 μM, respectively.
SJ-MX2275 Seratrodast 塞曲司特 Seratrodast (AA 2414) is a thromboxane A2 (TP) receptor antagonist used in the treatment of asthma.
SJ-MX2520 Benorilate 贝诺酯 Benorilate, formerly known as Win-11450, is an ester of aspirin and paracetamol with analgesic, antipyretic, and anti-inflammatory activity used in the treatment of rheumatoid diseases. Benorilate has less severe side effects than aspirin.
SJ-MX2602 Ethamsylate 酚磺乙胺 Ethamsylate (Etamsylate) 是一种止血药物, 也抑制和前列腺素的生物合成和作用。
SJ-MH0058 Iloprost 伊洛前列素 Iloprost is a second generation synthetic analog of prostacyclin derived from carbacyclin, exhibiting approximately 10-fold greater potency than the first generation stable analogs of prostacyclin, represented by carbacyclin. Iloprost binds with high affinity to the prostanoid receptors, with Ki values being 11, 11 and 56 nM for the human recombinant IP, EP1 and EP3 receptors, respectively.
SJ-MX2145 PF-04418948 PF-04418948是一种有口服活性,有效和选择性的前列腺素EP2受体拮抗剂,IC50 为16 nM。
SJ-MX0007 AZD1981 AZD1981是CRTh2(DP2; GPR44)高效选择性拮抗剂。
SJ-MN1278 p-Hydroxycinnamic acid 对羟基肉桂酸 p-Hydroxycinnamic acid 是一种常见的食用酚,能够抑制血小板 (platelet) 的活性,其对血栓素 B2 和前列腺素 E2 的 IC50 值分别为 371 mM,126 mM。
SJ-MX3990 Treprostinil 曲前列尼尔 Treprostinil (LRX-15), a synthetic analog of prostacyclin (PGI2), is a novel and potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively. Treprostinil is a vasodilator that is used for the treatment of pulmonary arterial hypertension.
SJ-MX4211 MK-7246 MK-7246 is a novel, potent and selective CRTH2 antagonist with Ki of 2.5±0.5 nM. MK-7246 has high affinity for the human, monkey, dog, rat, and mouse CRTH2, it interacts with CRTH2 in a reversible manner, it exhibits high selectivity over all prostanoid receptors as well as 157 other receptors and enzymes, it acts as a full antagonist on recombinant and endogenously expressed CRTH2.