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Glucagon Receptor

Glucagon Receptor相关产品(14)
货号 产品名 中文名称 产品描述
SJ-BP0013 Liraglutide 利拉鲁肽

Liraglutide (Victoza, Liraglutida, Liraglutidum, NN2211) 是一种胰高血糖素样肽-1 (GLP-1) 受体激动剂,用于研究 2 型糖尿病。Liraglutide 的活性由其与GLP-1受体间特定的相互作用介导,导致环磷酸腺苷(cAMP)的增加。Liraglutide 能够以葡萄糖浓度依赖的模式刺激胰岛素的分泌,同时以葡萄糖浓度依赖的模式降低过高的胰高糖素的分泌。

SJ-MX3450 PF-06291874 PF-06291874 is a glucagon receptor antagonist potentially useful for patients with type 2 diabetes mellitus.
SJ-MX3772 Avexitide Avexitide (Exendin (9-39)) 是特异竞争性的 glucagon-like peptide-1 (GLP-1) 受体拮抗剂。
SJ-MX3798 BETP BETP at the glucagon-like peptide 1 receptor (GLP-1; EC50 value 0.66 μM) with good selectivity over GLP-2, GIP, PTH, and glucagon receptors. BETP has a signifficant effect on cAMP accumulation, iCa2+ mobilization, and β-arrestin1 and β-arrestin2 recruitment in Flp-In-CHO cells stably expressing the human GLP-1R (pEC50 values 5.2, 5, 5.0, and 5.0, respectively). BETP induced glucose-dependent insulin secretion in vitro and in vivo, and increased calcium influx in CHO cells expressing GLP-1R.
SJ-MX4068 V-0219 V-0219是一种胰高血糖素样肽-1受体(glucagon-like peptide-1 receptor, GLP-1R)的口服活性正变构调节剂(positive allosteric modulator, PAM),可用于肥胖相关糖尿病的研究。
SJ-MX4045 GLP-1R Antagonist 1 GLP-1R Antagonist 1 (compound 5d) 是口服有效的、能透过中枢神经系统的,胰高血糖素样肽 1 受体 (GLP-1R) 的非竞争性抑制,其IC50 值为 650 nM。
SJ-MX3849 GRA Ex-25 GRA Ex-25 is a novel and potent inhibitor of glucagon receptor with IC50 of 56 and 55 nM for rat and human glucagon receptors, respectively. GRA Ex-25 binds a human glucagon receptor (h-GlucRbind) with Ki of 63 nM and a moderate glucagon induced adenylate cyclase inhibition (h-GlucRcyclase) with Ki of 254 nM under our assay conditions.
SJ-MX4158 Lixisenatide Lixisenatide (ZP10A; ZP-10A; AVE-0010) is a short-acting agonist of the glucagon-like peptide-1 receptor (GLP-1R) with anti-diabetic effects. It activates GLP-1R with IC50 value of 1.4 nM in in vitro receptor binding studies.
SJ-MX4641 NNC-0640 NNC0640 is a novel and potent modulator of glucagon-like peptide-1 receptor (GLP-1R).
SJ-MX2123 Adomeglivant (LY2409021) 阿度格列凡 Adomeglivant (LY2409021) 是一种有效的选择性胰高血糖素受体 (GluR) 变构拮抗剂。Adomeglivant 广泛应用于 2 型糖尿病的研究。
SJ-BP0072 Porcine glucagon 胰高血糖素 Porcine glucagon[Glucagon (1-29), bovine, human, porcine ]是由胰腺α细胞产生的一种多肽激素。Glucagon 促进糖异生。Glucagon (1-29), bovine, human, porcine 可激活 HNF4α并促进 HNF4α磷酸化。
SJ-BP0071 GLP-1(7-37) 人胰高血糖素样肽-1 GLP-1(7-37) 是一种肠道胰岛素激素,可以增强葡萄糖诱导的胰岛素分泌。
SJ-BP0068 Exenatide Acetate 艾塞那肽 Exendin-4 (Exenatide) 是由 39 个氨基酸组成的多肽。它是长效的 glucagon-like peptide-1 受体激动剂,IC50 值为 3.22 nM。
SJ-BP0038 Semaglutide 索玛鲁肽 Semaglutide 是人胰高血糖素样肽-1 的一个长效类似物, 是人胰高血糖素样肽-1 (GLP-1) 受体的激动剂。Semaglutide 有潜力用于 2 型糖尿病的研究。