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Adenosine Receptor

Adenosine Receptor相关产品(37)
货号 产品名 中文名称 产品描述
SJ-MX0380 Ciforadenant (CPI-444)

Ciforadenant (CPI-444)是一种强效的、选择性的、可口服的A2AR拮抗剂抑制剂,Ki值为3.54 nM。Ciforadenant (CPI-444)显著增强癌症检查点治疗和ACTs模型的免疫应答。此外,Ciforadenant (CPI-444)在临床前模型中诱导抗肿瘤反应并增强抗PD-(L)1和抗CTLA-4的疗效。

SJ-MX2854 Tozadenant Tozadenant 是 adenosine A2A 受体拮抗剂,作用于人类和恒河猴的 adenosine A2A 受体,Ki 值分别为 11.5 nM 和 6 nM。
SJ-MX2981 Regadenoson 瑞加德松 Regadenoson (CVT-3146) 是一种有效的选择性 A2A 腺苷受体激动剂,对大鼠和猪腺苷 A2A 受体的 Ki 分别为 290 和 1120 nM。Regadenoson 对 A2A 受体的选择性高于人 A1 和 A2B 受体,其选择性是 A1 受体的 13 倍。Regadenoson 是一种血管扩张剂,它改变了血管扩张剂心肌灌注显像的前景。Regadenoson 增加了啮齿动物血脑屏障 (BBB) 的通透性。
SJ-MX2549 Capadenoson 卡帕诺生 Capadenoson (formerly also known as BAY 68-4986) is a novel, orally bioactive, potent and selective adenosine A1 receptor agonist. The adenosine A₁ receptor is one member of the adenosine receptor group of G protein-coupled receptors with adenosine as endogenous ligand. Adenosine A1 receptor (A1AR) stimulation is a powerful protective mechanism in cerebral and cardiac ischemia-reperfusion injury.
SJ-MX2554 CGS 21680 CGS 21680 是一种选择性的 adenosine A2A receptor 特异性激动剂,Ki 值为 27 nM。
SJ-MX1631 Preladenant(SCH-420814) Preladenant 是一种有效,竞争性的人腺苷 A2A 受体拮抗剂,Ki 为 1.1 nM,比其他腺苷受体选择性高100倍以上。
SJ-MX2099 MRS 1754 MRS 1754 是一种选择性 A2B 腺苷受体拮抗剂,对人和大鼠的 A1 和 A3 受体具有非常低的亲和力。
SJ-MX2506 Aminophylline 氨茶碱 Aminophylline (also known as Phyllocontin; Euphyllin; Truphylline), a bronchodilator composed of theophyllineand ethylenediamine in 2:1 ratio, is a novel, potent, competitive nonselective phosphodiesterase/PDE inhibitor with an IC50 of 0.12 mM. It is also a nonselective adenosine receptor antagonist. Aminophylline is used to treat wheezing, shortness of breath, and difficulty breathing caused by asthma, chronic bronchitis, emphysema.
SJ-MX2591 Doxofylline 多索茶碱 Doxofylline (also known as Neothylline; Ansimar; ABC-1213; ALT-07; Lufyllin; DO-309; Diprophylline; Corphyllin; ABC-12-3), a xanthine derivative, is a novel and potent PDE (phosphodiesterase) inhibitor with the potential for treating asthma. Doxofylline's mechanism of action is related to the inhibition of phosphodiesterase activities, but it appears to have decreased affinities towards adenosine A1 and A2 receptors, which may account for its better safety profile.
SJ-MX2728A Ticlopidine hydrochloride 盐酸噻氯匹定 Ticlopidine hydrochloride is orally bioavailable drug inhibiting ADP induced platelet aggregation. It is selective P2Y12 receptor antagonist and might be better alternative in the prevention of atherothrombotic stroke.
SJ-MX2093 Namodenoson Namodenoson (CF-102) 是一个选择性的 A3 腺苷受体 (A3AR) 激动剂 (Ki=0.33 nM),选择性分别是 A1,A2 的 2500 和 1400 倍。
SJ-MN0238 Theophylline-7-acetic acid 茶碱乙酸 Acefylline(Theophyllineaceticacid),一种黄嘌呤衍生物,是腺苷受体拮抗剂。Acefylline是蛋白质精氨酸脱亚氨酶激活剂。Acefylline也是一种支气管扩张剂,可以抑制大鼠肺cAMP磷酸二酯酶同工酶。
SJ-MN0280 Dyphylline 二羟丙茶碱 Diphylline(Diprophylline)是有效的腺苷受体拮抗剂,也是环状核苷酸磷酸二酯酶()抑制剂。Diphylline是一种黄嘌呤衍生物,具有支气管扩张和血管扩张作用,有潜在用于慢性支气管炎和肺气肿的潜力。
SJ-MN1385 Theobromine 可可碱 Theobromine 是在可可豆中发现的甲基黄嘌呤,可以抑制腺苷受体 A1 (AR1) 信号传导。
SJ-MN1533 Proxyphylline 羟丙茶碱 Proxyphylline 是一种甲基黄嘌呤衍生物,作为心脏活化剂,血管扩张剂和支气管扩张剂使用。
SJ-MX3923 MRS-1706 MRS-1706 is a selective adenosine A2B receptor inverse agonist with Kis of 1.39, 157, 112, and 230 nM for human A2B, A1, A2A, and A3 receptors, respectively.
SJ-MX4271 Adenosine amine congener Adenosine amine congener is potent A1 adenosine receptor agonist.
SJ-MX4364 PD 117519 PD 117519 (CI947) is a novel and potent adenosine agonist.
SJ-MX4368 N6-Cyclohexyladenosine N6-Cyclohexyladenosine是一种选择性的腺苷A1 受体激动剂 (EC50 = 8.2 nM)。
SJ-MX4546 A2A receptor antagonist 1 A2A-IN-1 is a potent and selective antagonist of A2A receptor.