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Thrombin

Thrombin相关产品(13)
货号 产品名 中文名称 产品描述
SJ-MN0056 Heparin sodium 肝素钠 Heparin sodium 是一种抗凝剂,可与抗凝血酶III (ATIII) 可逆地结合,大大加快了ATIII使凝血酶因子IIa 和 Xa 失活的速度。Heparin sodium 显著抑制外泌体-细胞相互作用。
SJ-MX0842 Dabigatran (BIBR 953) 达比加群

Dabigatran (BIBR 953)是一种口服可逆的,竞争性的、非肽类直接凝血酶 (thrombin) 抑制剂,无细胞试验中IC50为9.3 nM。Dabigatran (BIBR 953) 也抑制凝血酶诱导的血小板聚集 (IC50=10 nM)。

SJ-MX2819 Edoxaban (DU-176) 依度沙班 Edoxaban (also known as DU-176b; DU176; Lixiana; Savaysa) is a potent, direct-acting, selective, orally bioavailable factor Xa inhibitor used as an anticoagulant drug. It inhibits factor Xa with a Ki of 0.561 nM, >10 000-fold selectivity over thrombin and FIXa. Edoxaban acts as a direct factor Xa inhibitor.
SJ-MX2944 Edoxaban tosylate monohydrate Edoxaban tosylate monohydrate (DU-176b; DU-176; trade name Lixiana), the tosylate salt of edoxaban which is a marketed anticoagulant drug, is a potent, selective, orally bioavailable and direct factor Xa inhibitor with potential anti-coagulant activity. It inhibits Factor Xa with a Ki of 0.561 nM, and exhibits >10 000-fold selectivity over thrombin and FIXa.
SJ-MX3417 AEBSF hydrochloride

AEBSF hydrochloride 是一种特异性的、不可逆的丝氨酸蛋白酶抑制剂。抑制蛋白酶,如凝乳蛋白酶,激肽酶,纤溶酶,凝血酶和胰蛋白酶。一种稳定,无毒,更好溶的PMSF替代品。

SJ-MX1086 NQ301 NQ301是一种抗血栓剂; 可抑制胶原蛋白激发的兔血小板聚集,IC50值为10 mg/mL。
SJ-MN0302 Argatroban 阿加曲班 Argatroban (MD-805) 是凝血酶选择性抑制剂。
SJ-MN0302A Argatroban monohydrate 阿加曲班一水合物 Agatroban is a potent and competitive thrombin inhibitor (Ki = 19 nM) that displays anticoagulant activity. Active in vivo.
SJ-BP0042 Enoxaparin sodium 依诺肝素钠

Enoxaparin sodium是一种低分子量的合成肝素。 作为一种抗凝剂/抗血栓剂,Enoxaparin sodium的作用机制与heparin相似,尽管它表现出更高的抗因子 Xa 与抗因子 IIa 活性的比率。Enoxaparin sodium还具有抗炎特性,可抑制单核细胞与肿瘤坏死因子 α 或脂多糖激活的内皮细胞的粘附。 与普通heparin相比,Enoxaparin sodium的使用与骨质疏松症和肝素诱导的血小板减少症的发生率降低有关。

SJ-MX2789 Dabigatran etexilate 达比加群酯 Dabigatran etexilate (BIBR 1048) is a reversible and selective, direct thrombin inhibitor (DTI) with Ki value of 4.5 nM. Dabigatran selectively and reversibly inhibits human thrombin (Ki = 4.5 nM) as well as thrombin-induced platelet aggregation (IC50 = 10 nM), while showing no inhibitory effect on other platelet-stimulating agents. Dabigatran displays concentration-dependent anticoagulant effects in various species in vitro.
SJ-MX2789A Dabigatran etexilate mesylate 甲磺酸达比加群酯 Dabigatran Etexilate mesylate (BIBR-1048; BIBR 1048MS) is the prodrug of dabigatran which is a potent and nonpeptidic small molecule that specifically and reversibly inhibits both free and clot-bound thrombin by binding to the active site of the thrombin molecule. Dabigatran (also known as IBR 953) is a potent nonpeptide thrombin inhibitor with an IC50 of 9.3 nM in a cell-free assay. Dabigatran is designed to be converted into an orally active prodrug BIBR 1048 due to its highly polar, zwitterionic nature and poor oral absorption. Dabigatran inhibits thrombin in a competitive fashion.
SJ-BP0057A Bivalirudin TFA 三氟醋酸比伐卢定 Bivalirudin TFA 是20个氨基多肽,可逆地抑制凝血酶。
SJ-BP0057 Bivalirudin Bivalirudin,一种肽类抗凝剂,是直接凝血酶 (thrombin) 抑制剂,可在侵入性心脏病,特别是在经皮冠状动脉介入中用于抗凝。