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MAGL

MAGL相关产品(7)
货号 产品名 中文名称 产品描述
SJ-MX3498 JZL195 JZL195 is a potent dual inhibitor of Monoacylglycerol lipase (MAGL) (IC50 = 2 nM) and fatty acid amide hydrolase (FAAH) (IC50 = 4 nM), enzymes that degrade the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA), the endogenous ligands for the cannabinoid G-protein coupled receptors CB1 and CB2. It poorly inhibits neuropathy target esterase and ABHD6 and does not inhibit other brain serine hydrolases. JZL 195 displays time-dependent inhibition of FAAH and MAGL in vivo, consistent with a covalent mechanism of activation.
SJ-MX4002 KML29 KML29是一种有效的选择性MAGL抑制剂, 抑制人, 小鼠, 和大鼠脑蛋白酶时, IC50 分别为5.9, 15, 和 43 nM。
SJ-MN0292 Tanshinone IIA 丹参酮IIA

Tanshinone IIA (Tan IIA) 是红根丹参根系中的主要组合物之一。Tanshinone IIA 可以通过靶向 VEGF/VEGFR2 的蛋白激酶结构域来抑制血管生成。Tanshinone IIA是天然的monoacylglycerol lipase(MAGL) 抑制剂。

SJ-MX2434 JZL 184

JZL 184 是一种有效的,选择性的且不可逆的 MAGL 抑制剂,可阻断脑膜中的 2-花生四烯酸甘油酯 (2-AG) 的水解 ,IC50 为 8 nM。JZL 184 对 MAGL 的选择性比 FAAH 高 300 倍以上。

SJ-MX1409 ABX-1431

ABX-1431是一种有效的、选择性、能穿透中枢神经系统的单酰基甘油脂酶(MGLL)抑制剂,对人源MGLL和鼠源MGLL的IC50值分别为14 nM和27 nM。

SJ-MX4230 MJN110 MJN110 is a potent, selective, and in-vivo-active MAGL inhibitor (IC50 values 9.5 nM and 260 nM for inhibition of mouse MAGL and ABHD6, respectively) displaying strong antihyperalgesic activity (mechanical allodynia) in a rat model of diabetic neuropathy.
SJ-MX3991 DO-264 DO264 is a potent, selective, and in vivo active ABHD12 inhibitor with an IC50 value of 11 nM. DO264 augments inflammatory cytokine production from human THP-1 macrophage cells.