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Chloride Channel

Chloride Channel相关产品(12)
货号 产品名 中文名称 产品描述
SJ-MX3778 NPPB NPPB is a novel and potent cystic fibrosis transmembrane conductance regulator (CFTR) channel blocker.
SJ-MX1449 Niflumic acid 氟尼酸 Niflumic acid是钙离子激活的氯离子通道阻断剂,可作用于风湿性关节炎。
SJ-MX1656 EACT EACT 是一种选择性强的 TMEM16A 激活剂,直接激活感觉伤害感受器中的 TRPV1 通道,产生瘙痒、急性伤害感受和热敏反应。
SJ-MX2288 Shikonin 紫草素 (Rac)-Shikonin (Shikonin) 具有抗肿瘤活性。(Rac)-Shikonin (Shikonin) 通过诱导坏死死亡来绕过癌症耐药性。
SJ-MX2652 Meticrane 美替克仑 Meticrane 是一种利尿剂。Meticrane 抑制远曲小管中钠离子和氯离子的重吸收。Meticrane 可于研究原发性高血压。
SJ-MX3913 CaCCinh-A01 CaCCinh-A01 is a TMEM16 Blocker. It is a non-selective inhibitor of calcium-activated chloride channels (CaCCs) that blocks ATP-stimulated chloride conductance in human salivary gland, intestinal, and bronchial epithelium (mean IC50= 10 µM).
SJ-MX4367 Adjudin Adjudin is a non-hormonal male contraceptive that exerts its effect by disrupting Sertoli-germ cell adhesion junctions, most notably apical ectoplasmic specialization (apical ES), by targeting testin and actin filament bundles that disrupt the actin-based cytoskeleton in Sertoli cells. Adjudin is a potent blocker of Cl- channels. Moreover, Adjudin is shown to induce apoptosis in cancer cells through a Caspase-3-dependent pathway, and triggers mitochondrial dysfunction in cancer cells.
SJ-MX2210 Talniflumate (BA 7602-06)

Talniflumate (BA 7602-06) 是尼氟酸的前药,通过酯酶转化为尼氟酸,从而在体内发挥其活性。Talniflumate 是具有口服活性的 Ca2+ 激活的 Cl- 通道 (CaCC) 阻滞剂。Talniflumate 可用作远端肠梗阻综合征囊性纤维化小鼠模型的镇痛和抗炎药。

SJ-MA0364 Selamectin 塞拉菌素 Selamectin is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats.
SJ-MN0098 Shikonin 紫草素

Shikonin是一种天然存在的萘醌衍生物,是中草药紫草的主要成分,具有抗炎和抗肿瘤特性。Shikonin 是一种有效的 TMEM16A 氯化物通道 (chloride channel) 抑制剂,IC50 为 6.5 μM。Shikonin 是一种特异的丙酮酸激酶 M2 (PKM2) 抑制剂,还可以抑制 TNF-α 和 NF-κB途径。Shikonin 通过抑制糖酵解降低外泌体 (exosome) 的分泌。Shikonin 抑制 AIM2炎性体活化。

SJ-MN1233 Atractyloside potassium salt 苍术苷钾盐 Atractyloside potassium salt 是一种有毒的二萜苷类化合物,可以从苍术果实中分离出得到。Atractyloside potassium salt 是高效、特异性的线粒体 ADP/ATP 转运 (ADP/ATP transport) 抑制剂。Atractyloside potassium salt 能抑制大鼠心脏线粒体膜的氯离子通道。
SJ-MX2793 Flufenamic acid 氟芬那酸

Flufenamic acid (CI-440;CN-27554)是NSAIDs(非甾体抗炎药)类的抗炎药。它能抑制环加氧酶(COX),激活AMPK,还能调节离子通道,阻滞氯离子通道 (chloride channel) 和 L-型钙离子通道 (L-type Ca2+ channel),调节非选择性阳离子通道(NSC),激活K+通道。Flufenamic acid 与TEAD2 YBD 的中央囊袋结合,抑制 TEAD 功能和 TEAD-YAP 依赖性过程,如细胞迁移和增殖。