BAY-293 抑制 HeLa 细胞中 RAS 的激活,IC5 值在亚微摩尔范围内[1]。BAY-293在孵育6分钟后可有效抑制K-562细胞中的pERK水平,而不影响ERK的总蛋白水平[1]。
参考文献
[1]. Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1interaction. Proc Natl Acad Sci U S A. 219 Feb 12;116(7):2551-256.
[1]. Hillig RC, et al. Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1interaction. Proc Natl Acad Sci U S A. 219 Feb 12;116(7):2551-256.