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Progesterone Receptor

Progesterone Receptor相关产品(18)
货号 产品名 中文名称 产品描述
SJ-MX0939 Ulipristal

Ulipristal (CDB-3236; Deacetyl CDB-2914) 是一种选择性的孕酮受体调节剂(SPRM)。Ulipristal 与孕激素受体结合,从而抑制 PR 介导的基因表达,并干扰生殖系统中孕激素的活性。

SJ-MH0026 Mifepristone 米非司酮;美服培酮

Mifepristone (RU486)是黄体酮受体 (PR) 和糖皮质激素受体 (GR) 拮抗剂,体外实验中的 IC50 值分别为0.2 nM 和2.6 nM。Mifepristone 可促进细胞自噬和细胞凋亡,降低 Bcl-2 表达水平而增加Beclin1水平,并伴随Bcl-2和Beclin1之间的相互作用减弱。

SJ-MX2968 Ulipristal acetate 醋酸乌利司他 Ulipristal acetate (also known as CDB-2914) is a potent and selective SPRM (selective progesterone receptor modulator) for emergency contraception after an unprotected intercourse or contraceptive failure. Ulipristal acetate has partial agonistic as well as antagonistic effects on the progesterone receptor. It also binds to the glucocorticoid receptor, but has no relevant affinity to the estrogen, androgen and mineralocorticoid receptors. Ulipristal acetate dose dependently suppressed progesterone-induced acrosome reaction and hyperactivation in human spermatozoa.
SJ-MH0017 Dydrogesterone 地屈孕酮 Dydrogesterone 是口服活性的孕激素,可作用于孕酮缺乏相关疾病。
SJ-MH0039 Altrenogest Altrenogest, also known as allyltrenbolone or allyltrienolone, is a steroidal progestin of the 19-nortestosterone and allyltestosterone groups related to allylestrenol, norgestrienone, and trenbolone that is widely used in veterinary medicine to suppress or synchronize estrus in horses and pigs.
SJ-MH0042 Chlormadinone acetate Chlormadinone acetate is a synthetic steroid hormone and antagonist at androgen and estrogen receptors used to treat BPH and polycystic ovary syndrome. It also promotes osteoblast differentiation and Ca deposition in bone marrow stem cells.
SJ-MH0053 Megestrol acetate 醋酸甲地孕酮 Megestrol acetate (formerly BDH1298, SC10363; BDH-1298; SC-10363; Megace; Ovaban; Pallace; Maygace; Megestil; Niagestin) is a synthetic progestogen derivative that has been approved for use in the treatment of breast cancer and loss of appetite. Megestrol Acetate shows potent anti-proliferative activity in vitro against various cancer cell lines such as  HepG2 cells with an IC50 value of 260 μM.
SJ-MH0054 Norethindrone 炔诺酮 Norethindrone (Norethisterone) 一种孕激素,用于研究子宫内膜异位症、由激素水平异常引起的子宫出血和继发性闭经。
SJ-MH0057 Nestoron 醋酸烯诺孕酮 Nestoron, a synthetic progestin, is a high-affinity agonist of the progesterone receptor (EC50: 10.3 nM).
SJ-MH0062 Drospirenone Drospirenone is a synthetic progestin that is an analog to spironolactone.
SJ-MH0071 Desogestrel 去氧孕烯 Desogestrel (Org-2969)是第三代孕激素类似物,许多口服避孕制剂中含有。
SJ-MH0079 Ethynodiol diacetate 双醋炔诺醇 Ethynodiol diacetate is one of the first synthetic progestogens used in contraceptive pills.
SJ-MH0013 Levonorgestrel 左炔诺孕酮 Levonorgestrel是合成孕激素,可作用于孕酮受体。
SJ-MX3911 Cridanimod Cridanimod (XBIO-101) is a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Cridanimod is able to induce the expression of PR in endometrial cancer.
SJ-MH0028 Medroxyprogesterone acetate 醋酸甲羟孕酮

Medroxyprogesterone acetate (MPA, NSC-26386, Medroxyprogesterone 17-acetate, Farlutin)是一种孕激素,是一种人体孕激素的人工合成的变体,是有效的孕激素受体激动剂。

SJ-MH0030 Progesterone 黄体酮

Progesterone 是一种内源性的甾类激素,参与调节月经周期、怀孕、人类和其他物种的胚胎发育过程。是有效的nuclear progesterone receptor (nPR)激动剂,Kd值为1 nM;membrane progesterone receptors(mPRs)的激动剂、σ1 receptor的拮抗剂。

SJ-MX1286 Dienogest (STS 557) 地诺孕素 Dienogest(STS-557)是孕酮受体激动剂,有口服的子宫内膜活性,可作用于子宫内膜异位。
SJ-MH0027 Etonogestrel 依托孕烯 Etonogestrel是孕激素去氧孕烯的生物活性代谢物,Etonogestrel 与靶器官中的孕酮受体 (progesterone receptor) 和雌激素受体 (estrogen receptors) 高亲和力地结合。Etonogestrel 诱导 FKBP51 mRNA 和蛋白表达。