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Dopamine Receptor

Dopamine Receptor相关产品(85)
货号 产品名 中文名称 产品描述
SJ-MM0031 MPTP hydrochloride

MPTP hydrochloride可透过血脑屏障的多巴胺 (dopamine) 神经毒素,通过杀死大脑黑质中的某些神经元而导致帕金森病的永久性症状,可用于帕金森病相关研究的工具化合物。MPTP hydrochloride 是 MPP+ 的前体,可以诱导凋亡 (apoptosis) 作用。

SJ-MX2987 cis-(Z)-Flupentixol dihydrochloride cis-(Z)-Flupentixol dihydrochloride 是有效、选择性的多巴胺DA D1/D2 受体的拮抗剂,其对D2 受体和 5-HT2A 的 Ki 值分别为 0.38 nM 和 7 nM。
SJ-MX3784 Veralipride 维拉必利 Veralipride is a benzamide neuroleptic medicine indicated in the treatment of vasomotor symptoms associated with the menopause.
SJ-MX2562 Clebopride malate 苹果酸氯波必利 Clebopride malate is a dopamine antagonist drug with antiemetic and prokinetic properties used to treat functional gastrointestinal disorders.
SJ-MX4373 Fluphenazine dihydrochloride 盐酸氟奋乃静

Fluphenazine dihydrochloride(Prolixin)是多巴胺受体 D1DR 和 D2DR 抑制剂。它能够抑制组胺H1受体。

SJ-MX1489 Itopride hydrochloride 盐酸伊托必利 Itopride hydrochloride (HSR803) 是一种促胃动力的 Benzamide (HY-Z0283) 衍生物。Itopride hydrochloride 是一种乙酰胆碱酯酶 (AChE) 和多巴胺受体 D2 (D2DR) 抑制剂。
SJ-MX1493 Brexpiprazole 依匹哌唑 Brexiprazole(OPC-34712),一种非典型抗精神病药,是人5-HT1A和多巴胺受体的部分激动剂,Ki分别为0.12nM和0.3 nM。Brexpiprazole也是5-HT2A受体的拮抗剂,Ki为0.47 nM。
SJ-MX1499 Perospirone hydrochloride 盐酸哌罗匹隆 Perospirone hydrochloride (SM-9018) 是具有口服活性的 5-HT2A 受体 (Ki 为 0.6 nM) 和多巴胺 D2 受体 (Ki 为 1.4 nM) 的拮抗剂,也是 5-HT1A 受体 (Ki 为 2.9 nM) 的部分激动剂。Perospirone hydrochloride 是一种非典型的抗精神病剂,可用于精神分裂症的研究。
SJ-MX1518 Promazine hydrochloride 盐酸丙嗪 Promazine (Romtiazin) hydrochloride是一种抗精神病药和多巴胺受体 (D2) 拮抗剂。Promazine hydrochloride 抑制多巴胺能神经传递。
SJ-MX1619 ONC206 ONC206是ONC201的一个类似物。ONC206是多巴胺D2-样受体(DRD2/3/4)的选择性拮抗剂,其拮抗作用在纳摩尔级别。ONC206具有广谱的抗肿瘤作用。
SJ-MX1369 Tribenzagan Hydrochloride 盐酸曲美苄胺 Trimethobenzamide hydrochloride 是多巴胺 D2 受体阻断剂,可用作预防恶心和呕吐的止吐剂。
SJ-MX1400A Quetiapine hemifumarate 富马酸喹硫平 Quetiapine hemifumarate 是一种 5-HT 受体激动剂,对人 5-HT1A 的 pEC50 值为 4.77。Quetiapine hemifumarate 是多巴胺受体 (dopamine receptor) 拮抗剂,对人 D2 的 pIC50 值为 6.33。Quetiapine hemifumarate 对人 D2,HT1A,5-HT2A,5-HT2C 受体具有中高等亲和力,pKi 值为 7.25,5.74,7.54,5.55。具有抗抑郁和抗焦虑作用。
SJ-MX2371 Triflupromazine hydrochloride 盐酸三氟丙嗪 Triflupromazine hydrochloride is a member of a class of drugs called phenthiazines, which are dopamine D1/D2 receptor antagonists.Triflupromazine hydrochloride binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. Used as an antipsychotic drug.
SJ-MX2501 Alizapride hydrochloride 盐酸阿立必利 Alizapride hydrochloride (Limican; Plitican; Vergentan; Superan; Alizaprida; Litican; MS-5080), the hydrochloride salt of alizapride which is a medication used for the theropy of nausea and vomiting, is a potent dopamine receptor antagonist with prokinetic and antiemetic effects.
SJ-MX2541 Bromocriptine mesylate 甲磺酸溴隐亭 Bromocriptine mesylate 是一种有效的多巴胺 D2/D3 受体激动剂,结合多巴胺 D2 受体,pKi 为 8.05±0.2。
SJ-MX2608 Fenoldopam mesylate 非诺多泮甲磺酸盐 Fenoldopam mesylate (SKF-82526) is a synthetic benzazepine analog acting as a selective D1 receptor partial agonist. Since fenoldopam is the only intravenous agent that improves renal perfusion, in theory it could be beneficial in hypertensive patients with concomitant renal insufficiency.
SJ-MX2639 Levosulpiride 左舒必利 Levosulpiride (RV 12309; RV-12309; S-(-)-Sulpiride) is the S-enantiomer of sulpiride, which is a potent and selective antagonist for D2 dopamine receptors used as an antipsychotic and prokinetic agent. Levosulpiride is a substituted benzamide antipsychotic, reported to be a selective antagonist of dopamine D2 receptor activity on both central and peripheral levels. It is an atypical neuroleptic and a prokinetic agent. Levosulpiride is also claimed to have mood elevating properties.
SJ-MX3295 Tetrahydropalmatine 延胡索乙素 Tetrahydropalmatine 可用于缓解疼痛的研究。Tetrahydropalmatine 通过抑制大鼠杏仁核的多巴胺释放来抑制癫痫发作。
SJ-MN1199 L-Stepholidine 左旋千金藤啶碱 L-Stepholidine (Stepholidine),一种从中草药 Stephania intermedia 提取的生物碱,是已知的第一种同时具有多巴胺受体 D1 (dopamine D1 receptor) 激动剂和多巴胺受体 D2 (dopamine D2 receptor) 拮抗剂。L-Stepholidine 具有神经保护作用,并抑制海洛因诱导的恢复。L-Stepholidine 是研究阿片成瘾的一种潜在试剂。
SJ-MX2847 Chlorprothixene 氯普噻吨 Chlorprothixene (Cloxan, Taractan, Truxal) is a typical antipsychotic drug of the thioxanthene class and was the first of the series to be synthesized.