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SPHK

SPHK相关产品(9)
货号 产品名 中文名称 产品描述
SJ-MX0667 SKI II

SKI II (SphK-I2)是一种高度选择性的,非ATP竞争性的口服有效的鞘氨醇激酶(sphingosine kinase,SphK)抑制剂,IC50为0.5 μM。SKI II 对其他激酶,包括PI3K, PKCα和ERK2没有抑制作用。SKI II抑制小鼠肿瘤细胞增殖,诱导凋亡,抑制肿瘤生长。

SJ-MX3538 K145 hydrochloride K145 hydrochloride is a selective, substrate competitive Sphingosine Kinase-2 inhibitor (SphK2; IC50 value 4.30 µM) and anticancer agent. K145 suppressed the S1P level, and significantly inhibited the growth of U937 tumors in nude mice by both intraperitoneal and oral administration.K145 significantly inhibited the phosphorylation of FTY720, ERK and Akt upon treatment of U937 cells, but does not interfere with CERK and/or ceramide synthase.
SJ-MV0069 Peretinoin Peretinoin, formerly known as NIK-333 , orally bioavailable, acyclic retinoid with potential antineoplastic and chemopreventive activities. Peretinoin binds to and activates nuclear retinoic acid receptors (RAR), which in turn recruit coactivator proteins and promote, with other transcriptional complexes, the transcription of target genes. As a result, this agent may modulate the expression of genes involved in the regulation of cell proliferation, cell differentiation, and apoptosis of both normal and tumor cells.
SJ-MX0835 Opaganib (ABC294640) 奥帕尼布 Opaganib (ABC294640) 是一种选择性的竞争性的鞘氨醇激酶 2 (SK2) 抑制剂,Ki 为 9.8 μM。
SJ-MX4053 K6PC-5 K6PC-5 is a sphingosine kinase 1 (SphK1 or SK1) activator that increases sphingosine-1-phosphate (S1P) production, induces Akt phosphorylation in cultured osteoblasts, and protects them from Dex-induced apoptosis and necrosis.
SJ-MX1079 MHP MHP是一种鞘氨醇激酶 (SPHK1) 激活剂,可显著增加 CAMP mRNA 和蛋白水平。MHP (Methyl caprooyl tyrosinate) 可增强抗微生物防御能力和先天免疫力。
SJ-MX0637A PF-543 hydrochloride

PF-543盐酸盐(Sphingosine Kinase 1 Inhibitor II)是一种新型的、有效的、细胞渗透性的鞘氨醇竞争抑制剂SphK1,IC50 和 Ki 分别为 2.0 nM 和 3.6 nM,选择性是 SphK2 亚型的100倍的以上。

SJ-MX0637 PF-543 PF-543 (Sphingosine Kinase 1 Inhibitor II) 是一种有效,选择性,可逆和鞘氨醇竞争性 SPHK1 抑制剂,IC50 为 2 nM,Ki 为 3.6 nM。PF-543 对 SPHK1 的选择性是 SPHK2 的 100 倍以上。PF-543 还是有效的全血中 1-磷酸鞘氨醇 (S1P) 形成的有效抑制剂,IC50 为 26.7 nM。PF-543 诱导细胞凋亡(apoptosis),坏死和自噬(autophagy)。
SJ-MN0038 Phorbol 12-myristate 13-acetate (PMA) 佛波酯

Phorbol 12-myristate 13-acetate(PMA)是一种有效的 PKC 激活剂,在纳摩尔浓度范围内具有活性作用。Phorbol 12-myristate 13-acetate(PMA)可诱导 sphingosine-1-phosphate(S1P)。