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Carbonic Anhydrase

Carbonic Anhydrase相关产品(12)
货号 产品名 中文名称 产品描述
SJ-MX0795 Acetazolamide 乙酰唑胺

Acetazolamide (Diamox) 是一种碳酸酐酶 (carbonic anhydrase,CA) IX 抑制剂,抑制 hCA IX,IC50 为 30 nM。Acetazolamide的利尿作用是有限的,目前主要用于治疗青光眼。

SJ-MX2581 Dichlorphenamide 二氯苯二磺胺 Dichlorphenamide is a potent, orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively). It lowers intraocular pressure in rabbits when 50 µl of a 10% solution is applied topically to the eye. Used in the treatment of glaucoma and primary periodic paralysis.
SJ-MH0037 Fluorometholone acetate 氟米龙醋酸酯 Fluorometholone Acetate (formerly NSC47438; NSC-47438; U 17,323; AI 3-52814; Flarex) is a synthetic corticosteroid that has been approved as a medication commonly used as eye drops in the treatment of steroid responsive inflammatory conditions of the eye.
SJ-MX2485 Tioxolone 噻克索酮 Tioxolone (Thioxolone) is a potent inhibitor of metalloenzyme carbonic anhydrase I with a variety of activities such as cytostatic, antipsoriatic, anti-acne, antibacterial and anti-mycotic properties. It inhibits carbonic anhydrase I with a Ki of 91 NM. Tioxolone is also added to some cosmetics (e.g. hair shampoos and skin cleansers), due to claims for its oil-regulating and antibacterial properties.
SJ-MX2532 Brinzolamide 布林佐胺 Brinzolamide (AL-4862; AL4862; Azopt, Alcon Laboratories, Befardin, AL4862) is a highly potent and selective CAI (carbonic anhydrase II inhibitor) with anti-hypertensive activity. It inhibits carbonic anhydrase II with an IC50 of 3.19 nM. Brinzolamide is used to treat glaucoma (open angle-type) or other eye diseases (e.g. ocular hypertension).
SJ-MX2650 Methazolamide 醋甲唑胺 Methazolamide is a potent carbonic anhydrase (CA) inhibitor (IC50 = 130 nM) with anti-glaucoma, anti-diabetic, and potential anti-neoplastic activity. It reduces intraocular pressure and cerebrospinal fluid flow in a rat model of glaucoma.
SJ-MX3337 2-Aminobenzenesulfonamide 2-Aminobenzenesulfonamide 是碳酸酐酶 IX (carbonic anhydrase IX) 的抑制剂。
SJ-MX1211 U-104 (SLC-0111) U-104 (SLC-0111) 是一种有效的 CA IX 和 CA XII 碳酸酐酶 (CA) 抑制剂,Ki 值分别为 45.1 nM 和 4.5 nM。U-104 在小鼠模型中显示出明显的肿瘤生长延迟。
SJ-MX1296 Zonisamide 唑尼沙胺 Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的抑制剂,对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性。Zonisamide 可用于癫痫、癫痫发作和帕金森病的研究。
SJ-MX2232 Dorzolamide hydrochloride 盐酸多佐胺 Dorzolamide (L671152) hydrochloride 是有效的碳酸酐酶 carbonic anhydrase II 的抑制剂,其对红细胞CA-II 和CA-I 的 IC50 值分别为 0.18 nM 和 600 nM。
SJ-MX3687 Indisulam Indisulam (E 7070) 是一种碳酸酐酶抑制剂,具有抗癌活性。Indisulam (E 7070) 是细胞周期 G1 期的靶向化合物。Indisulam (E 7070) 通过抑制 CDK2 和周期蛋白 E 的激活,引起 G1/S 转化被阻滞。Indisulam (E 7070) 通过募集 DCAF15 诱导 RBM39 降解来靶向剪接。
SJ-MX1294 Topiramate 托吡酯 Topiramate (McN 4853) 是一种广谱抗癫痫药。Topiramate 也是一种 GluR5 受体拮抗剂,可通过增强 GABAergic 活性,抑制 kainate/AMPA 受体,抑制钠和钙通道的电压敏感,增加钾电导并抑制 carbonic anhydrase 来产生抗癫痫作用。